Pancreatic Elastase Induces Liver Injury by Activating Cytokine Production Within Kupffer Cells via Nuclear Factor-Kappa B,

2002 ◽  
Vol 6 (3) ◽  
pp. 474-480 ◽  
Author(s):  
M Murr
Keyword(s):  
Liver Injury ◽  
Kupffer Cells ◽  
Nuclear Factor Kappa B ◽  
Cytokine Production ◽  
Nuclear Factor ◽  
Pancreatic Elastase ◽  
Nuclear Factor Kappa

Dietary glycine inhibits activation of nuclear factor kappa B and prevents liver injury in hemorrhagic shock in the rat

2001 ◽  
Vol 31 (10) ◽  
pp. 1236-1244 ◽  
Author(s):  
J.L Mauriz ◽  
B Matilla ◽  
J.M Culebras ◽  
P González ◽  
J González-Gallego
Keyword(s):  
Liver Injury ◽  
Hemorrhagic Shock ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Dihydroresveratrol Improves Liver Injury in Septic Rats by Regulating Nuclear Factor-Kappa B Signaling Pathway

2021 ◽  
Vol 20 (1) ◽  
pp. 37-42
Author(s):  
Jinjing Hong ◽  
Jinchao Mao ◽  
Zhitao Zeng ◽  
Chunlian Ma ◽  
Miaoyao Lin ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathway ◽  
Inflammatory Process ◽  
Nuclear Factor Kappa B ◽  
Parasitic Infections ◽  
Nuclear Factor ◽  
Antitumor Effects ◽  
Nuclear Factor Kappa ◽  
Novel Drugs

Sepsis is a severe systemic inflammatory response syndrome caused by bacterial, fungal, viral, or parasitic infections. During sepsis, proinflammatory cytokines play a key role in initiating the inflammatory process. It is still urgently needed to develop novel drugs for sepsis treatment. Dihydroresveratrol is a polyphenol derivative belonging to phenylpropane, which has anti-inflammatory, antifibrosis, antiaging, and antitumor effects, whereas the role of dihydroresveratrol in sepsis is still unclear. In this study, we observed that dihydroresveratrol improved septic liver injury. We further observed that dihydroresveratrol decreased the expression of inflammatory cytokines and oxidative damage to rat liver tissues. Dihydroresveratrol improved liver injury in septic rats via regulating nuclear factor-kappa B signaling pathway.

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