scholarly journals Multifocal Abrikossoff's granular cell tumor of the oesophagus: Case report

2008 ◽  
Vol 136 (9-10) ◽  
pp. 533-537 ◽  
Author(s):  
Tomislav Randjelovic ◽  
Zorica Stojsic ◽  
Jasna Gacic ◽  
Darko Babic ◽  
Miodrag Stojiljkovic ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
Pathological Finding ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Ki 67 ◽  
Luminal Narrowing ◽  
Operative Specimen

INTRODUCTION Granular cell tumors, relatively uncommon soft tissue tumors, have been a matter of debate among pathologists regarding histogenesis for a long time. Less common locations are in the aerodigestive tract including the oesophagus. CASE OUTLINE We have recently treated a rare case, a 37-year old male, who was admitted due to dysphagia and a painful swallow with occasional pharyngo-nasal regurgitation followed with a mild loss of weight. Standard clinical examination including X-ray chest, ECG and laboratory tests did not show pathological findings. Barium contrast oesophagography demonstrated multiple ovoid defects in the wall of the oesophagus. CT scan of the chest confirmed luminal narrowing owing to the tumor of the upper oesophagus. Upper endoscopy showed unusual multifocal nodular lesions alongside the oesophageal axis covered by smooth mucosa. A primary biopsy specimen taken from the largest nodules confirmed an unusual pathological finding of the granular cell tumor. Subtotal, transpleural oesophagectomy was performed and reconstruction was derived by long colon segment interposition through the posterior mediastinum. The postoperative course was uneventful. The operative specimen consisted of four ovoid tumors alongside the oesophagus (the greatest diameter 0.5-1.8, average 1.25). All verified tumors histologicaly consisted of a spindle-shaped or polygonal cells containing small and large eosinophilic granules and central nuclei. Most tumor cells showed strongly positive immunohistochemical staining for S-100 protein. These tumor cells were partially positive for p-53 and Ki-67. No lymph node metastases were detected histologically. CONCLUSION Multifocal granular cell tumor of the oesophagus is an unusual finding with low incidence, and rarely caused symptoms. Pathological features and multiplicity of such tumors emphasized malignant predisposition requiring surgical resection of the oesophagus.

scholarly journals Malignant granular cell tumor of the ulnar nerve: A case report of long-term follow-up and literature review

2021 ◽  
Vol 8 (1) ◽  
pp. 27
Author(s):  
Sei Morinaga ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Ulnar Nerve ◽  
Poor Prognosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Ki 67 ◽  
S 100 ◽  
Long Term Follow Up ◽  
Malignant Granular Cell Tumor

Background: The incidence of malignant granular cell tumor, an extremely rare Schwann cell-derived tumor with a poor prognosis, is reported to be approximately 0.2% of malignant soft tissue tumors. We report a case of a malignant granular cell tumor originating from the ulnar nerve.Case presentation: A 71-year-old woman presented with a mass in her right forearm. Magnetic resonance imaging showed a tumor with homogenous intensity of T1 and heterogeneous hyperintensity of T2, continuous with the ulnar nerve. Incisional biopsy revealed a malignant granular cell tumor, and marginal excision of the tumor was performed. Histologically, the tumor size was 9.2 cm and consisted of eosinophilic, granular polygonal to round and spindle-shaped cells, with vesicular and prominent nucleoli, and increased mitosis. Immunohistochemically, the tumor cells were positive for S-100 protein, CD68, H3K27me3, TFE3, and SOX10 and negative for smooth muscle alpha-actin, desmin, cytokeratin AE1/3, epithelial membrane antigen, and synaptophysin. The Ki-67 positivity rate was 12%. These findings were consistent with those of malignant granular cell tumors. In addition, no metastasis or recurrence was observed 15 years after the excision.Conclusion: Surgical resection is the standard treatment option. In our case, the diagnostic criteria for malignant granular cell tumors were histologically met. Patients with malignant granular cell tumors have a poor prognosis. However, no metastasis or recurrence was observed in this case 15 years after the surgery.

scholarly journals Giant Malignant Granular Cell Tumor (GCT) of the Posterior Mediastinum

2013 ◽  
Vol 8 (8) ◽  
pp. 1107-1108 ◽  
Author(s):  
Giuseppe De Luca ◽  
Antonella Luciano ◽  
Giulio Benincasa ◽  
Raffaele Sessa ◽  
Francesco Petteruti
Keyword(s):  
Granular Cell Tumor ◽  
Granular Cell ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor

Malignant granular cell tumor of the posterior mediastinum with dissemination

2012 ◽  
Vol 20 (1) ◽  
pp. 71-73 ◽  
Author(s):  
Masayuki Nakao ◽  
Tomoyuki Hishida ◽  
Genichiro Ishii ◽  
Junji Yoshida ◽  
Mitsuyo Nishimura ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
Granular Cell ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor

