Asymmetric synthesis of (2R, 1′S, 2′R, 3′S) — 2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG 13), the first selective antagonist of metabotropic glutamate receptors coupled to phospholipase D

Selective Antagonist ◽

(2R,1‘S,2‘R,3‘S)-2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors: Asymmetric Synthesis and Preliminary Biological Properties

Journal of Medicinal Chemistry ◽

10.1021/jm990128v ◽

1999 ◽

Vol 42 (14) ◽

pp. 2716-2720 ◽

Cited By ~ 22

Author(s):

Roberto Pellicciari ◽

Maura Marinozzi ◽

Gabriele Costantino ◽

Benedetto Natalini ◽

Flavio Moroni ◽

...

Keyword(s):

Asymmetric Synthesis ◽

Glutamate Receptors ◽

Phospholipase D ◽

Biological Properties ◽

Competitive Antagonist ◽

Metabotropic glutamate receptors coupled to phospholipase D

Neuropharmacology ◽

10.1016/0028-3908(96)84738-1 ◽

1996 ◽

Vol 35 (6) ◽

pp. A23

Author(s):

D.E. Pellegrini-Giampietro ◽

S. Albani ◽

R. Pellicciari ◽

F. Moroni

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Group I Metabotropic Glutamate Receptors Mediate Phospholipase D Stimulation in Rat Cultured Astrocytes

Journal of Neurochemistry ◽

10.1046/j.1471-4159.1999.721441.x ◽

2001 ◽

Vol 72 (4) ◽

pp. 1441-1447 ◽

Cited By ~ 33

Author(s):

Joan-Marc Servitja ◽

Roser Masgrau ◽

Elisabet Sarri ◽

Fernando Picatoste

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Metabotropic Glutamate ◽

Group I ◽

Cultured Astrocytes

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic Acid: A Potent and Selective Antagonist for Metabotropic Glutamate Receptors Negatively Linked to Adenylate Cyclase

Journal of Medicinal Chemistry ◽

10.1021/jm9508144 ◽

1996 ◽

Vol 39 (4) ◽

pp. 814-816 ◽

Cited By ~ 45

Author(s):

Camille G. Wermuth ◽

André Mann ◽

Angèle Schoenfelder ◽

Rebecca A. Wright ◽

Bryan G. Johnson ◽

...

Keyword(s):

Adenylate Cyclase ◽

Glutamate Receptors ◽

Dioic Acid ◽

Selective Antagonist ◽

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

Neuropharmacology ◽

10.1016/s0028-3908(97)00191-3 ◽

1998 ◽

Vol 37 (1) ◽

pp. 1-12 ◽

Cited By ~ 270

Author(s):

A.E Kingston ◽

P.L Ornstein ◽

R.A Wright ◽

B.G Johnson ◽

N.G Mayne ◽

...

Keyword(s):

Glutamate Receptors ◽

Selective Antagonist ◽

Metabotropic Glutamate ◽

Group Ii

Modulation of baroreceptor afferent terminal excitability and reflex responses by phospholipase D‐coupled metabotropic glutamate receptors

The FASEB Journal ◽

10.1096/fasebj.26.1_supplement.892.8 ◽

2012 ◽

Vol 26 (S1) ◽

Author(s):

Julian Francis Paton ◽

Robert W Banks ◽

Guy S Bewick

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Reflex Responses ◽

Metabotropic Glutamate ◽

Afferent Terminal ◽

Terminal Excitability

ChemInform Abstract: Stereoselective Synthesis of (S)-(+)-αM4CPG (XIV), a Selective Antagonist of Metabotropic Glutamate Receptors.

ChemInform ◽

10.1002/chin.199641194 ◽

2010 ◽

Vol 27 (41) ◽

pp. no-no

Author(s):

D. MA ◽

H. TIAN

Keyword(s):

Glutamate Receptors ◽

Stereoselective Synthesis ◽

Selective Antagonist ◽

ChemInform Abstract: Asymmetric Synthesis of Enantiomerically Pure (2S,1′S,2′S,3′R)- Phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors.

ChemInform ◽

10.1002/chin.199703252 ◽

2010 ◽

Vol 28 (3) ◽

pp. no-no

Author(s):

M. MARINOZZI ◽

B. NATALINI ◽

G. COSTANTINO ◽

P. TIJSKENS ◽

C. THOMSEN ◽

...

Keyword(s):

Asymmetric Synthesis ◽

Glutamate Receptors ◽

Enantiomerically Pure ◽

Metabotropic Glutamate ◽

Selective Ligand ◽

Group Ii

Asymmetric synthesis of enantiomerically pure (2S,1′S,2′S,3′R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(96)00407-6 ◽

1996 ◽

Vol 6 (18) ◽

pp. 2243-2246 ◽

Cited By ~ 8

Author(s):

Maura Marinozzi ◽

Benedetto Natalini ◽

Gabriele Costantino ◽

Pierre Tijskens ◽

Christian Thomsen ◽

...

Keyword(s):

Asymmetric Synthesis ◽

Glutamate Receptors ◽

Enantiomerically Pure ◽

Metabotropic Glutamate ◽

Selective Ligand ◽

Group Ii

Dopamine-Induced Plasticity, Phospholipase D (PLD) Activity and Cocaine-Cue Behavior Depend on PLD-Linked Metabotropic Glutamate Receptors in Amygdala

PLoS ONE ◽

10.1371/journal.pone.0025639 ◽

2011 ◽

Vol 6 (9) ◽

pp. e25639 ◽

Cited By ~ 15

Author(s):

Balaji Krishnan ◽

Kathy M. Genzer ◽

Sebastian W. Pollandt ◽

Jie Liu ◽

Joel P. Gallagher ◽

...

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