427 Plasma and urinary pharmacokinetics of the novel, oral SHIP1 activator, AQX-1125 in interstitial cystitis/bladder pain syndrome (IC/BPS): Results of the phase2 LEADERSHIP trial

C. Nickel; R. Evans; P. Tam; J. Toews; L. MacKenzie; H. Biagi; S. Shrewsbury

doi:10.1016/s1569-9056(16)60429-3

427 Plasma and urinary pharmacokinetics of the novel, oral SHIP1 activator, AQX-1125 in interstitial cystitis/bladder pain syndrome (IC/BPS): Results of the phase2 LEADERSHIP trial

European Urology Supplements ◽

10.1016/s1569-9056(16)60429-3 ◽

2016 ◽

Vol 15 (3) ◽

pp. e427

Author(s):

C. Nickel ◽

R. Evans ◽

P. Tam ◽

J. Toews ◽

L. MacKenzie ◽

...

Keyword(s):

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

The Novel ◽

Bladder Pain

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Intravesical treatment of bladder pain syndrome/interstitial cystitis: from the conventional regimens to the novel botulinum toxin injections

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.2014.909406 ◽

2014 ◽

Vol 23 (6) ◽

pp. 751-757 ◽

Cited By ~ 12

Author(s):

Athanasios Dellis ◽

Athanasios G Papatsoris

Keyword(s):

Botulinum Toxin ◽

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

The Novel ◽

Bladder Pain ◽

Intravesical Treatment ◽

Botulinum Toxin Injections

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A Phase II Study of the Efficacy and Safety of the Novel Oral SHIP1 Activator AQX-1125 in Subjects with Moderate to Severe Interstitial Cystitis/Bladder Pain Syndrome

The Journal of Urology ◽

10.1016/j.juro.2016.03.003 ◽

2016 ◽

Vol 196 (3) ◽

pp. 747-754 ◽

Cited By ~ 22

Author(s):

J. Curtis Nickel ◽

Blair Egerdie ◽

Edward Davis ◽

Robert Evans ◽

Lloyd Mackenzie ◽

...

Keyword(s):

Interstitial Cystitis ◽

Phase Ii ◽

Phase Ii Study ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

The Novel ◽

Efficacy And Safety ◽

Bladder Pain

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Faculty of 1000 evaluation for A Randomized, Double-Blind, Placebo Controlled Trial of Adalimumab in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718022125.793480106 ◽

2013 ◽

Author(s):

Altaf Mangera

Keyword(s):

Interstitial Cystitis ◽

Controlled Trial ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Double Blind ◽

Bladder Pain ◽

Double Blind Placebo

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Faculty Opinions recommendation of Histopathological characteristics of interstitial cystitis/bladder pain syndrome without Hunner lesion.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727495177.793552386 ◽

2018 ◽

Author(s):

Pradeep Tyagi

Keyword(s):

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Bladder Pain

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Faculty Opinions recommendation of Histological evidence supports low anesthetic bladder capacity as a marker of a bladder-centric disease subtype in interstitial cystitis/bladder pain syndrome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736074892.793562083 ◽

2019 ◽

Author(s):

Pradeep Tyagi

Keyword(s):

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Capacity ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Histological Evidence ◽

Disease Subtype

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Interstitial cystitis, bladder pain syndrome, hypersensitive bladder, and interstitial cystitis/bladder pain syndrome – clarification of definitions and relationships

International Journal of Urology ◽

10.1111/iju.13970 ◽

2019 ◽

Vol 26 (S1) ◽

pp. 20-24 ◽

Cited By ~ 3

Author(s):

Yukio Homma

Keyword(s):

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Bladder Pain

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Voiding Dysfunctions in Patients with Non‐Hunner’s Ulcer Interstitial Cystitis/ Bladder Pain Syndrome Do Not Affect Long‐term Treatment Outcome

International Journal of Clinical Practice ◽

10.1111/ijcp.14372 ◽

2021 ◽

Author(s):

Wan‐Ru Yu ◽

Wei‐Chuan Chang ◽

Hann‐Chorng Kuo

Keyword(s):

Treatment Outcome ◽

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Term Treatment ◽

Bladder Pain ◽

Long Term Treatment ◽

Voiding Dysfunctions

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Commentary: Efficacy of Clorpactin in refractory bladder pain syndrome/interstitial cystitis: a randomized controlled trial

International Urogynecology Journal ◽

10.1007/s00192-021-04731-z ◽

2021 ◽

Author(s):

Mittal Patel

Keyword(s):

Randomized Controlled Trial ◽

Interstitial Cystitis ◽

Controlled Trial ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Randomized Controlled

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Hydrodistention does not alter bladder gene expression profiles in patients with non‐Hunner lesion interstitial cystitis/bladder pain syndrome

Neurourology and Urodynamics ◽

10.1002/nau.24680 ◽

2021 ◽

Author(s):

Raymond Xu ◽

Jeffrey Schachar ◽

Robert J. Evans ◽

Catherine A. Matthews ◽

Gopal Badlani ◽

...

Keyword(s):

Gene Expression ◽

Interstitial Cystitis ◽

Expression Profiles ◽

Gene Expression Profiles ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Bladder Pain

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Editorial Comment from Dr Ueda to Decreased urothelial cytoskeleton and cell proliferation protein expression suggest interstitial cystitis/bladder pain syndrome patients with Hunner’s lesion and grade 3 glomerulation might be different from other types of patients

International Journal of Urology ◽

10.1111/iju.14621 ◽

2021 ◽

Author(s):

Tomohiro Ueda

Keyword(s):

Cell Proliferation ◽

Editorial Comment ◽

Protein Expression ◽

Interstitial Cystitis ◽

Pain Syndrome ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Grade 3

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