Mutagenicity assay in Salmonella and in vivo sister chromatid exchange in bone marrow cells of mice for four pyrazolone derivatives

1998 ◽  
Vol 420 (1-3) ◽  
pp. 15-25 ◽  
Author(s):  
A.K. Giri ◽  
A. Mukhopadhyay
Keyword(s):  
Bone Marrow ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Bone Marrow Cells ◽  
Pyrazolone Derivatives ◽  
Mutagenicity Assay ◽  
Marrow Cells

Environmental monitoring for genotoxicity: in vivo sister chromatid exchange in the house mouse (Mus musculus)

1985 ◽  
Vol 27 (3) ◽  
pp. 351-356 ◽  
Author(s):  
B. N. Nayak ◽  
M. L. Petras
Keyword(s):  
Bone Marrow ◽  
Sister Chromatid ◽  
Mus Musculus ◽  
Sister Chromatid Exchange ◽  
Bone Marrow Cells ◽  
Natural Populations ◽  
Wild Mice ◽  
Monitoring Procedure ◽  
Marrow Cells

Sister chromatid exchange (SCE) values were determined in bone marrow cells isolated from mouse (Mus musculus) femurs after injections of 5-bromo-2′-deoxyuridine (BrdU) and 5-fluorodeoxyuridine (FrdU). Male mice of C3H/J, C57BL/6J, and DBA/2 strains maintained in the laboratory gave mean SCE values of 3.42 ± 0.07, 3.62 ± 0.08, and 3.97 ± 0.13, respectively. Males obtained from natural populations of southwestern Ontario had a higher mean SCE value (6.02 ± 0.16), as did inbred males maintained in outdoor enclosures for at least 3 weeks (5.07 ± 0.22). Wild mice housed in the laboratory for 9 months or longer had SCE values similar to laboratory bred mice (3.46 ± 0.05). The SCE values in wild-caught mice were inversely proportional (r = −0.49) to the distance between the sites where these animals were collected and the nearest major industrial center. Based on these results, SCE analysis in mice is proposed as a possible first-line monitoring procedure for the detection of general changes in environmental genotoxicity.Key words: environmental genotoxicity, sister chromatid exchange, bone marrow cells, BrdU, FrdU, mouse.

The kinetics of in vivo sister chromatid exchange induction in mouse bone marrow cells by ethylnitrosourea and methylnitrosourea

1986 ◽  
Vol 84 (1) ◽  
pp. 56-65 ◽  
Author(s):  
James L. Charles ◽  
David Jacobson-Kram ◽  
Lyman W. Condie ◽  
Joseph F. Borzelleca ◽  
Richard A. Carchman
Keyword(s):  
Bone Marrow ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Bone Marrow Cells ◽  
Mouse Bone Marrow ◽  
Kinetics Of ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells
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