(2R,1‘S,2‘R,3‘S)-2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors:  Asymmetric Synthesis and Preliminary Biological Properties

Biological Properties ◽

Competitive Antagonist ◽

Asymmetric synthesis of (2R, 1′S, 2′R, 3′S) — 2-(2′-carboxy-3′-phenylcyclopropyl) glycine (PCCG 13), the first selective antagonist of metabotropic glutamate receptors coupled to phospholipase D

European Journal of Pharmaceutical Sciences ◽

10.1016/s0928-0987(98)91336-7 ◽

1998 ◽

Vol 6 ◽

pp. S34

Keyword(s):

Asymmetric Synthesis ◽

Glutamate Receptors ◽

Phospholipase D ◽

Selective Antagonist ◽

Metabotropic glutamate receptors coupled to phospholipase D

Neuropharmacology ◽

10.1016/0028-3908(96)84738-1 ◽

1996 ◽

Vol 35 (6) ◽

pp. A23

Author(s):

D.E. Pellegrini-Giampietro ◽

S. Albani ◽

R. Pellicciari ◽

F. Moroni

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Group I Metabotropic Glutamate Receptors Mediate Phospholipase D Stimulation in Rat Cultured Astrocytes

Journal of Neurochemistry ◽

10.1046/j.1471-4159.1999.721441.x ◽

2001 ◽

Vol 72 (4) ◽

pp. 1441-1447 ◽

Cited By ~ 33

Author(s):

Joan-Marc Servitja ◽

Roser Masgrau ◽

Elisabet Sarri ◽

Fernando Picatoste

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Metabotropic Glutamate ◽

Group I ◽

Cultured Astrocytes

Modulation of baroreceptor afferent terminal excitability and reflex responses by phospholipase D‐coupled metabotropic glutamate receptors

The FASEB Journal ◽

10.1096/fasebj.26.1_supplement.892.8 ◽

2012 ◽

Vol 26 (S1) ◽

Author(s):

Julian Francis Paton ◽

Robert W Banks ◽

Guy S Bewick

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Reflex Responses ◽

Metabotropic Glutamate ◽

Afferent Terminal ◽

Terminal Excitability

ChemInform Abstract: Asymmetric Synthesis of Enantiomerically Pure (2S,1′S,2′S,3′R)- Phenylcarboxycyclopropylglycine (PCCG-4): A Potent and Selective Ligand at Group II Metabotropic Glutamate Receptors.

ChemInform ◽

10.1002/chin.199703252 ◽

2010 ◽

Vol 28 (3) ◽

pp. no-no

Author(s):

M. MARINOZZI ◽

B. NATALINI ◽

G. COSTANTINO ◽

P. TIJSKENS ◽

C. THOMSEN ◽

...

Keyword(s):

Asymmetric Synthesis ◽

Glutamate Receptors ◽

Enantiomerically Pure ◽

Metabotropic Glutamate ◽

Selective Ligand ◽

Group Ii

Asymmetric synthesis of enantiomerically pure (2S,1′S,2′S,3′R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(96)00407-6 ◽

1996 ◽

Vol 6 (18) ◽

pp. 2243-2246 ◽

Cited By ~ 8

Author(s):

Maura Marinozzi ◽

Benedetto Natalini ◽

Gabriele Costantino ◽

Pierre Tijskens ◽

Christian Thomsen ◽

...

Keyword(s):

Asymmetric Synthesis ◽

Glutamate Receptors ◽

Enantiomerically Pure ◽

Metabotropic Glutamate ◽

Selective Ligand ◽

Group Ii

Dopamine-Induced Plasticity, Phospholipase D (PLD) Activity and Cocaine-Cue Behavior Depend on PLD-Linked Metabotropic Glutamate Receptors in Amygdala

PLoS ONE ◽

10.1371/journal.pone.0025639 ◽

2011 ◽

Vol 6 (9) ◽

pp. e25639 ◽

Cited By ~ 15

Author(s):

Balaji Krishnan ◽

Kathy M. Genzer ◽

Sebastian W. Pollandt ◽

Jie Liu ◽

Joel P. Gallagher ◽

...

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Ontogenetic and Pharmacological Studies on Metabotropic Glutamate Receptors Coupled to Phospholipase D Activation

Neuropharmacology ◽

10.1016/s0028-3908(97)00024-5 ◽

1997 ◽

Vol 36 (3) ◽

pp. 305-311 ◽

Cited By ~ 31

Author(s):

J KLEIN ◽

M IOVINO ◽

M VAKIL ◽

H SHINOZAKI ◽

K LÖFFELHOLZ

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Metabotropic Glutamate ◽

Pharmacological Studies

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1996.tb15503.x ◽

1996 ◽

Vol 118 (4) ◽

pp. 1035-1043 ◽

Cited By ~ 55

Author(s):

Domenico E. Pellegrini-Giampietro ◽

Serenella Albani Torregrossa ◽

Flavio Moroni

Keyword(s):

Glutamate Receptors ◽

Phospholipase D ◽

Rat Hippocampus ◽

Pharmacological Characterization ◽

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway

Neuropharmacology ◽

10.1016/s0028-3908(02)00361-1 ◽

2003 ◽

Vol 44 (2) ◽

pp. 171-180 ◽

Cited By ~ 13

Author(s):

J Servitja

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Glutamate Receptors ◽

Phospholipase D ◽

Metabotropic Glutamate ◽

Kinase C