scholarly journals 168: Lung clearance index and spirometry in cystic fibrosis: Enemies or friends?

2021 ◽  
Vol 20 ◽  
pp. S83
Author(s):  
M. De Marchis ◽  
E. Montemitro ◽  
L. Cristiani ◽  
B. Giacomodonato ◽  
F. Ciciriello ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout

2018 ◽  
Vol 52 (5) ◽  
pp. 1800821 ◽  
Author(s):  
Laurie J. Smith ◽  
Guilhem J. Collier ◽  
Helen Marshall ◽  
Paul J.C. Hughes ◽  
Alberto M. Biancardi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Total Lung Capacity ◽  
Resonance Imaging ◽  
Ventilation Distribution ◽  
Lung Clearance ◽  
Lung Capacity ◽  
Lung Clearance Index ◽  
Ventilation Heterogeneity ◽  
Multiple Breath Washout

Hyperpolarised helium-3 (3He) ventilation magnetic resonance imaging (MRI) and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). We aimed to explore their relationship across a broad range of CF disease severity and patient age, as well as assess the effect of inhaled lung volume on ventilation distribution.32 children and adults with CF underwent MBW and 3He-MRI at a lung volume of end-inspiratory tidal volume (EIVT). In addition, 28 patients performed 3He-MRI at total lung capacity. 3He-MRI scans were quantitatively analysed for ventilation defect percentage (VDP), ventilation heterogeneity index (VHI) and the number and size of individual contiguous ventilation defects. From MBW, the lung clearance index, convection-dependent ventilation heterogeneity (Scond) and convection–diffusion-dependent ventilation heterogeneity (Sacin) were calculated.VDP and VHI at EIVT strongly correlated with lung clearance index (r=0.89 and r=0.88, respectively), Sacin (r=0.84 and r=0.82, respectively) and forced expiratory volume in 1 s (FEV1) (r=−0.79 and r=−0.78, respectively). Two distinct 3He-MRI patterns were highlighted: patients with abnormal FEV1 had significantly (p<0.001) larger, but fewer, contiguous defects than those with normal FEV1, who tended to have numerous small volume defects. These two MRI patterns were delineated by a VDP of ∼10%. At total lung capacity, when compared to EIVT, VDP and VHI reduced in all subjects (p<0.001), demonstrating improved ventilation distribution and regions of volume-reversible and nonreversible ventilation abnormalities.

Six‐minute walk, lung clearance index, and QOL in bronchiolitis obliterans and cystic fibrosis

2018 ◽  
Vol 54 (4) ◽  
pp. 451-456 ◽  
Author(s):  
Michal Gur ◽  
Kamal Masarweh ◽  
Yazeed Toukan ◽  
Vered Nir ◽  
Ronen Bar‐Yoseph ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Bronchiolitis Obliterans ◽  
Lung Clearance ◽  
Lung Clearance Index ◽  
Minute Walk

Natural Variability of Clinically Measured Lung Clearance Index in Children with Cystic Fibrosis

2021 ◽  
Author(s):  
Bettina Sarah Frauchiger ◽  
Kathryn Ramsey ◽  
Jakob Usemann ◽  
Elisabeth Kieninger ◽  
Carmen Casaulta ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Natural Variability ◽  
Lung Clearance ◽  
Lung Clearance Index

Lung Clearance Index (LCI) in Patients with Bronchiolitis Obliterans: A Preliminary Report and Comparison to Cystic Fibrosis Patients

Lung ◽  
2016 ◽  
Vol 194 (6) ◽  
pp. 1007-1013 ◽  
Author(s):  
Michal Gur ◽  
Karin Yaacoby-Bianu ◽  
Anat Ilivitzki ◽  
Ronen Bar-Yoseph ◽  
Vered Nir ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Bronchiolitis Obliterans ◽  
Preliminary Report ◽  
Lung Clearance ◽  
Lung Clearance Index
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