233 Transurethral resection of prostate (TURP) with rectal balloon: New technique to control postoperative blood loss (preliminary results)

Abstract Background Perioperative bleeding is the most common complication related to transurethral resection of prostate; the aim of the study was to compare the effect of pre-operative use of finasteride versus cyproterone acetate (CPA) on blood loss with monopolar TURP. Methods This prospective randomized controlled study was conducted on (60) patients with BPH underwent monopolar TURP between July 2019 and July 2020. Patients were distributed into three equal groups; CPA group: 20 patients received cyproterone acetate 50 mg tab BID for two weeks before TURP, finasteride group: 20 patients received single daily dose of finasteride 5 mg for two weeks before TURP, control group: 20 patients received no treatment before TURP, all patients underwent monopolar TURP, and then histopathological examination of the resected tissues was done with assessment of the microvascular density of the prostate. Results Our study showed that there was significant decrease in intraoperative blood loss and operative time in CPA and finasteride groups in comparison with control group (p = 0.0012) (p < 0.0001), respectively, significant decrease in post-operative Hb and HCT value in finasteride and control groups in comparison with CPA group (p < 0.01), significant increase in specimen weight in CPA group compared to other groups (p < 0.01), and there was also significant decrease in microvascular density in CPA group in comparison with other groups (p < 0.01). Conclusion Cyproterone acetate is more effective than finasteride in decreasing perioperative bleeding with TURP by decreasing microvascular density of the prostate.

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848Efficacy of finasteride on blood loss after transurethral resection of prostate: A randomized placebo controlled clinical trial

European Urology Supplements ◽

10.1016/s1569-9056(05)80852-8 ◽

2005 ◽

Vol 4 (3) ◽

pp. 214

Author(s):

M. Salehi ◽

M. Fouladi Mehr ◽

S. Falahatkar ◽

A. Roshani

Keyword(s):

Clinical Trial ◽

Blood Loss ◽

Transurethral Resection ◽

Controlled Clinical Trial ◽

Transurethral Resection Of Prostate

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Transurethral Resection of Prostate and Bleeding: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial to See the Efficacy of Short-Term Use of Finasteride and Dutasteride on Operative Blood Loss and Prostatic Microvessel Density

Journal of Endourology ◽

10.1089/end.2016.0696 ◽

2017 ◽

Vol 31 (9) ◽

pp. 910-917 ◽

Cited By ~ 2

Author(s):

Ankur Bansal ◽

Aditi Arora

Keyword(s):

Blood Loss ◽

Transurethral Resection ◽

Microvessel Density ◽

Controlled Trial ◽

Transurethral Resection Of Prostate ◽

Operative Blood Loss ◽

Short Term ◽

Double Blind ◽

Double Blind Placebo

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ESTIMATION OF BLOOD LOSS AND FACTORS INFLUENCING BLOOD LOSS IN TRANSURETHRAL RESECTION OF PROSTATE: A PROSPECTIVE STUDY

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2016/1717 ◽

2016 ◽

Vol 5 (103) ◽

pp. 7592-7598

Author(s):

Vetrichandar S ◽

Aysha Shaheen B

Keyword(s):

Blood Loss ◽

Prospective Study ◽

Transurethral Resection ◽

Transurethral Resection Of Prostate ◽

Factors Influencing ◽

A Prospective Study

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The effect of preoperative finasteride therapy on perioperative blood loss in transurethral resection of Prostate for patients with benign prostatic hyperplasia

International Journal of Surgery Science ◽

10.33545/surgery.2020.v4.i1d.339 ◽

2020 ◽

Vol 4 (1) ◽

pp. 215-218

Author(s):

Preetam Penumatcha ◽

Krishna Rao SV ◽

Rambabu DVS

Keyword(s):

Benign Prostatic Hyperplasia ◽

Blood Loss ◽

Transurethral Resection ◽

Prostatic Hyperplasia ◽

Transurethral Resection Of Prostate ◽

Perioperative Blood Loss

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Single Intravenous Bolus versus Continuous Infusion of Tranexamic Acid to Reduce Blood Loss in Transurethral Resection of Prostate: a Prospective Randomized Double-Blind Study

QJM ◽

10.1093/qjmed/hcab086.026 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Safaa I Ghaly ◽

Marwa A Khairy ◽

Mohamed M Kamal ◽

Eman A Mohammed

Keyword(s):

Blood Loss ◽

Tranexamic Acid ◽

Transurethral Resection ◽

Bolus Dose ◽

Transurethral Resection Of Prostate ◽

Intraoperative Blood Loss ◽

Operative Blood Loss ◽

Single Bolus Dose ◽

Group A ◽

Group B

Abstract Background and aim Intraoperative use of a single bolus dose of tranexamic acid may not be sufficient to prevent bleeding in the early postoperative period. The present study was carried out to compare the effect of two dose regimens of tranexamic acid in reducing perioperative blood loss and the amount of allogeneic blood transfusion in transurethral resection of prostate. Design prospective, double-blinded and controlled study. Setting Ain Shams University Hospital, Patients and Methods 50 patients electively posted for transurethral resection of prostate were randomly assigned to receive a single bolus dose of tranexamic acid (10 mg/kg) (Group A), a bolus dose of tranexamic acid (10 mg/kg) followed by infusion (1 mg/kg/h) till 4 h postoperatively (Group B). Measurements Total intraoperative blood loss, amount of allogeneic blood transfusion, postoperative drain collections, and hemoglobin and hematocrit levels were recorded at different time intervals. Data obtained after comparing two groups were analyzed using the statistical package for social sciences. Results There was no statistically significant difference among patients in both groups regarding intraoperative blood loss and postoperative blood loss at 6 hrs and 48 hrs postoperatively. However the post-operative blood loss at 24 hrs was significantly higher among patients in group A than patients in group B (P-value= 0.014) . Conclusion Tranexamic acid causes more effective reduction in post-operative blood loss when used as a bolus followed by an infusion continued in the postoperative period in comparison to its use as a single intravenous bolus in transurethral resection of prostate.

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