1908 – Brain morphology of subjects with schizophrenia spectrum disorder with and without antipsychotic medication - the northern finland 1966 birth cohort study

2013 ◽  
Vol 28 ◽  
pp. 1
Author(s):  
J. Moilanen ◽  
S. Huhtaniska ◽  
M. Haapea ◽  
E. Jääskeläinen ◽  
J. Veijola ◽  
...  
2011 ◽  
Vol 28 (1) ◽  
pp. 53-58 ◽  
Author(s):  
J. Moilanen ◽  
M. Haapea ◽  
J. Miettunen ◽  
E. Jääskeläinen ◽  
J. Veijola ◽  
...  

AbstractObjectiveTo estimate the prevalence of non-medicated subjects having schizophrenia spectrum disorder and to study how they differ from medicated subjects in terms of sociodemographic and illness-related variables. We also aim to find the predictors for successful antipsychotic withdrawal.MethodsData of 70 subjects with schizophrenic psychoses (mean duration of illness 10.4 years) from the Northern Finland 1966 Birth Cohort were gathered by interview at the age of 34 and from hospital records. The stability of remission was assessed by comparing hospitalization rates between non-medicated and medicated subjects over an 8.7-year additional follow-up period.ResultsTwenty-four (34%) subjects were currently not receiving medication. They were more often males, less often on a disability pension, more often in remission, and had better clinical outcomes. Relapses during the follow-up were equally frequent between non-medicated and medicated subjects (47% vs. 56%). Not having been hospitalised during previous 5 years before the interview predicted long-term successful antipsychotic withdrawal without relapse.ConclusionsDespite a lack of precise predictors, there might be subgroup of schizophrenia spectrum subjects who do not need permanent antipsychotic medication, and a fewer previous psychiatric treatments may indicate such a subgroup.


2021 ◽  
pp. 1-6
Author(s):  
Ida Ringbom ◽  
Jaana Suvisaari ◽  
Antti Kääriälä ◽  
Andre Sourander ◽  
Mika Gissler ◽  
...  

Background Long-term ‘not in education, employment or training’ (NEET) status is an important indicator of youth marginalisation. Aims To carry out a comprehensive overview of the associations between different psychiatric illnesses and long-term NEET status. Method We used the register-based 1987 Finnish Birth Cohort study, which includes all live births in Finland during that year. The analyses comprised 55 273 individuals after exclusions for intellectual disability, death or emigration. We predicted that psychiatric disorders, diagnosed by specialist services between 1998 and 2007 when the cohort were 10–20 years of age, would be associated with subsequent long-term NEET (defined as NEET for at least 5 years between 2008 and 2015, when they were 20–28 years of age). Results In total, 1438 individuals (2.6%) were long-term NEET during follow-up and the associations between long-term NEET and the 11 diagnostic categories we studied were statistically significant (P < 0.001). In multivariate models we included sociodemographic characteristics and upper secondary education as covariates, and the highest effect sizes, measured by odds ratios (OR) with 95% confidence intervals (CI), were found for psychosis (OR = 12.0, 95% CI 9.5–15.2) and autism spectrum disorder (OR = 17.3, 95% CI 11.5–26.0). If individuals had not successfully completed this education, 70.6% of those with autism spectrum disorder and 48.4% of those with psychosis were later long-term NEET. Conclusions Adolescents who receive treatment for psychiatric disorders, particularly autism spectrum disorder or psychosis, need support to access education and employment. This could help to prevent marginalisation in early adulthood.


2017 ◽  
Vol 48 (4) ◽  
pp. 529-536 ◽  
Author(s):  
F. Waters ◽  
J. D. Blom ◽  
R. Jardri ◽  
K. Hugdahl ◽  
I. E. C. Sommer

Auditory hallucinations (AH) are often considered a sign of a psychotic disorder. This is promoted by the DSM-5 category of Other Specified Schizophrenia Spectrum And Other Psychotic Disorder (OSSSOPD), the diagnostic criteria for which are fulfilled with the sole presence of persistent AH, in the absence of any other psychotic symptoms. And yet, persistent AH are not synonymous with having a psychotic disorder, and should therefore not be uncritically treated as such. Many people who seek treatment for persistent AH have no other psychotic symptoms, have preserved reality-testing capacities, and will never develop a schizophrenia spectrum disorder. Instead, hallucinations may be the result of many different causes, including borderline personality disorder, post-traumatic stress disorder (PTSD), hearing loss, sleep disorders or brain lesions, and they may even occur outside the context of any demonstrable pathology. In such cases, the usage of the DSM-5 diagnosis of OSSSOPD would be incorrect, and it may prompt unwarranted treatment with antipsychotic medication. We therefore argue that a DSM-5 diagnosis of Schizophrenia Spectrum Disorder (or any other type of psychotic disorder) characterized by AH should require at least one more symptom listed under the A-criterion (i.e. delusions, disorganized speech, disorganized or catatonic behavior or negative symptoms). Adhering to these more stringent criteria may help to distinguish between individuals with persistent AH which are part of a psychotic disorder, for whom antipsychotic medication may be helpful, and individuals with AH in the absence of such a disorder who may benefit from other approaches (e.g. different pharmacological interventions, improving coping style, trauma-related therapy).


2016 ◽  
Vol 173 (1-2) ◽  
pp. 62-68 ◽  
Author(s):  
Nina Rautio ◽  
Juha Käkelä ◽  
Tanja Nordström ◽  
Jouko Miettunen ◽  
Sirkka Keinänen-Kiukaanniemi ◽  
...  

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