Cerebral blood flow sensitivity to CO2 measured with steady-state and Read's rebreathing methods

2003 ◽  
Vol 137 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Jaideep J Pandit ◽  
Ravi M Mohan ◽  
Nicole D Paterson ◽  
Marc J Poulin
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Steady State ◽  
Flow Sensitivity ◽  
Rebreathing Methods

Cerebral blood flow sensitivities to CO2 measured with steady-state and modified rebreathing methods

2007 ◽  
Vol 159 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Jaideep J. Pandit ◽  
Ravi M. Mohan ◽  
Nicole D. Paterson ◽  
Marc J. Poulin
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Steady State ◽  
Rebreathing Methods

Quantitation of Regional Cerebral Blood Flow Increases during Motor Activation: A Steady-State Arterial Spin Tagging Study

NeuroImage ◽  
1997 ◽  
Vol 6 (2) ◽  
pp. 104-112 ◽  
Author(s):  
Frank Q. Ye ◽  
Anne M. Smith ◽  
Yihong Yang ◽  
Jeff Duyn ◽  
Venkata S. Mattay ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Steady State ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Motor Activation ◽  
Spin Tagging

scholarly journals Linearization Correction of 99mTc-Labeled Hexamethyl-Propylene Amine Oxime (HM-PAO) Image in Terms of Regional CBF Distribution: Comparison to C15O2 Inhalation Steady-State Method Measured by Positron Emission Tomography

1988 ◽  
Vol 8 (1_suppl) ◽  
pp. S52-S60 ◽  
Author(s):  
Atsushi Inugami ◽  
Iwao Kanno ◽  
Kazuo Uemura ◽  
Fumio Shishido ◽  
Matsutaro Murakami ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Steady State ◽  
Emission Tomography ◽  
Emission Computed Tomography ◽  
Whole Brain ◽  
Steady State Method ◽  
Positron Emission ◽  
State Method

The radioisotope distribution following intravenous injection of 99mTc-labeled hexamethylpropyleneamine oxime (HM-PAO) in the brain was measured by single photon emission computed tomography (SPECT) and corrected for the nonlinearity caused by differences in net extraction. The “linearization” correction was based on a three compartment model, and it required a region of reference to normalize the SPECT image in terms of regional cerebral blood flow distribution. Two different regions of reference, the cerebellum and the whole brain, were tested. The uncorrected and corrected HM-PAO images were compared with cerebral blood flow (CBF) image measured by the C15O2 inhalation steady state method and positron emission tomography (PET). The relationship between uncorrected HM-PAO and PET–CBF showed a correlation coefficient of 0.85 but tended to saturate at high CBF values, whereas it was improved to 0.93 after the “linearization” correction. The whole-brain normalization worked just as well as normalization using the cerebellum. This study constitutes a validation of the “linearization” correction and it suggests that after linearization the HM-PAO image may be scaled to absolute CBF by employing a global hemispheric CBF value as measured by the nontomographic 133Xe clearance method.

scholarly journals Changes in Cerebral Blood Flow during Steady-State Cycling Exercise: A Study Using Oxygen-15-Labeled Water with PET

2013 ◽  
Vol 34 (3) ◽  
pp. 389-396 ◽  
Author(s):  
Mikio Hiura ◽  
Tadashi Nariai ◽  
Kenji Ishii ◽  
Muneyuki Sakata ◽  
Keiichi Oda ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Steady State ◽  
Human Subjects ◽  
Insular Cortex ◽  
Cardiovascular Responses ◽  
Healthy Human ◽  
Cycling Exercise ◽  
Positron Emission ◽  
Steady State Cycling

Cerebral blood flow (CBF) during dynamic exercise has never been examined quantitatively using positron emission tomography (PET). This study investigated changes in CBF that occur over the course of a moderate, steady-state cycling exercise. Global and regional CBF (gCBF and rCBF, respectively) were measured using oxygen-15-labeled water (H215O) and PET in 10 healthy human subjects at rest (Rest), at the onset of exercise (Ex1) and at a later phase in the exercise (Ex2). At Ex1, gCBF was significantly ( P<0.01) higher (27.9%) than at Rest, and rCBF was significantly higher than at Rest in the sensorimotor cortex for the bilateral legs (M1Leg and S1Leg), supplementary motor area (SMA), cerebellar vermis, cerebellar hemispheres, and left insular cortex, with relative increases ranging from 37.6% to 70.5%. At Ex2, gCBF did not differ from Rest, and rCBF was significantly higher (25.9% to 39.7%) than at Rest in only the M1Leg, S1Leg, and vermis. The areas showing increased rCBF at Ex1 were consistent with the central command network and the anatomic pathway for interoceptive stimuli. Our results suggest that CBF increases at Ex1 in parallel with cardiovascular responses then recovers to the resting level as the steady-state exercise continues.

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