Abstract #1166: Medullary Thyroid Carcinoma: Diagnostic Challenges of Fine Needle Aspiration Cytology – Case Presentation of a Woman with a Thyroid Nodule and Eventual Diagnosis of Multiple Endocrine Neoplasia Type 2

2016 ◽  
Vol 22 ◽  
pp. 284-285
Author(s):  
Samuel Olatunbosun ◽  
Brent Huddleston
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Case Presentation ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Endocrine Neoplasia ◽  
Needle Aspiration Cytology

scholarly journals Usefulness of preoperative serum calcitonin in patients with nodular thyroid disease without suspicious history or cytology for medullary thyroid carcinoma

2013 ◽  
Vol 57 (4) ◽  
pp. 312-316 ◽  
Author(s):  
Pedro Weslley Rosário ◽  
Gustavo Cancela Penna ◽  
Kamilla Brandão ◽  
Bárbara Érika Souza
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Endocrine Neoplasia ◽  
Preoperative Serum ◽  
History Of

OBJECTIVE: To evaluate the usefulness of preoperative serum calcitonin (sCT) in patients with nodular disease without suspicion of medullary thyroid carcinoma (MTC) in history or cytology. PATIENTS AND METHODS: sCT was measured before thyroidectomy in 494 patients with nodular disease who had no family history of MTC or multiple endocrine neoplasia type 2, and no cytological suspicion of MTC. RESULTS: Basal sCT was < 10 ng/mL in 482 patients and none of them had MTC. One patient with basal sCT > 100 pg/mL had MTC. Among the 11 patients with basal sCT between 10 and 100 pg/mL, MTC was diagnosed in only one. The two patients with MTC were submitted to total thyroidectomy, combined with elective lymph node dissection indicated exclusively based on hypercalcitoninemia, and sCT was undetectable after six months. CONCLUSIONS: Preoperative sCT is useful for the detection of sporadic MTC in patients with nodular disease, even in the absence of suspicious history or cytology.

Diagnosis of pseudopapillary variant of medullary thyroid carcinoma by fine-needle aspiration cytology

2013 ◽  
Vol 42 (9) ◽  
pp. 823-826 ◽  
Author(s):  
Namiki Kawanishi ◽  
Yoshiaki Norimatsu ◽  
Hiroyuki Ohsaki ◽  
Tsutomu Yuminamochi ◽  
Ryohei Katoh ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Needle Aspiration Cytology

scholarly journals Amplification and Overexpression of Mutant RET in Multiple Endocrine Neoplasia Type 2-Associated Medullary Thyroid Carcinoma

2003 ◽  
Vol 88 (1) ◽  
pp. 459-463 ◽  
Author(s):  
Steve C. Huang ◽  
Joshua Torres-Cruz ◽  
Svetlana D. Pack ◽  
Christian A. Koch ◽  
Alexander O. Vortmeyer ◽  
...  
Keyword(s):  
Cell Line ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Wild Type ◽  
Medullary Thyroid ◽  
Second Hit ◽  
Men 2 ◽  
Endocrine Neoplasia ◽  
Associated Tumors

We have previously identified two second hit mechanisms involved in the development of multiple endocrine neoplasia type 2 (MEN 2)-associated tumors: trisomy 10 with duplication of the mutant RET allele and loss of the wild-type RET allele. However, some of the MEN 2-associated tumors investigated did not demonstrate either mechanism. Here, we studied the TT cell line derived from MEN 2-associated medullary thyroid carcinoma with a RET germline mutation in codon 634, for alternative mechanisms of tumorigenesis. Although we observed a 2:1 ratio between mutant and wild-type RET at the genomic DNA level in this cell line, fluorescence in situ hybridization analysis revealed neither trisomy 10 nor loss of the normal chromosome 10. Instead, a tandem duplication event was responsible for amplification of mutant RET. In further studies we could for the first time demonstrate that the genomic chromosome 10 abnormalities in this cell line cause an increased production of mutant RET mRNA. These findings provide evidence for a third second hit mechanism resulting in overrepresentation and overexpression of mutant RET in MEN 2-associated tumors.

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