041 OBSTRUCTIVE SLEEP APNEA SYNDROME IN THE SAO PAULO EPIDEMIOLOGIC SLEEP STUDY

2009 ◽  
Vol 10 ◽  
pp. S11 ◽  
Author(s):  
S. Tufik ◽  
R. Santos-Silva ◽  
J.A. Taddei ◽  
L.R.A. Bittencourt
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Sao Paulo ◽  
São Paulo ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Obstructive Sleep Apnea Syndrome in the Sao Paulo Epidemiologic Sleep Study

2010 ◽  
Vol 11 (5) ◽  
pp. 441-446 ◽  
Author(s):  
Sergio Tufik ◽  
Rogerio Santos-Silva ◽  
Jose Augusto Taddei ◽  
Lia Rita Azeredo Bittencourt
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Sao Paulo ◽  
São Paulo ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Predictive factors facilitate identification of potential aortic dissection in patients with obstructive sleep apnea syndrome

2021 ◽  
Author(s):  
dinghui wu ◽  
Dandan Jiang ◽  
Qu Chen ◽  
xiangyang yao ◽  
chunping dong ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Aortic Dissection ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Sleep Study ◽  
Hypertensive Patients ◽  
Lymphocyte Ratio ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Objective: Investigating potential predictors of aortic dissection development in high-risk hypertensive patients with obstructive sleep apnea syndrome (OSAS). Methods: Hypertensive patients with aortic dissection, admitted to hospital between January 2010 and July 2020, was diagnosed with OSAS by overnight sleep study with polysomnography (PSG). Results: Male was liable to aortic dissection compared to female in both groups（84.7% and 86% respectively）.There were actually significant differences with regard to neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV) / platelet count (PLT) ratio and D-dimer that we concerned about and were of great value in aortic dissection as previously reported. As multivariable regression analysis revealed, NLR (odds rate [OR], 2.258, 95% confidence interval [CI], 1.464-3.482, P<0.05), MPV/PLT (OR, 2.743, 95%CI, 1.713-4.392, P<0.05) and apnea and hypopnea index (AHI) (OR, 1.746,95% CI, 1.225-1.320, P<0.05) were all independent risk factors for aortic dissection. receiver operating characteristic curves analysis of NLR, MPV/PLT, AHI and combination of indicators for aortic dissection revealed combination of NLR, MPV/PLT ratio and AHI is of outstanding predictive value with sensitivity of 0.904 and specificity of 0.847. At the thresholds of 4.41 for NLR and 5.14 for MPV/PLT and 35.95 for AHI, 87.5% of all studied patients were expected to be correctly diagnosed with regard to aortic dissection. Conclusion: Inflammation, platelet alteration is crucial for initiation and progression of aortic dissection. Combined detection of NLR, MPV/PLT ratio and AHI could assist sleep physicians to identify silent or potential aortic dissection in patient comorbidity OSAS and hypertension.

scholarly journals A Pharyngoplasty with a Dorsal Palatal Flap Expansion: The Evaluation of a Modified Surgical Treatment Method for Obstructive Sleep Apnea Syndrome—A Preliminary Report

2021 ◽  
Vol 10 (16) ◽  
pp. 3746
Author(s):  
Ewa Olszewska ◽  
Piotr Fiedorczuk ◽  
Adam Stróżyński ◽  
Agnieszka Polecka ◽  
Ewa Roszkowska ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Apnea Hypopnea Index ◽  
Upper Airways ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Surgical techniques for obstructive sleep apnea syndrome (OSAS) constantly evolve. This study aims to assess the effectiveness and safety of a new surgical approach for an OSAS pharyngoplasty with a dorsal palatal flap expansion (PDPFEx). A total of 21 participants (mean age 49.9; mean BMI 32.5) underwent a type III sleep study, an endoscopy of the upper airways, a filled medical history, a visual analog scale for snoring loudness, an Epworth Sleepiness Scale, and a Short Form Health Survey-36 questionnaire. A follow-up re-evaluation was performed 11 ± 4.9 months post-operatively. The study group (4 with moderate, 17 with severe OSAS) showed an improvement in all measured sleep study characteristics (p < 0.05), apnea-hypopnea index (pre-median 45.7 to 29.3 post-operatively, p = 0.009, r = 0.394), oxygen desaturation index (pre-median 47.7 and 23.3 post-operatively, p = 0.0005, r = 0.812), mean oxygen saturation (median 92% pre-operatively and median 94% post-operatively, p = 0.0002, r = 0.812), lowest oxygen saturation (p = 0.0001, r = 0.540) and time of sleep spent with blood oxygen saturation less than 90% (p = 0.0001, r = 0.485). The most commonly reported complications were throat dryness (11 patients) and minor difficulties in swallowing (5 patients transient, 3 patients constant). We conclude that a PDPFEx is a promising new surgical method; however, further controlled studies are needed to demonstrate its safety and efficacy for OSAS treatment in adults.