Granular Cell Tumor: Immunohistochemical Assessment of Inhibin-α, Protein Gene Product 9.5, S100 Protein, CD68, and Ki-67 Proliferative Index With Clinical Correlation

2004 ◽  
Vol 128 (7) ◽  
pp. 771-775 ◽  
Author(s):  
Brian H. Le ◽  
Philip J. Boyer ◽  
Jean E. Lewis ◽  
Silloo B. Kapadia
Keyword(s):  
Gene Product ◽  
Granular Cell Tumor ◽  
Protein Gene ◽  
Granular Cell ◽  
Cell Tumor ◽  
Protein Gene Product 9.5 ◽  
Proliferative Index ◽  
Ki 67 ◽  
Protein Gene Product ◽  
Immunohistochemical Assessment

Abstract Context.—Granular cell tumor (GCT) is a rare tumor of nerve sheath origin with a predilection for upper aerodigestive tract, skin, and soft tissue. The neoplastic cells typically express S100 and CD68 (KP-1), the latter due to cytoplasmic lysosome content. However, the histogenesis of this tumor is unknown. Additionally, distinction between benign and malignant GCT is difficult because of histologic similarity and lack of reliable criteria that can predict clinical behavior. Objective.—To perform a comparative, side-by-side immunohistochemical assessment of the traditional immunohistochemical markers for GCTs (S100, CD68), along with the newer markers (inhibin-α, protein gene product 9.5) for these tumors. Design.—To address diagnostic and prognostic issues, we studied 30 specimens of GCT (27 primary and 3 recurrent tumors, 2 of which occurred consecutively in the same patient) for (1) nuclear pleomorphism, prominent nucleoli, necrosis, spindling, high nuclear-cytoplasmic ratio, and mitoses; (2) immunohistochemical expression of inhibin-α, protein gene product 9.5, S100, CD68 (KP-1), and Ki-67 using the avidin-biotin complex method on formalin-fixed, paraffin-embedded sections; and (3) correlation between tumor grade, proliferative fraction, and clinical data. Results.—Twenty-seven of 27 primary GCTs and 1 of 3 recurrent GCTs had typical histologic features, while the 2 consecutive recurrent GCT specimens from the same patient were atypical (moderate nuclear atypia and prominent nucleoli alone). The mean age for primary GCT was 37.3 years (range, 5–67 years), and mean size was 1.89 cm. None of the cases metastasized. All 30 specimens showed diffuse (2+ to 3+) staining for S100, CD68, and inhibin-α, and 3+ staining for protein gene product 9.5; pseudoepitheliomatous hyperplasia was nonreactive. The Ki-67 proliferative index was less than 1% to 20% in typical nonrecurrent cases, 1% in the typical recurrent case, and 1% and 10% in 2 sequential recurrences of the atypical case. Conclusion.—Our study expands the immunophenotype of GCT (S100, CD68, protein gene product 9.5, and inhibin-α) regardless of location and supports a neural origin. Intensity of immunohistochemical staining had no prognostic significance. Although 1 of the 2 recurrent GCTs had atypical features, the Ki-67 proliferative index did not distinguish reliably between typical (nonrecurrent) and atypical or recurrent GCTs. The significance of inhibin expression with regard to cell differentiation and pathogenesis is unclear and warrants further investigation.

Giant Granular Cell Tumor of the Suprasellar Area; Immunocytochemical and Electron Microscopic Studies

Neurosurgery ◽  
1984 ◽  
Vol 15 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Boleslaw H. Liwnicz ◽  
Boleslaw H. Liwnicz ◽  
Regina G. Liwnicz ◽  
Stephen J. Huff ◽  
Bert H. McBride ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Electron Microscopic ◽  
Periodic Acid Schiff ◽  
Computed Tomographic ◽  
Suprasellar Region ◽  
Microscopic Studies

Abstract We describe a case of a granular cell tumor (GCT) of the suprasellar region with an 11-year history in a 26-year-old woman. The computed tomographic scan showed a midline, contrast-enhancing, noncalcified mass. The biopsy was diagnosed as GCT. The tumor was treated with radiation therapy. At necropsy, a large, homogeneous GCT surrounded by gliosis was found. The tumor cells were filled with granules positive for periodic acid-Schiff, diastase-resistant. The cells did not contain glial fibrillary acidic protein or S-100 protein. Electron microscopy showed tumor cells filled with innumerable lysosomal structures. No intermediate filament was found within the cytoplasm. The tumor cells were not surrounded by a basement membrane. Based on this study and on our review of the literature, the suggestion that GCT has a multicellular origin is upheld.

