Confirm Osteoporosis by Bone Biopsy in CKD Patients

The myelodysplastic syndrome-myeloproliferative neoplasms (MDS/MPNs) are defined by a group of heterogeneous hematological malignancies resulting from stem cell−driven clonal growth of pathological hematopoietic progenitors and ineffective hematopoiesis, they are characterized concomitant myelodysplastic and myeloproliferative signs. Myelodysplastic/myeloproliferative disorders have been considered to have a higher risk of thrombus formation.We report a rare case about a 64 years old Moroccan woman, experienced renal infarction (RI) associated with pulmonary embolism as a complication of a myelodysplastic/myeloproliferative disorder.The patient complained of acute-onset severe left flank pain, a contrast-enhanced computed tomography (CT) of the chest and abdomen revealed RI by a large wedge-shaped defect in the right kidney with pulmonary embolism.Biological exam showed deep anemia, the bone marrow aspiration found myelodysplasia.the bone biopsy showed signs of myeloproliferatif disease. The karyotype was normal, BCR-ABL, JAK2, CALR mutations were absents, and MPL mutation was positive. The International Prognostic Scoring System (IPSS-R) was 0, and the patient was included to the low risk group.Anticoagulation therapy was initiated with heparin to treat RI and pulmonary embolism. Three months later, pulmonary embolism had resolved without the appearance of additional peripheral infarction.This case emphasizes the need to consider myelodysplastic/myeloproliferative disorders as a cause of infraction renal and pulmonary embolism.

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Socket preservation using xenograft does not impair implant primary stability in sheep: clinical, histological and histomorphometric study

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00237 ◽

2020 ◽

Author(s):

Yaniv Mayer ◽

Ofir Ginesin ◽

Hadar Zigdon-Giladi

Keyword(s):

Bone Biopsy ◽

Primary Stability ◽

Insertion Torque ◽

Socket Preservation ◽

Histomorphometric Study ◽

Implant Placement ◽

High Bone ◽

Delayed Implant Placement ◽

Natural Healing

Implant primary stability, which depends mainly on the amount and quality of bone, is important for implant survival. Socket preservation aims to reduce bone volumetric changes following tooth extraction. This animal study aims to examine whether preserving a ridge by using xenograft impairs the primary stability of the implant. Eighteen artificial bone defects were prepared in four sheep (5mmØ and 8mm length). Defects were randomly grafted with xenografts: Bio-Oss (BO), Bioactive Bone (BB), or left for natural healing (control). After 8 weeks, bone biopsy was harvested and dental implants installed. During installation, peak insertion torque (IT) was measured by hand ratchet, and primary stability by the Osstell method. Histomorphometric analysis showed a higher percentage of new bone formation in the naturally healed defects compared to sites with xenograft (control 68.66 ± 4.5%, BB 48.75 ± 4.34%, BO 50.33 ± 4.0%). Connective tissue portion was higher in the BO and BB groups compared to control (44.25 ± 2.98%, 41 ± 6%, and 31.33 ± 4.5, p<0.05, respectively). Residual grafting material was similar in BO and BB (7 ± 2.44%, 8.66 ± 2.1 %, respectively). Mean IT and ISQ values were not statistically different among the groups. A positive correlation was found between IT and ISQ (r=0.65, p=0.00). In conclusion, previously grafted defects with xenograft did not influence primary stability and implant insertion torque in delayed implant placement. These results may be attributed to a relatively high bone fill of the defect (~50%) two months after grafting.

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629-P: Bedside Blind Bone Biopsy for Diagnosis of Diabetic Foot Osteitis Allows Similar Healing Rate as Conventional Bone Biopsy

Diabetes ◽

10.2337/db19-629-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 629-P

Author(s):

FLORINE FÉRON ◽

LOUIS POTIER ◽

GAUTHIER PÉAN DE PONFILLY ◽

DIANE-CÉ CILE GAUTHIER ◽

ANNE-LISE MUNIER ◽

...

Keyword(s):

Diabetic Foot ◽

Healing Rate ◽

Bone Biopsy

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Validation of Kinematic Registry and MRI Compatibility for Pediatric Surgical Robot with Modular Tooling for Bone Biopsy

10.31256/hsmr2018.42 ◽

2018 ◽

Author(s):

Alexander N Alvara ◽

◽

Thomas Looi ◽

Rami Saab ◽

Amanda Shorter ◽

...

Keyword(s):

Bone Biopsy ◽

Surgical Robot

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New method for bone biopsy.

American Journal of Roentgenology ◽

10.2214/ajr.155.3.2117379 ◽

1990 ◽

Vol 155 (3) ◽

pp. 658-658

Author(s):

D Cassel

Keyword(s):

Bone Biopsy ◽

New Method

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A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

Case Reports in Pediatrics ◽

10.1155/2018/1306824 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Ikuma Nozaki ◽

Yumi Tone ◽

Junko Yamanaka ◽

Hideko Uryu ◽

Yuko Shimizu-Motohashi ◽

...