scholarly journals The Association of Oxidative Stress in the Uvular Mucosa with Obstructive Sleep Apnea Syndrome: A Clinical Study

2021 ◽  
Vol 10 (5) ◽  
pp. 1132
Author(s):  
Ewa Olszewska ◽  
Joanna Rogalska ◽  
Małgorzata M. Brzóska
Keyword(s):  
Oxidative Stress ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Apnea Hypopnea Index ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
Apnea Syndrome

The hypothesis that individuals with obstructive sleep apnea syndrome (OSAS) demonstrate oxidative stress in the uvular mucosa that correlates with OSAS occurrence was investigated. A total of 128 participants (mean age 45.8, mean body mass index 30.7, female–male ratio 1:20) were divided into the non-OSAS group (apnea–hypopnea index—AHI < 5) and OSAS-group (AHI ≥ 5), in which mild (5 ≤ AHI < 15), moderate (15 ≤ AHI < 30), and severe (AHI ≥ 30) sub-groups were distinguished. Laryngological examination, Epworth Sleep Scale questionnaire, and home sleep study were performed to obtain AHI, mean oxygen saturation, and lowest oxygen saturation. Total oxidative status (TOS) and total antioxidative status (TAS) were assayed in the uvular mucosa taken during palatoplasty or palatopharyngoplasty. The severity of oxidative stress was expressed as oxidative stress index (OSI). Oxidative/reductive imbalance was noted in the mucosa of the uvula of OSAS individuals, and TAS of the uvular mucosa negatively correlated with the severity of this syndrome. TOS and OSI in the mild, moderate, and severe OSAS were higher than in the non-OSAS group, whereas TAS of the uvular mucosa in the OSAS group was lower compared to the non-OSAS group. In conclusion, oxidative stress in the uvular mucosa is associated with the occurrence of OSAS.

Postoperative monitoring of children with obstructive sleep apnea syndrome

2014 ◽  
Vol 155 (18) ◽  
pp. 703-707 ◽  
Author(s):  
Pálma Benedek ◽  
Gabriella Kiss ◽  
Eszter Csábi ◽  
Gábor Katona
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Preoperative Evaluation ◽  
Sleep Apnea Syndrome ◽  
Study Patient ◽  
Severe Obstructive Sleep Apnea ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
Apnea Syndrome

Introduction: Treatment of pediatric obstructive sleep apnea syndrome is surgical. The incidence of postoperative respiratory complications in this population is 5–25%. Aim: The aim of the authors was to present the preoperative evaluation and monitoring procedure elaborated in Heim Pál Children Hospital, Budapest. Method: 142 patients were involved in the study. Patient history was obtained and physical examination was performed in all cases. Thereafter, polysomnography was carried out, the severity of the obstructive sleep apnea syndrome was determined, and the patients underwent tonsilloadenotomy. Results: 45 patients with mild, 50 patients with moderate and 47 patients with severe obstructive sleep apnea syndrome were diagnosed. There was no complication in patients with mild disease, while complications were observed in 6 patients in the moderate group and 24 patients in the severe group (desaturation, apnea, stridor, stop breathing) (p<0.000). In patients with severe obstructive sleep apnea syndrome, no significant difference was noted in preoperative apnoea-hypapnea index (p = 0.23) and in nadir oxygen saturation values (p = 0.73) between patients with and without complication. Conclusions: Patients with severe obstructive sleep apnea syndrome should be treated in hospital where pediatric intensive care unit is available. Orv. Hetil., 2014, 155(18), 703–707.

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