Do ATP and UTP involve cGMP in positive inotropism on rat atria?

2001 ◽  
Vol 128 (2) ◽  
pp. 265-274 ◽  
Author(s):  
Guglielmina Froldi ◽  
Eugenio Ragazzi ◽  
Laura Caparrotta
Keyword(s):  
Rat Atria ◽  
Positive Inotropism

Papaverine-induced positive inotropism with failure to increase cyclic AMP in rat atria

1986 ◽  
Vol 131 (1) ◽  
pp. 141-144
Author(s):  
Pedro Aramendía ◽  
Claudio D. Eisenschlos ◽  
María T. Márquez
Keyword(s):  
Cyclic Amp ◽  
Rat Atria ◽  
Positive Inotropism

An adrenergic participation subserving a positive inotropism and chronotropism of prostacyclin on isolated rat atria

1979 ◽  
Vol 35 (4) ◽  
pp. 529-530 ◽  
Author(s):  
L. S. Borda ◽  
L. Cangas ◽  
M. F. Gimeno ◽  
A. L. Gimeno
Keyword(s):  
Rat Atria ◽  
Positive Inotropism ◽  
Isolated Rat

Positive inotropism in hypothermia partially depends on an increase in maximal Ca(2+)-activated force

1991 ◽  
Vol 261 (4) ◽  
pp. H1005-H1010 ◽  
Author(s):  
H. Kusuoka ◽  
Y. Ikoma ◽  
S. Futaki ◽  
H. Suga ◽  
A. Kitabatake ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Oxygen Consumption ◽  
Mild Hypothermia ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Phosphorus Compounds ◽  
Resonance Spectroscopy ◽  
Positive Inotropism ◽  
Rapid Pacing ◽  
Intact Heart

We investigated the contribution of maximal Ca(2+)-activated force to the positive inotropism induced by mild hypothermia. Phosphorus-31 nuclear magnetic resonance spectroscopy revealed that neither energy-related phosphorus compounds in myocardium nor intracellular pH was responsible for the change in contractility. Maximal Ca(2+)-activated pressure (MCAP), the intact-heart correlate of maximal Ca(2+)-activated force, was determined in isolated perfused rabbit hearts by measuring isovolumic left ventricular pressure during tetani at extracellular Ca2+ concentrations greater than or equal to 10 mM. Tetani were elicited by rapid pacing after exposure to ryanodine. MCAP increased by 2.17 +/- 0.28% (mean +/- SE, P less than 0.001, n = 19) for each degree of myocardial cooling between 30 and 38 degrees C. Our results indicate that a primary change in myofilament Ca2+ responsiveness underlies the positive inotropism in hypothermia. The increase in maximal Ca(2+)-activated force may explain the observation of positive inotropism without an upward shift in the relation between oxygen consumption and pressure-volume area, as previously reported for cooled whole hearts.

Protein synthesis in isolated, beating rat atria

1969 ◽  
Vol 25 (10) ◽  
pp. 1029-1030 ◽  
Author(s):  
A. A. Whitbeck ◽  
J. Cohen
Keyword(s):  
Protein Synthesis ◽  
Rat Atria

Cardiac Stimulant Action of Extracts of Coelenterates on Rat Atria

1974 ◽  
Vol 63 (8) ◽  
pp. 1332-1333 ◽  
Author(s):  
S. Shibata ◽  
D.F. Dunn ◽  
M. Kuchii ◽  
M. Kashiwagi ◽  
T.R. Norton
Keyword(s):  
Rat Atria
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