Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial

Ian E Krop; Sung-Bae Kim; Antonio Gonzalez Martin; Patricia M LoRusso; Jean-Marc Ferrero; Tanja Badovinac-Crnjevic; Silke Hoersch; Melanie Smitt; Hans Wildiers

doi:10.1016/s1470-2045(17)30313-3

Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial

The Lancet Oncology ◽

10.1016/s1470-2045(17)30313-3 ◽

2017 ◽

Vol 18 (6) ◽

pp. 743-754 ◽

Cited By ~ 144

Author(s):

Ian E Krop ◽

Sung-Bae Kim ◽

Antonio Gonzalez Martin ◽

Patricia M LoRusso ◽

Jean-Marc Ferrero ◽

...

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Metastatic Breast ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Open Label ◽

Phase 3 ◽

Open Label Phase ◽

Previously Treated ◽

Versus Treatment

Download Full-text

Abstract S5-05: Trastuzumab emtansine improves overall survival versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer: Final overall survival results from the phase 3 TH3RESA study

10.1158/1538-7445.sabcs15-s5-05 ◽

2016 ◽

Cited By ~ 8

Author(s):

H Wildiers ◽

S-B Kim ◽

A Gonzalez-Martin ◽

PM LoRusso ◽

J-M Ferrero ◽

...

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Metastatic Breast Cancer ◽

Metastatic Breast ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Phase 3 ◽

Previously Treated ◽

Versus Treatment

Download Full-text

Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial

The Lancet Oncology ◽

10.1016/s1470-2045(17)30312-1 ◽

2017 ◽

Vol 18 (6) ◽

pp. 732-742 ◽

Cited By ~ 169

Author(s):

Véronique Diéras ◽

David Miles ◽

Sunil Verma ◽

Mark Pegram ◽

Manfred Welslau ◽

...

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Advanced Breast Cancer ◽

Descriptive Analysis ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Open Label ◽

Phase 3 ◽

Open Label Phase ◽

Previously Treated

Download Full-text

Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial

The Lancet Oncology ◽

10.1016/s1470-2045(14)70178-0 ◽

2014 ◽

Vol 15 (7) ◽

pp. 689-699 ◽

Cited By ~ 350

Author(s):

Ian E Krop ◽

Sung-Bae Kim ◽

Antonio González-Martín ◽

Patricia M LoRusso ◽

Jean-Marc Ferrero ◽

...

Keyword(s):

Breast Cancer ◽

Advanced Breast Cancer ◽

Advanced Breast ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Open Label ◽

Phase 3 ◽

Open Label Phase ◽

Versus Treatment

Download Full-text

Faculty Opinions recommendation of Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718373656.793494835 ◽

2014 ◽

Author(s):

Ana Maria Gonzalez-Angulo

Keyword(s):

Breast Cancer ◽

Advanced Breast Cancer ◽

Advanced Breast ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Open Label ◽

Phase 3 ◽

Open Label Phase ◽

Versus Treatment

Download Full-text

A randomized, open-label, Phase III trial of pertuzumab retreatment in HER2-positive locally advanced/metastatic breast cancer patients previously treated with pertuzumab, trastuzumab and chemotherapy: the Japan Breast Cancer Research Group-M05 PRECIOUS study

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyy097 ◽

2018 ◽

Vol 48 (9) ◽

pp. 855-859 ◽

Cited By ~ 2

Author(s):

Yutaka Yamamoto ◽

Hiroji Iwata ◽

Takayuki Ueno ◽

Naruto Taira ◽

Masahiro Kashiwaba ◽

...

Keyword(s):

Breast Cancer ◽

Locally Advanced ◽

Metastatic Breast ◽

Phase Iii ◽

Breast Cancer Patients ◽

Her2 Positive ◽

Open Label ◽

Phase Iii Trial ◽

Open Label Phase ◽

Previously Treated

Download Full-text

Abstract OT3-01-01: HERMIONE: A phase 2, randomized, open label trial comparing MM-302 plus trastuzumab with chemotherapy of physician's choice plus trastuzumab, in anthracycline naive HER2-positive, locally advanced/metastatic breast cancer patients previously treated with pertuzumab and ado-trastuzumab emtansine (T-DM1)

10.1158/1538-7445.sabcs15-ot3-01-01 ◽

2016 ◽

Author(s):

K Miller ◽

J Cortes ◽

SA Hurvitz ◽

IE Krop ◽

D Tripathy ◽

...

Keyword(s):

Breast Cancer ◽

Locally Advanced ◽

Metastatic Breast ◽

Trastuzumab Emtansine ◽

Phase 2 ◽

Breast Cancer Patients ◽

Her2 Positive ◽

Open Label ◽

Previously Treated ◽

Open Label Trial

Download Full-text

Abstract P4-14-01: Trastuzumab emtansine improves overall survival versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer: Final results from the phase 3 EMILIA study

10.1158/1538-7445.sabcs15-p4-14-01 ◽

2016 ◽

Author(s):

V Diéras ◽

D Miles ◽

S Verma ◽

M Pegram ◽

M Welslau ◽

...

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Advanced Breast Cancer ◽

Advanced Breast ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Phase 3 ◽

Previously Treated

Download Full-text

HERMIONE: A Phase 2, randomized, open label trial comparing MM-302 plus trastuzumab with chemotherapy of physician’s choice plus trastuzumab, in anthracycline naive HER2-positive, locally advanced/metastatic breast cancer patients previously treated with pertuzumab and ado-trastuzumab emtansine (T-DM1).

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.tps641 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. TPS641-TPS641 ◽

Cited By ~ 2

Author(s):

Kathy Miller ◽

Javier Cortes ◽

Sara A. Hurvitz ◽

Ian E. Krop ◽

Debu Tripathy ◽

...

Keyword(s):

Breast Cancer ◽

Locally Advanced ◽

Metastatic Breast ◽

Trastuzumab Emtansine ◽

Phase 2 ◽

Breast Cancer Patients ◽

Her2 Positive ◽

Open Label ◽

Previously Treated ◽

Open Label Trial

Download Full-text

OT3-01-07: The BEACON Study (BrEAst Cancer Outcomes with NKTR-102): A Phase 3 Open-Label, Randomized, Multicenter Study of NKTR-102 Versus Treatment of Physician's Choice (TPC) in Patients (pts) with Locally Recurrent or Metastatic Breast Cancer (MBC) Previously Treated with an Anthracycline, a Taxane, and Capecitabine (ATC).

10.1158/0008-5472.sabcs11-ot3-01-07 ◽

2011 ◽

Author(s):

A Awada ◽

ACF Leung ◽

C Zhao ◽

AL Hannah ◽

EA Perez

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Multicenter Study ◽

Metastatic Breast ◽

Open Label ◽

Phase 3 ◽

Breast Cancer Outcomes ◽

Previously Treated ◽

Locally Recurrent ◽

Versus Treatment

Download Full-text

Relationship between tumor biomarkers (BM) and efficacy in TH3RESA, a phase 3 study of trastuzumab emtansine (T-DM1) versus treatment of physician’s choice (TPC) in HER2-positive advanced breast cancer (BC) previously treated with trastuzumab and lapatinib.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.605 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 605-605 ◽

Cited By ~ 3

Author(s):

Sung-Bae Kim ◽

Hans Wildiers ◽

Ian E. Krop ◽

Abraham C.F. Leung ◽

Caroline Trudeau ◽

...

Keyword(s):

Breast Cancer ◽

Advanced Breast Cancer ◽

Advanced Breast ◽

Tumor Biomarkers ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Phase 3 ◽

Previously Treated ◽

Versus Treatment

Download Full-text