242 THE FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITOR PD0173074 AS A POTENTIAL NOVEL ANTI-PROSTATE CANCER THERAPY

2007 ◽  
Vol 6 (2) ◽  
pp. 83
Author(s):  
M. Goldstraw ◽  
M. Seckl ◽  
T. Christmas
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Therapy ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Prostate Cancer Therapy ◽  
Receptor Inhibitor

Fibroblast Growth Factor Receptor Inhibitor–Associated Multifocal Serous Retinal Detachments: A Case Report

2021 ◽  
pp. 247412642110136
Author(s):  
Diana H. Kim ◽  
Tian Xia ◽  
Peter Bracha ◽  
Brian L. VanderBeek
Keyword(s):  
Case Report ◽  
Growth Factor ◽  
Urothelial Carcinoma ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Metastatic Urothelial Carcinoma ◽  
Optical Coherence Tomography Imaging ◽  
Receptor Inhibitor

Purpose: This report aims to describe a case of bilateral, multifocal neurosensory retinal detachments that developed during erdafitinib therapy for metastatic urothelial carcinoma. Methods: A case report with color fundus imaging and spectral-domain optical coherence tomography imaging is presented. Results: A 50-year-old man with metastatic urothelial carcinoma had an unremarkable baseline ophthalmic examination prior to starting erdafitinib. At 3-month follow up, an examination revealed bilateral, multifocal retinal detachments. Because the patient was asymptomatic and erdafitinib was the only drug to which his tumor had responded, he was kept on the medication with close ophthalmic monitoring. Conclusions: Erdafitinib, a fibroblast growth factor receptor inhibitor, can cause bilateral, multifocal retinal detachments. Continuation of erdafitinib may be considered in patients without significant visual impairment when the overall benefit of the medication appears to outweigh the risks.

Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy

2011 ◽  
Vol 15 (7) ◽  
pp. 829-846 ◽  
Author(s):  
Christine Heinzle ◽  
Hedwig Sutterlüty ◽  
Michael Grusch ◽  
Bettina Grasl-Kraupp ◽  
Walter Berger ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Therapy ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

Abstract 1871: Alpha and beta isoforms of fibroblast growth factor receptor 1 in prostate cancer

2016 ◽  
Author(s):  
Estefania Labanca ◽  
Xinhai Wan ◽  
Jun Yang ◽  
Matthew Iyer ◽  
Christopher Logothetis ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth
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