scholarly journals Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase

Structure ◽  
1998 ◽  
Vol 6 (6) ◽  
pp. 735-746 ◽  
Author(s):  
Joseph N Varghese ◽  
Paul W Smith ◽  
Steven L Sollis ◽  
Tony J Blick ◽  
Anjali Sahasrabudhe ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Drug Design ◽  
Structural Basis ◽  
Influenza Virus Neuraminidase

Binding Mechanism of H5N1 Influenza Virus Neuraminidase with Ligands and its Implication for Drug Design

2009 ◽  
Vol 5 (3) ◽  
pp. 242-249 ◽  
Author(s):  
Ke Gong ◽  
Lin Li ◽  
Jing-Fang Wang ◽  
Feng Cheng ◽  
Dong-Qing Wei ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Drug Design ◽  
Binding Mechanism ◽  
H5n1 Influenza Virus ◽  
H5n1 Influenza ◽  
Influenza Virus Neuraminidase

scholarly journals Small Molecule Inhibitors of Influenza Virus Entry

2021 ◽  
Vol 14 (6) ◽  
pp. 587
Author(s):  
Zhaoyu Chen ◽  
Qinghua Cui ◽  
Michael Caffrey ◽  
Lijun Rong ◽  
Ruikun Du
Keyword(s):  
Influenza Virus ◽  
Membrane Fusion ◽  
Small Molecule ◽  
Drug Target ◽  
Small Molecule Inhibitors ◽  
Virus Entry ◽  
Critical Role ◽  
Structural Basis ◽  
Future Directions ◽  
The Past

Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA inhibitors mainly targeting its fusion machinery. In this review, we summarize the advances in HA-targeted development of small molecule inhibitors. Moreover, we discuss the structural basis and mode of action of these inhibitors, and speculate upon future directions toward more potent inhibitors of membrane fusion and potential anti-influenza drugs.

scholarly journals Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

2009 ◽  
Vol 284 (38) ◽  
pp. 25697-25703 ◽  
Author(s):  
Iain D. Kerr ◽  
Ji H. Lee ◽  
Christopher J. Farady ◽  
Rachael Marion ◽  
Mathias Rickert ◽  
...  
Keyword(s):  
Drug Design ◽  
Structural Basis ◽  
Antiparasitic Agents

Docking and 3D QSAR study of thiourea analogs as potent inhibitors of influenza virus neuraminidase

2010 ◽  
Vol 16 (12) ◽  
pp. 1809-1818 ◽  
Author(s):  
Jiaying Sun ◽  
Shaoxi Cai ◽  
Hu Mei ◽  
Jian Li ◽  
Ning Yan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
3D Qsar ◽  
Qsar Study ◽  
Influenza Virus Neuraminidase

Influenza Virus Neuraminidase Inhibitory Activity of Phlorotannins from the Edible Brown AlgaEcklonia cava

2011 ◽  
Vol 59 (12) ◽  
pp. 6467-6473 ◽  
Author(s):  
Young Bae Ryu ◽  
Hyung Jae Jeong ◽  
So Young Yoon ◽  
Ji-Young Park ◽  
Young Min Kim ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inhibitory Activity ◽  
Influenza Virus Neuraminidase

Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir

2015 ◽  
Vol 210 ◽  
pp. 126-132 ◽  
Author(s):  
S.-H. Sheldon Tai ◽  
Olga Agafitei ◽  
Zhizeng Gao ◽  
Richard Liggins ◽  
Martin Petric ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Influenza Virus ◽  
Neuraminidase Inhibitors ◽  
Influenza Virus Neuraminidase

scholarly journals Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Yan Wu ◽  
Guangrong Qin ◽  
Feng Gao ◽  
Yue Liu ◽  
Christopher J. Vavricka ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inhibitor Binding ◽  
Influenza Virus Neuraminidase
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