160 ANALGESIC AND ANTICONVULSIVE AGENTS AMONG DEITIFORIN DERIVATIVES

2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
V. Mamchur ◽  
L. Kasyan ◽  
H. Zlenko ◽  
S. Pridma ◽  
V. Palchikov
Keyword(s):  
Anticonvulsive Agents

Charcoal hemoperfusion in an infant with supraventricular tachycardia and seizures secondary to amitriptyline intoxication

2010 ◽  
Vol 30 (3) ◽  
pp. 254-256 ◽  
Author(s):  
Mehmet Mutlu ◽  
Gülay Karagüzel ◽  
Elif Bahat ◽  
Ayşe Aksoy ◽  
Burcu Güven ◽  
...  
Keyword(s):  
Supraventricular Tachycardia ◽  
Male Infant ◽  
Pediatric Emergency ◽  
Tricyclic Antidepressant ◽  
Common Causes ◽  
Shallow Breathing ◽  
Clonic Seizures ◽  
Charcoal Hemoperfusion ◽  
Anticonvulsive Agents ◽  
Narrow Complex Tachycardia

Tricyclic antidepressant (TCA) overdose is one of the common causes of drug poisoning and it has cardiovascular, respiratory and neurological side effects. An 18-month male infant was admitted to our pediatric emergency service due to poisoning with amitriptyline. The infant was unconscious. Tachycardia, irregular and shallow breathing, and tonic-clonic seizures were observed on physical examination. An electrocardiogram displayed a narrow complex tachycardia that was consistent with re-entrant supraventricular tachycardia (SVT). Although antiarrhythmic and anticonvulsive agents were administrated, SVT and seizures persisted. Charcoal hemoperfusion (HP) was performed for 4 hours. The infant’s clinical condition has improved after the charcoal HP, seizures and SVT were not observed. It is concluded that charcoal HP can be used efficiently in patients with severe amitriptyline intoxication.

Design and synthesis of anticonvulsive agents as γ-vinyl GABA-based potential dual acting prodrugs and their biological activities

2000 ◽  
Vol 10 (7) ◽  
pp. 609-613 ◽  
Author(s):  
Yong-chul Kim ◽  
Long-Xuan Zhao ◽  
Tae-Hyung Kim ◽  
Sun-mi Je ◽  
Eun-kyung Kim ◽  
...  
Keyword(s):  
Biological Activities ◽  
Design And Synthesis ◽  
Anticonvulsive Agents

Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents

2009 ◽  
Vol 19 (18) ◽  
pp. 5419-5422 ◽  
Author(s):  
Salvatore Genovese ◽  
Francesco Epifano ◽  
Massimo Curini ◽  
Monika Dudra-Jastrzebska ◽  
Jarogniew J. Luszczki
Keyword(s):  
Anticonvulsive Agents

Anticonvulsive agents (survey)

1979 ◽  
Vol 13 (11) ◽  
pp. 1129-1141
Author(s):  
M. S. Mashevskaya ◽  
P. A. Petyunin
Keyword(s):  
Anticonvulsive Agents

scholarly journals Eeg-analysis of the effect of combined use of carbamazepin and mexidolum on the epileptiform brain activity

1997 ◽  
Vol XXIX (1-2) ◽  
pp. 22-26
Author(s):  
О. L. Badalyan ◽  
L. N. Nerobkova ◽  
Т. А. Voronina ◽  
G. N. Avakyan
Keyword(s):  
Brain Activity ◽  
Eeg Analysis ◽  
System Effect ◽  
Anticonvulsive Effect ◽  
Combined Use ◽  
Effective Doses ◽  
Therapeutic Doses ◽  
Anticonvulsive Agents ◽  
Epileptic System

Experiments on rats with chronic epileptogenic fod in sensomotor region of cortex showed that effects of anticonvulsive agents depend on the progression phase of epileptic system. Effect of carbamasepinum in effective doses is mostly expressed during the phase of stable epileptic system with determinant foci in limbico-hypothalamic structures. Lowering the doses of the drug brings about a decrease of anticonvulsive effect and activation of the secondary hippocampal focus. Combined use of carbamazepin and mexidolum with membra-notropic antioxidantal activity bbrings about an increase of anticonvulsive properties of carbamazepin and allows to decrease the therapeutic doses of the last.

scholarly journals Treatment of Painful Diabetic Neuropathy—A Narrative Review of Pharmacological and Interventional Approaches

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 573
Author(s):  
Mayank Gupta ◽  
Nebojsa Nick Knezevic ◽  
Alaa Abd-Elsayed ◽  
Mahoua Ray ◽  
Kiran Patel ◽  
...  
Keyword(s):  
Pain Relief ◽  
Diabetic Neuropathy ◽  
Antidepressant Drugs ◽  
Intrathecal Therapy ◽  
Painful Diabetic Neuropathy ◽  
Prospective Data ◽  
Electrical Nerve Stimulation ◽  
Topical Capsaicin ◽  
Anticonvulsive Agents

Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus that is associated with a significant decline in quality of life. Like other painful neuropathic conditions, PDN is difficult to manage clinically, and a variety of pharmacological and non-pharmacological options are available for this condition. Recommended pharmacotherapies include anticonvulsive agents, antidepressant drugs, and topical capsaicin; and tapentadol, which combines opioid agonism and norepinephrine reuptake inhibition, has also recently been approved for use. Additionally, several neuromodulation therapies have been successfully used for pain relief in PDN, including intrathecal therapy, transcutaneous electrical nerve stimulation (TENS), and spinal cord stimulation (SCS). Recently, 10 kHz SCS has been shown to provide clinically meaningful pain relief for patients refractory to conventional medical management, with a subset of patients demonstrating improvement in neurological function. This literature review is intended to discuss the dosage and prospective data associated with pain management therapies for PDN.

scholarly journals Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2 heterotrimeric GABAA receptor in complex with GABA illuminates mechanism of receptor assembly and agonist binding

2018 ◽  
Author(s):  
Swastik Phulera ◽  
Hongtao Zhu ◽  
Jie Yu ◽  
Derek P. Claxton ◽  
Nate Yoder ◽  
...  
Keyword(s):  
Ion Channel ◽  
Rational Design ◽  
Neurological Diseases ◽  
Therapeutic Agents ◽  
Structural Studies ◽  
Agonist Binding ◽  
Mutant Forms ◽  
Receptor Assembly ◽  
Anticonvulsive Agents ◽  
Α1 Subunit

ABSTRACTFast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Native GABAA receptors are heteromeric assemblies sensitive to many important drugs, from sedatives to anesthetics and anticonvulsive agents, with mutant forms of GABAA receptors implicated in multiple neurological diseases, including epilepsy. Despite the profound importance of heteromeric GABAA receptors in neuroscience and medicine, they have proven recalcitrant to structure determination. Here we present the structure of the triheteromeric α1β1γ2EM GABAA receptor in complex with GABA, determined by single particle cryo-EM at 3.1-3.8 Å resolution, elucidating the molecular principles of receptor assembly and agonist binding. Remarkable N-linked glycosylation on the α1 subunit occludes the extracellular vestibule of the ion channel and is poised to modulate receptor assembly and perhaps ion channel gating. Our work provides a pathway to structural studies of heteromeric GABAA receptors and a framework for the rational design of novel therapeutic agents.

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