PO15-416 BRACHIAL ENDOTHELIAL FUNCTION IN SUBJECTS WITH FAMILIAL COMBINED HYPERLIPIDEMIA AND ITS RELATIONSHIPS TO CAROTID ARTERY INTIMA-MEDIA THICKNESS

2007 ◽  
Vol 8 (1) ◽  
pp. 119-120
Author(s):  
D. Karasek ◽  
H. Vaverkova ◽  
M. Halenka ◽  
M. Budikova ◽  
D. Novotny
Keyword(s):  
Carotid Artery ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Familial Combined Hyperlipidemia ◽  
Media Thickness

Deletion polymorphism in the α2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery

2002 ◽  
Vol 103 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Paula HEINONEN ◽  
Laura JARTTI ◽  
Mikko J. JÄRVISALO ◽  
Ullamari PESONEN ◽  
Jaakko A. KAPRIO ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Endothelial Function ◽  
Brachial Artery ◽  
Adrenergic Receptor ◽  
Intima Media Thickness ◽  
Deletion Variant ◽  
Media Thickness ◽  
Increased Risk ◽  
Flow Mediated Dilatation ◽  
Carotid Artery Compliance

A deletion variant of the α2B-adrenergic receptor (α2B-AR) has been associated with an increased risk of acute cardiac events in middle-aged men. Our aim was to determine the possible associations between the α2B-AR gene deletion variant and indicators of subclinical atherosclerosis in the brachial and carotid arteries. A total of 148 middle-aged men participating in an epidemiological twin study on risk factors for subclinical coronary heart disease were genotyped using PCR. Flow-mediated dilatation (FMD) of the brachial artery, carotid artery compliance and carotid intima-media thickness were measured using high-resolution ultrasound. FMD was 6.2±5.0% in subjects with the I/I (insertion/insertion) genotype, 5.5±4.1% in the I/D (insertion/deletion) group and 4.1±3.8% in the D/D (deletion/deletion) group (P = 0.03 for trend). In multivariate regression analysis controlling for age, presence of hypertension, smoking, use of angiotensin-converting enzyme inhibitors and plasma levels of low-density lipoprotein cholesterol and lipoprotein (a), the association between the α2B-AR genotype and FMD remained significant (P = 0.04 for trend). The α2B-AR genotype was not associated with intima-media thickness or carotid artery compliance. These findings indicate that subjects homozygous for the deletion allele of α2B-AR appear to have an increased risk of impaired endothelial function, which may provide an explanation for the previously observed increased risk of myocardial infarction in male subjects with this genotype. It is not known whether the association of the α2B-AR polymorphism with endothelial function is direct, or is mediated via altered sympathetic activation.

scholarly journals Specific cell-derived microvesicles: Linking endothelial function to carotid artery intima-media thickness in low cardiovascular risk menopausal women

2016 ◽  
Vol 246 ◽  
pp. 21-28 ◽  
Author(s):  
Virginia M. Miller ◽  
Brian D. Lahr ◽  
Kent R. Bailey ◽  
Howard N. Hodis ◽  
Sharon L. Mulvagh ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Specific Cell ◽  
Media Thickness ◽  
Menopausal Women ◽  
Low Cardiovascular Risk

scholarly journals Increase in Carotid Artery Intima‐Media Thickness and Arterial Stiffness but Improvement in Several Markers of Endothelial Function after Initiation of Antiretroviral Therapy

2009 ◽  
Vol 199 (8) ◽  
pp. 1186-1194 ◽  
Author(s):  
Marit G. A. van Vonderen ◽  
Elly A. M. Hassink ◽  
Michiel A. van Agtmael ◽  
Coen D. A. Stehouwer ◽  
Sven A. Danner ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Media Thickness

scholarly journals EFFECT OF PRE-HYPERTENSION ON ENDOTHELIAL FUNCTION AND INTIMA MEDIA THICKNESS OF THE CAROTID ARTERY IN AFRICAN AMERICANS

2011 ◽  
Vol 57 (14) ◽  
pp. E588
Author(s):  
Abul Kashem ◽  
Praveen Veerabhadrappa ◽  
Deb Feairheller ◽  
Keith Diaz ◽  
Sheara Williamson ◽  
...  
Keyword(s):  
African Americans ◽  
Carotid Artery ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Media Thickness

scholarly journals Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis

2009 ◽  
Vol 23 (1) ◽  
pp. 1-6 ◽  
Author(s):  
DD Balci ◽  
A Balci ◽  
S Karazincir ◽  
E Ucar ◽  
U Iyigun ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Media Thickness
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