Immunohistochemical evaluation of cell proliferation antigen Ki-67 and apoptosis-related proteins Bcl-2 and caspase-3 in oral granular cell tumor

2003 ◽  
Vol 96 (5) ◽  
pp. 566-572 ◽  
Author(s):  
Evanthia Chrysomali ◽  
Nikolaos G. Nikitakis ◽  
Konstantinos Tosios ◽  
John J. Sauk ◽  
Stavros I. Papanicolaou
Keyword(s):  
Cell Proliferation ◽  
Caspase 3 ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Ki 67 ◽  
Related Proteins

Granular Cell Tumor: Immunohistochemical Assessment of Inhibin-α, Protein Gene Product 9.5, S100 Protein, CD68, and Ki-67 Proliferative Index With Clinical Correlation

2004 ◽  
Vol 128 (7) ◽  
pp. 771-775 ◽  
Author(s):  
Brian H. Le ◽  
Philip J. Boyer ◽  
Jean E. Lewis ◽  
Silloo B. Kapadia
Keyword(s):  
Gene Product ◽  
Granular Cell Tumor ◽  
Protein Gene ◽  
Granular Cell ◽  
Cell Tumor ◽  
Protein Gene Product 9.5 ◽  
Proliferative Index ◽  
Ki 67 ◽  
Protein Gene Product ◽  
Immunohistochemical Assessment

Abstract Context.—Granular cell tumor (GCT) is a rare tumor of nerve sheath origin with a predilection for upper aerodigestive tract, skin, and soft tissue. The neoplastic cells typically express S100 and CD68 (KP-1), the latter due to cytoplasmic lysosome content. However, the histogenesis of this tumor is unknown. Additionally, distinction between benign and malignant GCT is difficult because of histologic similarity and lack of reliable criteria that can predict clinical behavior. Objective.—To perform a comparative, side-by-side immunohistochemical assessment of the traditional immunohistochemical markers for GCTs (S100, CD68), along with the newer markers (inhibin-α, protein gene product 9.5) for these tumors. Design.—To address diagnostic and prognostic issues, we studied 30 specimens of GCT (27 primary and 3 recurrent tumors, 2 of which occurred consecutively in the same patient) for (1) nuclear pleomorphism, prominent nucleoli, necrosis, spindling, high nuclear-cytoplasmic ratio, and mitoses; (2) immunohistochemical expression of inhibin-α, protein gene product 9.5, S100, CD68 (KP-1), and Ki-67 using the avidin-biotin complex method on formalin-fixed, paraffin-embedded sections; and (3) correlation between tumor grade, proliferative fraction, and clinical data. Results.—Twenty-seven of 27 primary GCTs and 1 of 3 recurrent GCTs had typical histologic features, while the 2 consecutive recurrent GCT specimens from the same patient were atypical (moderate nuclear atypia and prominent nucleoli alone). The mean age for primary GCT was 37.3 years (range, 5–67 years), and mean size was 1.89 cm. None of the cases metastasized. All 30 specimens showed diffuse (2+ to 3+) staining for S100, CD68, and inhibin-α, and 3+ staining for protein gene product 9.5; pseudoepitheliomatous hyperplasia was nonreactive. The Ki-67 proliferative index was less than 1% to 20% in typical nonrecurrent cases, 1% in the typical recurrent case, and 1% and 10% in 2 sequential recurrences of the atypical case. Conclusion.—Our study expands the immunophenotype of GCT (S100, CD68, protein gene product 9.5, and inhibin-α) regardless of location and supports a neural origin. Intensity of immunohistochemical staining had no prognostic significance. Although 1 of the 2 recurrent GCTs had atypical features, the Ki-67 proliferative index did not distinguish reliably between typical (nonrecurrent) and atypical or recurrent GCTs. The significance of inhibin expression with regard to cell differentiation and pathogenesis is unclear and warrants further investigation.

scholarly journals Multifocal Abrikossoff's granular cell tumor of the oesophagus: Case report

2008 ◽  
Vol 136 (9-10) ◽  
pp. 533-537 ◽  
Author(s):  
Tomislav Randjelovic ◽  
Zorica Stojsic ◽  
Jasna Gacic ◽  
Darko Babic ◽  
Miodrag Stojiljkovic ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
Pathological Finding ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Ki 67 ◽  
Luminal Narrowing ◽  
Operative Specimen