scholarly journals A rare case of cutaneous granular cell tumour

2021 ◽  
Vol 9 (8) ◽  
pp. 2482
Author(s):  
Rohini Arumugam ◽  
Leena Dennis Joseph ◽  
Vidhya Venkatesan ◽  
C. D. Narayanan
Keyword(s):  
Soft Tissue ◽  
Female Patient ◽  
Rare Case ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Granular Cell Tumour ◽  
Uncertain Etiology

Granular cell tumors are uncommon tumors of uncertain etiology. It accounts for approximately 0.5% of all soft tissue tumors. However, the involvement of skin is rare. Only few cases of cutaneous granular cell tumor is reported till date. Here, we present a case of cutaneous granular cell tumor in a 48 years female patient.

scholarly journals Granular Cell Tumor Presenting as a Tracheal Mass in a 17-year-old Female

2008 ◽  
Vol 23 (1) ◽  
pp. 39-40
Author(s):  
Jose M. Carnate ◽  
Audie G. Silva
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
S100 Protein ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Granular Cytoplasm ◽  
History Of ◽  
Infiltrative Growth Pattern ◽  
One Year

Granular cell tumors involving the trachea are rare. We present the case of a seventeen year old female with a one year history of gradually worsening dyspnea necessitating a tracheotomy. A suprastomal intraluminal tracheal mass was excised. Histologic sections (Figure 1) show a poorly circumscribed neoplasm infiltrating through the tracheal cartilage. It is composed of polygonal to somewhat elongated tumor cells that have small, dark nuclei. The cytoplasm is ample, eosinophilic and strikingly granular in quality. The cell borders are ill-defined creating a `syncytial’ pattern of dark nuclei scattered in a sea of granular cytoplasm. The diagnosis was a granular cell tumor. Immunohistochemistry (Figure 2) revealed strong, diffuse cytoplasmic positivity for S100 protein, attesting to its neural crest histogenesis. The infiltrative growth pattern may momentarily raise the question of malignancy but this is dispelled by awareness that infiltration is the natural history for all granular cell tumors, benign or malignant. Histologically, malignancy is diagnosed if three or more of the following are present: necrosis, spindling of tumor cells, vesicular nuclei with large nucleoli, greater than 2 mitoses per ten high power fields, high nucleus-to-cytoplasm ratio and nuclear pleomorphism. None was present in our case. Surgical excision remains the mainstay of treatment.

scholarly journals Granular Cell Tumor on the soft palate: a very rare location

2015 ◽  
Vol 21 (1) ◽  
pp. 58
Author(s):  
Willian Pecin Jacomacci
Keyword(s):  
Soft Palate ◽  
Granular Cell Tumor ◽  
Benign Lesion ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Neural Origin ◽  
Rare Location ◽  
Rare Lesion ◽  
Immunohistochemical Analyses

<p>Granular cell tumor (GCT) is a rare lesion of neural origin and uncertain nature. It can be a true neoplasm, a degenerative metabolic process or a proliferation trauma-induced. In general, it appears as a singular benign lesion, however, there are rare cases that are malignant multicentric forms. The most frequent orofacial localization is the tongue.  The aim of this report was to describe a case of GCT occurring on  the soft palate. Patient presented a discrete and asymptomatic nodule for approximately eight months. Definitive diagnosis of granular cell tumor was established by histological and immunohistochemical analyses. The case illustrates the occurrence of granular cell tumor in an unusual region and emphasizes the importance of including this entity in differential diagnosis of soft tissue tumors in otherwise locations besides the tongue. </p>

Ultrastructural study of a granular cell tumor from forearm

1984 ◽  
Vol 42 ◽  
pp. 676-677
Author(s):  
C.N. Sun ◽  
R. Shaefer
Keyword(s):  
Tumor Cells ◽  
Osmium Tetroxide ◽  
Granular Cell Tumor ◽  
White Male ◽  
Mesenchymal Cell ◽  
Granular Cell ◽  
Cell Tumor ◽  
Left Forearm ◽  
Tumor Mass ◽  
Fine Structures

Granular cell tumors are frequently reported in different body locations. Some authors believed it to be a neoplasm derived from skeletal muscle and others propose the origin of these lesions are from fibroblasts, histocytes, mesenchymal cell, neuron or Schwann cells. So far the tumor cells origin is still controversial. The purpose of this report is to present a case showing the cellular fine structures and to propose a possible origin of the tumor cells.A tumor mass (5 x 3 cm) from the left forearm of a 49 year old white male was removed, cut into small pieces (about 1 mm3), immediately fixed in 4 percent glutaraldehyde in phosphate buffer for 2 hours, and then post fixed in 1 percent buffered osmium tetroxide for 1 hour. After dehydration, tissues were embedded in Epon 812.

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