Keyword(s):

Malignant Melanoma ◽

Malignant Transformation ◽

Poor Prognosis ◽

Mediastinal Mass ◽

Bone Biopsy ◽

Systematic Evaluation ◽

Anterior Mediastinal Mass ◽

Malignant Teratoma ◽

Experienced Pain

We report about a 14-year-old boy who presented with an anterior mediastinal mass that was diagnosed as malignant teratoma. Surgical resection was performed along with pre- and postoperative chemotherapy. Although elevated alpha-fetoprotein became negative, he experienced pain in his right hip joint 3 months after resection. Systematic evaluation revealed multiple locations of metastasis, and the pathological diagnosis based on bone biopsy was malignant melanoma originating from malignant teratoma, which rapidly progressed. He died 15 months after diagnosis of the original malignant teratoma. Diagnosing and treating malignant transformation of teratoma, including malignant melanoma, is difficult because it is very rare. To our knowledge, this is the second reported case of malignant melanoma arising from a mediastinum malignant teratoma, with both cases having a poor prognosis. In addition to the follow-up of tumor markers, systematic evaluation, including imaging, should be considered even after remission to monitor malignant transformation of teratoma. We expect to establish a successful therapy and improve mortality rate after more such cases are accumulated.

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Clinicoradiographic predictors of percutaneous bone biopsy results among patients with suspected thoracolumbar spine infection

Skeletal Radiology ◽

10.1007/s00256-021-03735-6 ◽

2021 ◽

Author(s):

My-Linh Nguyen ◽

Bhargavi Guddanti ◽

Marcos C. Schechter ◽

Monica Umpierrez ◽

Philip Wong ◽

...

Keyword(s):

Bone Biopsy ◽

Thoracolumbar Spine ◽

Spine Infection

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CT-guided bone biopsy using electron density maps from dual-energy CT

Radiology Case Reports ◽

10.1016/j.radcr.2021.06.009 ◽

2021 ◽

Vol 16 (9) ◽

pp. 2343-2346

Author(s):

Shota Yamamoto ◽

Shunsuke Kamei ◽

Kosuke Tomita ◽

Chikara Fujita ◽

Kazuyuki Endo ◽

...

Keyword(s):

Electron Density ◽

Bone Biopsy ◽

Dual Energy ◽

Dual Energy Ct ◽

Ct Guided ◽

Density Maps

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Differences in Radiation Exposure of CT-Guided Percutaneous Manual and Powered Drill Bone Biopsy

CardioVascular and Interventional Radiology ◽

10.1007/s00270-021-02851-z ◽

2021 ◽

Author(s):

Sebastian Zensen ◽

Sumitha Selvaretnam ◽

Marcel Opitz ◽

Denise Bos ◽

Johannes Haubold ◽

...

Keyword(s):

Radiation Exposure ◽

Diagnostic Yield ◽

Bone Biopsy ◽

Lumbar Vertebrae ◽

Bone Lesions ◽

Anatomical Location ◽

Thoracic Vertebrae ◽

Level Of Evidence ◽

Ct Guided ◽

Bone Biopsies

Abstract Purpose Apart from the commonly applied manual needle biopsy, CT-guided percutaneous biopsies of bone lesions can be performed with battery-powered drill biopsy systems. Due to assumably different radiation doses and procedural durations, the aim of this study is to examine radiation exposure and establish local diagnostic reference levels (DRLs) of CT-guided bone biopsies of different anatomical regions. Methods In this retrospective study, dose data of 187 patients who underwent CT-guided bone biopsy with a manual or powered drill biopsy system performed at one of three different multi-slice CT were analyzed. Between January 2012 and November 2019, a total of 27 femur (A), 74 ilium (B), 27 sacrum (C), 28 thoracic vertebrae (D) and 31 lumbar vertebrae (E) biopsies were included. Radiation exposure was reported for volume-weighted CT dose index (CTDIvol) and dose–length product (DLP). Results CTDIvol and DLP of manual versus powered drill biopsy were (median, IQR): A: 56.9(41.4–128.5)/66.7(37.6–76.2)mGy, 410(203–683)/303(128–403)mGy·cm, B: 83.5(62.1–128.5)/59.4(46.2–79.8)mGy, 489(322–472)/400(329–695)mGy·cm, C: 97.5(71.6–149.2)/63.1(49.1–83.7)mGy, 627(496–740)/404(316–515)mGy·cm, D: 67.0(40.3–86.6)/39.7(29.9–89.0)mGy, 392(267–596)/207(166–402)mGy·cm and E: 100.1(66.5–162.6)/62.5(48.0–90.0)mGy, 521(385–619)/315(240–452)mGy·cm. Radiation exposure with powered drill was significantly lower for ilium and sacrum, while procedural duration was not increased for any anatomical location. Local DRLs could be depicted as follows (CTDIvol/DLP): A: 91 mGy/522 mGy·cm, B: 90 mGy/530 mGy·cm, C: 116 mGy/740 mGy·cm, D: 87 mGy/578 mGy·cm and E: 115 mGy/546 mGy·cm. The diagnostic yield was 82.4% for manual and 89.4% for powered drill biopsies. Conclusion Use of powered drill bone biopsy systems for CT-guided percutaneous bone biopsies can significantly reduce the radiation burden compared to manual biopsy for specific anatomical locations such as ilium and sacrum and does not increase radiation dose or procedural duration for any of the investigated locations. Level of Evidence Level 3.

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