INTRODUCTION Granular cell tumors, relatively uncommon soft tissue tumors, have been a matter of debate among pathologists regarding histogenesis for a long time. Less common locations are in the aerodigestive tract including the oesophagus. CASE OUTLINE We have recently treated a rare case, a 37-year old male, who was admitted due to dysphagia and a painful swallow with occasional pharyngo-nasal regurgitation followed with a mild loss of weight. Standard clinical examination including X-ray chest, ECG and laboratory tests did not show pathological findings. Barium contrast oesophagography demonstrated multiple ovoid defects in the wall of the oesophagus. CT scan of the chest confirmed luminal narrowing owing to the tumor of the upper oesophagus. Upper endoscopy showed unusual multifocal nodular lesions alongside the oesophageal axis covered by smooth mucosa. A primary biopsy specimen taken from the largest nodules confirmed an unusual pathological finding of the granular cell tumor. Subtotal, transpleural oesophagectomy was performed and reconstruction was derived by long colon segment interposition through the posterior mediastinum. The postoperative course was uneventful. The operative specimen consisted of four ovoid tumors alongside the oesophagus (the greatest diameter 0.5-1.8, average 1.25). All verified tumors histologicaly consisted of a spindle-shaped or polygonal cells containing small and large eosinophilic granules and central nuclei. Most tumor cells showed strongly positive immunohistochemical staining for S-100 protein. These tumor cells were partially positive for p-53 and Ki-67. No lymph node metastases were detected histologically. CONCLUSION Multifocal granular cell tumor of the oesophagus is an unusual finding with low incidence, and rarely caused symptoms. Pathological features and multiplicity of such tumors emphasized malignant predisposition requiring surgical resection of the oesophagus.

scholarly journals Malignant granular cell tumor of the ulnar nerve: A case report of long-term follow-up and literature review

2021 ◽  
Vol 8 (1) ◽  
pp. 27
Author(s):  
Sei Morinaga ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Ulnar Nerve ◽  
Poor Prognosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Ki 67 ◽  
S 100 ◽  
Long Term Follow Up ◽  
Malignant Granular Cell Tumor

Background: The incidence of malignant granular cell tumor, an extremely rare Schwann cell-derived tumor with a poor prognosis, is reported to be approximately 0.2% of malignant soft tissue tumors. We report a case of a malignant granular cell tumor originating from the ulnar nerve.Case presentation: A 71-year-old woman presented with a mass in her right forearm. Magnetic resonance imaging showed a tumor with homogenous intensity of T1 and heterogeneous hyperintensity of T2, continuous with the ulnar nerve. Incisional biopsy revealed a malignant granular cell tumor, and marginal excision of the tumor was performed. Histologically, the tumor size was 9.2 cm and consisted of eosinophilic, granular polygonal to round and spindle-shaped cells, with vesicular and prominent nucleoli, and increased mitosis. Immunohistochemically, the tumor cells were positive for S-100 protein, CD68, H3K27me3, TFE3, and SOX10 and negative for smooth muscle alpha-actin, desmin, cytokeratin AE1/3, epithelial membrane antigen, and synaptophysin. The Ki-67 positivity rate was 12%. These findings were consistent with those of malignant granular cell tumors. In addition, no metastasis or recurrence was observed 15 years after the excision.Conclusion: Surgical resection is the standard treatment option. In our case, the diagnostic criteria for malignant granular cell tumors were histologically met. Patients with malignant granular cell tumors have a poor prognosis. However, no metastasis or recurrence was observed in this case 15 years after the surgery.

Abstract #804: Granular Cell Tumor of the Neurohypophysis

2017 ◽  
Vol 23 ◽  
pp. 163
Author(s):  
Dalitza Alvarez-Valentin ◽  
Milliette Alvarado Santiago ◽  
Loida Gonzalez-Rodriguez ◽  
Margarita Ramirez-Vick ◽  
Juan Perez-Berenguer
Keyword(s):  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

Granular Cell Tumor Simulating Breast Malignancy: A Case Report

2006 ◽  
Vol 55 (2) ◽  
pp. 199 ◽  
Author(s):  
Sung Soo Lee ◽  
Yun Woo Chang ◽  
Duek Lin Choi ◽  
Dong Erk Goo ◽  
Seung Boo Yang ◽  
...  
Keyword(s):  
Case Report ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Breast Malignancy

A Case of Pediatric Laryngeal Granular Cell Tumor

2017 ◽  
Vol 68 (1) ◽  
pp. 32-39
Author(s):  
Maki Inoue ◽  
Noboru Ogahara ◽  
Nobuhiko Oridate
Keyword(s):  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

Granular Cell Tumor of the Presacral Space

2000 ◽  
Vol 174 (4) ◽  
pp. 1165-1166
Author(s):  
Jae-Joon Chung ◽  
Sun Yang Chung ◽  
Myeong-Jin Kim
Keyword(s):  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Presacral Space

Colonic granular cell tumor identified in an adenomatous polyp

2021 ◽  
Author(s):  
Emanuel Dias ◽  
João Santos-Antunes ◽  
Ana Luísa Santos ◽  
Rosa Coelho ◽  
Daniel Melo ◽  
...  
Keyword(s):  
Adenomatous Polyp ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor
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