An Automated Liquid-Liquid Extraction System Supervised by an Industrial Programmable Logic Controller

Author(s):  
S Bostyn
2000 ◽  
Vol 39 (12) ◽  
pp. 4986-4990 ◽  
Author(s):  
Syouhei Nishihama ◽  
Nobuya Sakaguchi ◽  
Takayuki Hirai ◽  
Isao Komasawa

2018 ◽  
Vol 26 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Daiana Wischral ◽  
Hongxin Fu ◽  
Fernando L. Pellegrini Pessoa ◽  
Nei Pereira ◽  
Shang-Tian Yang

2016 ◽  
Vol 284 ◽  
pp. 764-777 ◽  
Author(s):  
Safa Kutup Kurt ◽  
Iris Vural Gürsel ◽  
Volker Hessel ◽  
Krishna D.P. Nigam ◽  
Norbert Kockmann

2000 ◽  
Vol 22 (6) ◽  
pp. 187-194 ◽  
Author(s):  
Eugene Maslana ◽  
Robert Schmitt ◽  
Jeffrey Pan

The development of the Abbott Liquid-Liquid Extraction Station was a result of the need for an automated system to perform aqueous extraction on large sets of newly synthesized organic compounds used for drug discovery. The system utilizes a cylindrical laboratory robot to shuttle sample vials between two loading racks, two identical extraction stations, and a centrifuge. Extraction is performed by detecting the phase interface (by difference in refractive index) of the moving column of fluid drawn from the bottom of each vial containing a biphasic mixture. The integration of interface detection with fluid extraction maximizes sample throughput. Abbott-developed electronics process the detector signals. Sample mixing is performed by high-speed solvent injection. Centrifuging of the samples reduces interface emulsions. Operating software permits the user to program wash protocols with any one of six solvents per wash cycle with as many cycle repeats as necessary. Station capacity is eighty, 15 ml vials. This system has proven successful with a broad spectrum of both ethyl acetate and methylene chloride based chemistries. The development and characterization of this automated extraction system will be presented.


2016 ◽  
Vol 120 (10) ◽  
pp. 2814-2823 ◽  
Author(s):  
O. Pecheur ◽  
S. Dourdain ◽  
D. Guillaumont ◽  
J. Rey ◽  
P. Guilbaud ◽  
...  

2006 ◽  
Vol 556 (1) ◽  
pp. 151-156 ◽  
Author(s):  
Zeng-Xuan Cai ◽  
Qun Fang ◽  
Heng-Wu Chen ◽  
Zhao-Lun Fang

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