Synthesis, biological activity and comparative analysis of DNA binding affinities and human DNA topoisomerase I inhibitory activities of novel 12-alkoxy-benzo[c]phenanthridinium salts

2001 ◽  
Vol 11 (19) ◽  
pp. 2643-2646 ◽  
Author(s):  
Michael A Lynch ◽  
Olivier Duval ◽  
Alyona Sukhanova ◽  
Jerome Devy ◽  
Simon P MacKay ◽  
...  
Keyword(s):  
Biological Activity ◽  
Comparative Analysis ◽  
Dna Binding ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Binding Affinities ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Inhibitory Activities ◽  
Human Dna Topoisomerase I

DNA binding induces conformational transition within human DNA topoisomerase I in solution

Biopolymers ◽  
2002 ◽  
Vol 67 (6) ◽  
pp. 369-375 ◽  
Author(s):  
Vladimir Oleinikov ◽  
Alyona Sukhanova ◽  
Konstantin Mochalov ◽  
Olga Ustinova ◽  
Irina Kudelina ◽  
...  
Keyword(s):  
Dna Binding ◽  
Topoisomerase I ◽  
Conformational Transition ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

2003 ◽  
Vol 66 (10) ◽  
pp. 1981-1991 ◽  
Author(s):  
Chun-Yuan Ting ◽  
Chia-Tse Hsu ◽  
Hsiang-Ting Hsu ◽  
Jin-Shan Su ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas

DNA Repair ◽  
2007 ◽  
Vol 6 (12) ◽  
pp. 1757-1763 ◽  
Author(s):  
Christian Mielke ◽  
Faiza M. Kalfalah ◽  
Morten O. Christensen ◽  
Fritz Boege
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I
Sign in / Sign up

Export Citation Format

Share Document