Effects of growth hormone on cardiac function in murine model of dilated cardiomyopathy due to disruption of muscle lim protein gene

1998 ◽  
Vol 4 (3) ◽  
pp. 110
Author(s):  
Minoru Hongo ◽  
Morie Sekiguchi ◽  
Kenneth R. Chien ◽  
John Ross
Keyword(s):  
Growth Hormone ◽  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Murine Model ◽  
Protein Gene ◽  
Lim Protein ◽  
Muscle Lim Protein

Mutations in the muscle LIM protein and α-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis

2003 ◽  
Vol 80 (1-2) ◽  
pp. 207-215 ◽  
Author(s):  
Bhagyalaxmi Mohapatra ◽  
Shinawe Jimenez ◽  
Jiuann Huey Lin ◽  
Karla R Bowles ◽  
Karen J Coveler ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Endocardial Fibroelastosis ◽  
Lim Protein ◽  
Muscle Lim Protein

scholarly journals The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function

2008 ◽  
Vol 211 (1) ◽  
pp. 15-23 ◽  
Author(s):  
A. Mery ◽  
O. Taghli-Lamallem ◽  
K. A. Clark ◽  
M. C. Beckerle ◽  
X. Wu ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Lim Protein ◽  
Muscle Lim Protein

scholarly journals Mutations in the Human Muscle LIM Protein Gene in Families With Hypertrophic Cardiomyopathy

Circulation ◽  
2003 ◽  
Vol 107 (10) ◽  
pp. 1390-1395 ◽  
Author(s):  
Christian Geier ◽  
Andreas Perrot ◽  
Cemil Özcelik ◽  
Priska Binner ◽  
Damian Counsell ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Protein Gene ◽  
Human Muscle ◽  
Lim Protein ◽  
Muscle Lim Protein

scholarly journals Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy

2018 ◽  
Vol 273 ◽  
pp. 168-176 ◽  
Author(s):  
Jiayang Li ◽  
Kenneth S. Gresham ◽  
Ranganath Mamidi ◽  
Chang Yoon Doh ◽  
Xiaoping Wan ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Murine Model ◽  
Genetic Enhancement

Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics

2002 ◽  
Vol 282 (2) ◽  
pp. H680-H687 ◽  
Author(s):  
Jeffrey H. Omens ◽  
Taras P. Usyk ◽  
Zuangjie Li ◽  
Andrew D. McCulloch
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Three Dimensional ◽  
Clinical Signs ◽  
Targeted Disruption ◽  
Lim Protein ◽  
Ventricular Mechanics ◽  
Muscle Lim Protein ◽  
Important Pathway ◽  
Knockout Model

Accumulating evidence indicates that cytoskeletal defects may be an important pathway for dilated cardiomyopathy and eventual heart failure. Targeted disruption of muscle LIM protein (MLP) has previously been shown to result in dilated cardiomyopathy with many of the clinical signs of heart failure, although the effects of MLP disruption on passive ventricular mechanics and myocyte architecture are not known. We used the MLP knockout model to examine changes in passive ventricular mechanics and laminar myofiber sheet architecture. Pressure-volume and pressure-strain relations were altered in MLP knockout mice, in general suggesting a less compliant tissue in the dilated hearts. Transmural laminar myocyte structure was also altered in this mouse model, especially near the epicardium. A mathematical model of the heart showed a likely increase in passive tissue stiffness in the MLP-deficient (−/−) heart. These results suggest that the disruption of the cytoskeletal protein MLP results in less compliant passive tissue and concomitant structural alterations in the three-dimensional myocyte architecture that may in part explain the ventricular dysfunction in the dilated heart.

scholarly journals Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure

2016 ◽  
Vol 594 (12) ◽  
pp. 3287-3305 ◽  
Author(s):  
Anju Paudyal ◽  
Sukriti Dewan ◽  
Cindy Ikie ◽  
Benjamin J Whalley ◽  
Pieter P. de Tombe ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Heme Oxygenase ◽  
Nuclear Accumulation ◽  
Heme Oxygenase 1 ◽  
Lim Protein ◽  
Muscle Lim Protein

EsMlp, a Muscle-LIM Protein Gene, Is Up-regulated during Cold Exposure in the Freeze-Avoiding Larvae of Epiblema scudderiana

Cryobiology ◽  
2001 ◽  
Vol 43 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Tolga Bilgen ◽  
Tamara E. English ◽  
Dave C. McMullen ◽  
Kenneth B. Storey
Keyword(s):  
Cold Exposure ◽  
Protein Gene ◽  
Lim Protein ◽  
Epiblema Scudderiana ◽  
Muscle Lim Protein
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