Prognostic effect of amenorrhoea and elevated serum gonadotropin levels induced by adjuvant chemotherapy in premenopausal node-positive breast cancer patients

2000 ◽  
Vol 36 (1) ◽  
pp. 43-48 ◽  
Author(s):  
P Poikonen ◽  
T Saarto ◽  
I Elomaa ◽  
H Joensuu ◽  
C Blomqvist
1997 ◽  
Vol 43 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Tanja Fehm ◽  
Peter Maimonis ◽  
Stephen Weitz ◽  
Yosh Teramoto ◽  
Alexander Katalinic ◽  
...  

The Breast ◽  
2003 ◽  
Vol 12 ◽  
pp. S39
Author(s):  
E. Del Barco ◽  
M.I. Ruiz ◽  
C.A. Rodriguez ◽  
A. Gomez ◽  
P. Sanchez ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Hamid Reza Mirzaei ◽  
Fatemeh Nasrollahi ◽  
Ladan Mohammadi Yeganeh ◽  
Sepideh Jafari Naeini ◽  
Pegah Bikdeli ◽  
...  

Background. Adding taxanes to anthracycline-based adjuvant chemotherapy has shown significant improvement in node-positive breast cancer patients but the optimal dose schedule has still remained undetermined. Objectives. The feasibility of dose-dense epirubicin in combination with cyclophosphamide (EC) followed by weekly paclitaxel as adjuvant chemotherapy in node-positive breast cancer patients was investigated. Methods. All patients were treated with epirubicin (100 mg/m2) and cyclophosphamide (600 mg/m2) every two weeks for four cycles with daily Pegfilgrastim (G-CSF) that was administered 3–10 days after each cycle of epirubicin and cyclophosphamide infusion which followed by (80 mg/m2) paclitaxel for twelve consecutive weeks. Results. Sixty consecutive patients were analyzed, of whom 57 patients (95%) completed the regimen and no case of toxicity-related death was observed. Grade 3/4 hematologic toxicity was uncommon and the most common grade 3/4 nonhematological adverse event was neuropathy disorders. Conclusions. Dose-dense epirubicin and cyclophosphamide followed by weekly paclitaxel with G-CSF support is a well-tolerated and feasible regimen in node-positive breast cancer patients without serious complications.


2010 ◽  
Vol 16 (15) ◽  
pp. 3988-3997 ◽  
Author(s):  
Charles Dumontet ◽  
Maryla Krajewska ◽  
Isabelle Treilleux ◽  
John R. Mackey ◽  
Miguel Martin ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document