Hepatocellular Carcinoma in Ten Children Under Five Years of Age With Bile Salt Export Pump Deficiency

2008 ◽  
Vol 2008 ◽  
pp. 292-293
Author(s):  
R. Jaffe
Hepatology ◽  
2006 ◽  
Vol 44 (2) ◽  
pp. 478-486 ◽  
Author(s):  
A. S. Knisely ◽  
Sandra S. Strautnieks ◽  
Yvonne Meier ◽  
Bruno Stieger ◽  
Jane A. Byrne ◽  
...  

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Fabio Iannelli ◽  
Agnese Collino ◽  
Shruti Sinha ◽  
Enrico Radaelli ◽  
Paola Nicoli ◽  
...  

2015 ◽  
Vol 66 (4) ◽  
pp. 598-602 ◽  
Author(s):  
Stephen M Lagana ◽  
Marcela Salomao ◽  
Helen E Remotti ◽  
A.S. Knisely ◽  
Roger K Moreira

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Fabio Iannelli ◽  
Agnese Collino ◽  
Shruti Sinha ◽  
Enrico Radaelli ◽  
Paola Nicoli ◽  
...  

Hepatology ◽  
2013 ◽  
Vol 57 (4) ◽  
pp. 1530-1541 ◽  
Author(s):  
Yuan Chen ◽  
Xiulong Song ◽  
Leila Valanejad ◽  
Alexander Vasilenko ◽  
Vijay More ◽  
...  

2015 ◽  
Vol 139 (8) ◽  
pp. 1028-1034 ◽  
Author(s):  
Thuy Nguyen ◽  
Daniel Phillips ◽  
Dhanpat Jain ◽  
Michael Torbenson ◽  
Tsung-Teh Wu ◽  
...  

Context Several immunohistochemical markers are available to establish the diagnosis of hepatocellular carcinoma. Judicious selection is essential to achieve a reliable diagnosis in limited tissue provided by liver biopsy. Objective To compare the efficacy of 5 hepatocellular markers for the diagnosis of hepatocellular carcinoma across various levels of differentiations. Design Immunohistochemistry for hepatocyte paraffin antigen 1 (Hep Par 1), polyclonal carcinoembryonic antigen (CEA), glypican-3, arginase-1, and bile salt export pump transporter was performed in 79 hepatocellular carcinomas, yielding 93 observations (13 well-differentiated [14%], 41 moderately differentiated [44%], and 39 poorly differentiated [42%] tumors). Results Arginase-1 and Hep Par 1 had the highest sensitivity for well-differentiated hepatocellular carcinoma, whereas arginase-1 and glypican-3 had the highest sensitivity for poorly differentiated hepatocellular carcinoma. When staining of more than 50% of the tumor was considered a positive result, arginase-1 remained the most sensitive marker for all differentiations, whereas sensitivity for Hep Par 1 in poorly differentiated hepatocellular carcinoma dropped to 30% and that of glypican-3 in well-differentiated hepatocellular carcinoma was 15%. The addition of Hep Par 1 and/or polyclonal CEA to arginase-1 did not lead to an increase in sensitivity for any differentiation. The combined use of arginase-1 and glypican-3 yielded 100% sensitivity for poorly differentiated hepatocellular carcinoma. Conclusion Arginase-1 was the most sensitive marker in all differentiations of hepatocellular carcinoma. Glypican-3 had high sensitivity for poorly differentiated cases and its combined use with arginase-1 enabled identification of nearly all cases of poorly differentiated hepatocellular carcinoma. Although bile salt export pump transporter has good overall sensitivity, it has a limited role in establishing hepatocellular differentiation when added to a panel of arginase-1 with either glypican-3 or Hep Par 1.


2019 ◽  
Author(s):  
J Remetic ◽  
V Mlitz ◽  
V Kunczer ◽  
H Scharnagl ◽  
T Stojakovic ◽  
...  

2017 ◽  
Vol 1 (1) ◽  
pp. 26
Author(s):  
Ade Kartikasari Sebba ◽  
Baning Rahayujati ◽  
Isa Dharmawidjaja

Pneumonia is one of the deadliest diseases for children under five years-old throughout the world. In Indonesia, pneumonia is the second deadliest disease after diarrhea. In 2015-2016, the Coverage of pneumonia case detection on children under five years-old increased from 22.33% to 36.06% but it had not achieved the detection target (-85%). A program evaluation needs to conduct, consequently. The evaluation aims to observe the implementation of pneumonia investigation program on children under five years-old in Sleman in 2016. The evaluation used a descriptive design performed in June-July 2017. The research subject was the program of Upper Respiratory Infection (ISPA, Infeksi Saluran Pernapasan Akut) implemented in community health centers (puskesmas, pusat kesehatan masyarakat). Twenty respondents as the sample were chosen by using the purposive sampling technique. The surveillance evaluation employed the input, activities, and output. The instruments were structural questionnaires and checklist sheets. The analysis result was presented in forms of tabulation and narration. From the input facet, 100% respondents have not had any special trainings related to pneumonia. 55% respondents have interlocking jobs with the longest service time of three years or more (75%). 70% respondents are able to show ARI Soundtimer. There are only 10% respondents holding the media of communication, information, and education (KIE, Komunikasi, Informasi, dan Edukasi) in forms of flipchart and leaflet; while 100% respondents admit that they have no stamp seal of URI. The proses facet displays that 100% respondents do not arrange any plan. The case investigation is only passive (100%). 80% respondents do socialization of case management and only 15% respondents perform a home visit. 100% respondents have not held trainings for responsible people, alert villages, and private midwives. From the output facet, the scope of case investigation is still low (36.06%).The implementation of pneumonia case investigation program on children under five years-old has been well executed but there are still weaknesses. Hence, public health offices (dinas kesehatan) should improve their human resources by arran ging a training program, equalize the use of breath counting tool and make MoU with all health services to report pneumonia cases. Community health centers are recommended to arrange plans, actively attempt to discover pneumonia cases, and train the responsible people, centers for pre-and postnatal health care (posyandu, pos pelayanan terpadu), or midwives related to the subject of pneumonia.


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