scholarly journals ePS04.8 Effect of early intervention with inhaled hypertonic saline on lung function in infants and toddlers with cystic fibrosis (CF) diagnosed by neonatal screening

2015 ◽  
Vol 14 ◽  
pp. S49 ◽  
Author(s):  
A. Teper ◽  
J. Balinotti ◽  
V. Rodríguez ◽  
S. Zaragoza ◽  
S. Lubovich ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Early Intervention ◽  
Lung Function ◽  
Hypertonic Saline ◽  
Neonatal Screening ◽  
Infants And Toddlers

scholarly journals Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: short-term tolerability, adherence, and safety

2011 ◽  
Vol 46 (7) ◽  
pp. 666-671 ◽  
Author(s):  
Margaret Rosenfeld ◽  
Stephanie Davis ◽  
Lyndia Brumback ◽  
Stephen Daniel ◽  
Ron Rowbotham ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Infants And Toddlers ◽  
Short Term ◽  
Term Tolerability

scholarly journals Mucus Clearance and Lung Function in Cystic Fibrosis with Hypertonic Saline

2006 ◽  
Vol 354 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Scott H. Donaldson ◽  
William D. Bennett ◽  
Kirby L. Zeman ◽  
Michael R. Knowles ◽  
Robert Tarran ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Hypertonic Saline ◽  
Mucus Clearance

Erratum: Growth and long-term lung function in cystic fibrosis: A longitudinal study of patients diagnosed by neonatal screening

2009 ◽  
Vol 44 (5) ◽  
pp. 517-518
Author(s):  
Baroukh Maurice Assael ◽  
Giovanni Casazza ◽  
Patrizia Iansa ◽  
Sonia Volpi ◽  
Silvano Milani
Keyword(s):  
Cystic Fibrosis ◽  
Longitudinal Study ◽  
Lung Function ◽  
Neonatal Screening

scholarly journals Lung function in children with cystic fibrosis in the USA and UK: a comparative longitudinal analysis of national registry data

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2021-216849
Author(s):  
Daniela K Schlüter ◽  
Josh S Ostrenga ◽  
Siobhán B Carr ◽  
Aliza K Fink ◽  
Albert Faro ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Hypertonic Saline ◽  
Early Growth ◽  
National Registry ◽  
Cross Sectional ◽  
Growth And Nutrition ◽  
Inhaled Antibiotics ◽  
The Usa ◽  
The Uk

RationaleA previous analysis found significantly higher lung function in the US paediatric cystic fibrosis (CF) population compared with the UK with this difference apparently decreasing in adolescence and adulthood. However, the cross-sectional nature of the study makes it hard to interpret these results.ObjectivesTo compare longitudinal trajectories of lung function in children with CF between the USA and UK and to explore reasons for any differences.MethodsWe used mixed effects regression analysis to model lung function trajectories in the study populations. Using descriptive statistics, we compared early growth and nutrition (height, weight, body mass index), infections (Pseudomonas aeruginosa, Staphylococcus aureus) and treatments (rhDnase, hypertonic saline, inhaled antibiotics).ResultsWe included 9463 children from the USA and 3055 children from the UK with homozygous F508del genotype. Lung function was higher in the USA than in the UK when first measured at age six and remained higher throughout childhood. We did not find important differences in early growth and nutrition, or P.aeruginosa infection. Prescription of rhDNase and hypertonic saline was more common in the USA. Inhaled antibiotics were prescribed at similar levels in both countries, but Tobramycin was prescribed more in the USA and colistin in the UK. S. aureus infection was more common in the USA than the UK.ConclusionsChildren with CF and homozygous F508del genotype in the USA had better lung function than UK children. These differences do not appear to be explained by early growth or nutrition, but differences in the use of early treatments need further investigation.

Sign in / Sign up

Export Citation Format

Share Document