Adenoid Cystic Carcinoma of the Major Salivary Glands Treated With Surgery and Radiation

AbstractObjective:To verify the prevalence of cervical lymph node metastasis in adenoid cystic carcinoma of major salivary glands, and to establish recommendations for elective neck treatment.Methods:A search was conducted of the US National Library of Medicine database. Appropriate articles were selected from the abstracts, and the original publications were obtained to extract data.Results:Among 483 cases of major salivary gland adenoid cystic carcinoma, a total of 90 (18.6 per cent) had cervical metastasis. The prevalence of positive nodes from adenoid cystic carcinoma was 14.5 per cent for parotid gland, 22.5 per cent for submandibular gland and 24.7 per cent for sublingual gland. Cervical lymph node metastasis occurred more frequently in patients with primary tumour stage T3–4 adenoid cystic carcinoma, and was usually located in levels II and III in the neck.Conclusion:Adenoid cystic carcinoma of the major salivary glands is associated with a significant prevalence of cervical node metastasis, and elective neck treatment is indicated for T3 and T4 primary tumours, as well as tumours with other histological risk factors.

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Adenoid Cystic Carcinoma of the Major Salivary Glands Treated with Surgery and Radiation

The Laryngoscope ◽

10.1097/01.mlg.0000165381.64157.ad ◽

2005 ◽

Vol 115 (7) ◽

pp. 1278-1282 ◽

Cited By ~ 62

Author(s):

Theresa A. Gurney ◽

David W. Eisele ◽

Vivian Weinberg ◽

Ed Shin ◽

Nancy Lee

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Adenoid Cystic ◽

Major Salivary Glands

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Large German Multicenter Experience on the Treatment Outcome of 207 Patients With Adenoid Cystic Carcinoma of the Major Salivary Glands

Frontiers in Oncology ◽

10.3389/fonc.2020.593379 ◽

2020 ◽

Vol 10 ◽

Author(s):

Sati Akbaba ◽

Tilman Bostel ◽

Kristin Lang ◽

Suzan Bahadir ◽

Djoeri Lipman ◽

...

Keyword(s):

Treatment Outcome ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Adenoid Cystic ◽

Major Salivary Glands

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Molecular Differences in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Major Salivary Glands

The Laryngoscope ◽

10.1097/00005537-200108000-00011 ◽

2001 ◽

Vol 111 (8) ◽

pp. 1373-1378 ◽

Cited By ~ 50

Author(s):

Mark D. Gibbons ◽

Upender Manne ◽

William R. Carroll ◽

Glenn E. Peters ◽

Heidi L. Weiss ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Mucoepidermoid Carcinoma ◽

Adenoid Cystic ◽

Major Salivary Glands

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Cervical lymph node metastasis in adenoid cystic carcinoma of the sinonasal tract, nasopharynx, lacrimal glands and external auditory canal: a collective international review

The Journal of Laryngology & Otology ◽

10.1017/s0022215116009373 ◽

2016 ◽

Vol 130 (12) ◽

pp. 1093-1097 ◽

Cited By ~ 15

Author(s):

Keyword(s):

Lymph Node ◽

Adenoid Cystic Carcinoma ◽

Head And Neck ◽

Salivary Glands ◽

External Auditory Canal ◽

Sinonasal Tract ◽

Lacrimal Glands ◽

Adenoid Cystic ◽

Major Salivary Glands ◽

Regional Lymph Node Dissection

AbstractObjective:To review reports of adenoid cystic carcinomas arising in the head and neck area outside of the major salivary glands, in order to enhance the care of patients with these unusual neoplasms.Methods:An international team of head and neck surgeons, pathologists, oncologists and radiation oncologists was assembled to explore the published experience and their own working experience of the diagnosis and treatment of adenoid cystic carcinomas arising in the vicinity of the sinonasal tract, nasopharynx, lacrimal glands and external auditory canal.Results:The behaviour of adenoid cystic carcinoma arising in head and neck sites exclusive of the major salivary glands parallels that of tumours with a similar histology arising in the major salivary glands – these are relentless, progressive tumours, associated with high rates of mortality. Of 774 patients reviewed, at least 41 (5.3 per cent) developed documented regional node metastases.Conclusion:The relatively low overall incidence of nodal metastases in adenoid cystic carcinomas arising in the head and neck region outside of the major salivary glands suggests that routine elective regional lymph node dissection might not be indicated in most patients with these tumours.

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