scholarly journals Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: short-term tolerability, adherence, and safety

2011 ◽  
Vol 46 (7) ◽  
pp. 666-671 ◽  
Author(s):  
Margaret Rosenfeld ◽  
Stephanie Davis ◽  
Lyndia Brumback ◽  
Stephen Daniel ◽  
Ron Rowbotham ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Infants And Toddlers ◽  
Short Term ◽  
Term Tolerability

Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis

1996 ◽  
Vol 21 (2) ◽  
pp. 77-83 ◽  
Author(s):  
P.A. Eng ◽  
J. Morton ◽  
J.A. Douglass ◽  
J. Riedler ◽  
J. Wilson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Short Term ◽  
Term Efficacy

scholarly journals WS21.3 Short-term effects of hypertonic saline nebulization combined with oscillatory positive expiratory pressure in cystic fibrosis: randomised crossover trial

2016 ◽  
Vol 15 ◽  
pp. S33 ◽  
Author(s):  
B. Herrero Cortina ◽  
M. San Miguel Pagola ◽  
M.À. Cebrià i Iranzo ◽  
M. Gomez Romero ◽  
F. Diaz Gutierrez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Hypertonic Saline ◽  
Crossover Trial ◽  
Short Term ◽  
Positive Expiratory Pressure ◽  
Short Term Effects

scholarly journals A short-term evaluation of a prototype disposable Oscillating Positive Expiratory Pressure (OPEP) device in a cohort of children with cystic fibrosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kevin J. O’Sullivan ◽  
Valerie Power ◽  
Barry Linnane ◽  
Deirdre McGrath ◽  
Magdalena Mulligan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Clinical Investigation ◽  
Mean Difference ◽  
Short Term ◽  
Intervention Participant ◽  
Post Intervention ◽  
Convenience Sample ◽  
Disposable Device ◽  
Positive Expiratory Pressure

Abstract Background Oscillating Positive Expiratory Pressure (OPEP) devices are important adjuncts to airway clearance therapy in patients with cystic fibrosis (CF). Current devices are typically reusable and require daily, or often more frequent, cleaning to prevent risk of infection by acting as reservoirs of potentially pathogenic organisms. In response, a daily disposable OPEP device, the UL-OPEP, was developed to mitigate the risk of contamination and eliminate the burdensome need for cleaning devices. Methods A convenience sample of 36 participants, all current OPEP device users, was recruited from a paediatric CF service. For one month, participants replaced their current OPEP device with a novel daily disposable device. Assessment included pre- and post-intervention lung function by spirometry, as well as Lung Clearance Index. Quality of life was assessed using the Cystic Fibrosis Questionnaire – Revised, while user experience was evaluated with a post-study survey. Results 31 participants completed the study: 18 males; median age 10 years, range 4–16 years. Lung function (mean difference ± SD, %FEV1 = 1.69 ± 11.93; %FVC = 0.58 ± 10.04; FEV1: FVC = 0.01 ± 0.09), LCI (mean difference ± SD, 0.08 ± 1.13), six-minute walk test, and CFQ-R were unchanged post-intervention. Participant-reported experiences of the device were predominantly positive. Conclusions The disposable OPEP device maintained patients’ lung function during short term use (≤ 1 month), and was the subject of positive feedback regarding functionality while reducing the risk of airway contamination associated with ineffective cleaning. Registration The study was approved as a Clinical Investigation by the Irish Health Products Regulatory Authority (CRN-2209025-CI0085).

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