Chronic Allograft Dysfunction – An Analysis

2008 ◽  
Vol 2 ◽  
pp. 49-50
Author(s):  
R. Dilip ◽  
K.G. Arun ◽  
A Chandrasekhar ◽  
P. Girish ◽  
Vakrani ◽  
...  
Keyword(s):  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction

Upper Lobe Fibrosis: A Novel Manifestation of Chronic Allograft Dysfunction in Lung Transplantation

2005 ◽  
Vol 24 (9) ◽  
pp. 1260-1268 ◽  
Author(s):  
Smita Sakha Pakhale ◽  
Denis Hadjiliadis ◽  
David N. Howell ◽  
Scott M. Palmer ◽  
Carlos Gutierrez ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction

scholarly journals Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction

2012 ◽  
Vol 28 (2) ◽  
pp. 327-336 ◽  
Author(s):  
H. T. Ko ◽  
J. L. Yin ◽  
K. Wyburn ◽  
H. Wu ◽  
J. M. Eris ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction

scholarly journals Underlying Causes and Risk Factors of Chronic Renal Allograft Dysfunction Among Renal Transplant Recipients

Acta Medica ◽  
2021 ◽  
pp. 1-10
Author(s):  
Göksel Güven ◽  
Şeref Rahmi Yılmaz ◽  
Tolga Yıldırım ◽  
Fazıl Tuncay Akı ◽  
Yunus Erdem
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Chronic Allograft Dysfunction ◽  
Specific Antibodies ◽  
Panel Reactive Antibody ◽  
Allograft Dysfunction ◽  
Donor Specific Antibodies ◽  
Reactive Antibody

Objective: Dialysis or renal transplantation are the two treatment options for end-stage renal disease patients. Renal transplantation from an appropriate donor increases survival and quality of life compared to treatment with dialysis. Recent advances in immunosuppressive therapy have significantly improved the success in 1-year graft survival. However, the long-term graft survival remains the same. Therefore, we aimed to determine the underlying causes and risk factors of chronic allograft dysfunction in renal transplant recipients. Materials and Methods: From 2000 to 2012, all consecutive renal transplant recipients followed in our tertiary referral center who underwent renal biopsy due to an increase in serum creatinine level were enrolled. Etiologies of chronic allograft dysfunction were assessed according to pathologic results of renal biopsy specimens and laboratory findings. The immunological and non-immunological risk factors of chronic allograft dysfunction were screened and recorded retrospectively. Results: Eighty (80) renal transplant recipients with a mean age of 38±10 years were included in the study. Delayed graft function (p=0.007), history of acute rejection (p<0.001), positive panel reactive antibody (p=0.033) (Class I (p=0.013), Class II (p=0.006)), positive donor specific antibodies (p=0.001), number of recurrent acute rejections (p<0.001), number of human leukocyte antigens mismatches (p=0.051), cold ischemia time (p=0.001) were found to be risk factors for chronic allograft dysfunction. The donor specific antibodies positivity (p<0.001) and the panel reactive antibody positivity (Class I (p=0.003), Class II (p=0.001)) were significantly higher in patients with antibody mediated rejection than patients without antibody mediated rejection (p=0.002). Conclusion: Delayed graft function, presence and the number of acute rejections, increased cold ischemia time, panel reactive antibody positivity, donor specific antibodies positivity, and the number of human leukocyte antigens mismatches were risk factors for chronic allograft dysfunction.

scholarly journals Regulation of Endothelial-to-Mesenchymal Transition by MicroRNAs in Chronic Allograft Dysfunction

2019 ◽  
Vol 103 (4) ◽  
pp. e64-e73 ◽  
Author(s):  
Emily K. Glover ◽  
Nina Jordan ◽  
Neil S. Sheerin ◽  
Simi Ali
Keyword(s):  
Chronic Allograft Dysfunction ◽  
Mesenchymal Transition ◽  
Allograft Dysfunction ◽  
Endothelial To Mesenchymal Transition

scholarly journals Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients

2018 ◽  
Vol 32 (12) ◽  
pp. e13436 ◽  
Author(s):  
Jennifer F. Wu ◽  
Amutha Muthusamy ◽  
Gabriel A. Al-Ghalith ◽  
Dan Knights ◽  
Bin Guo ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction ◽  
Urinary Microbiome

scholarly journals Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation

2019 ◽  
Vol 20 (3) ◽  
pp. 825-833 ◽  
Author(s):  
Jamie L. Todd ◽  
Fran L. Kelly ◽  
Andrew Nagler ◽  
Kane Banner ◽  
Elizabeth N. Pavlisko ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Airway Remodeling ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction

scholarly journals Conversion to sirolimus for chronic allograft dysfunction: long-term results confirm predictive value of proteinuria

2007 ◽  
Vol 0 (0) ◽  
pp. 071115125226003-???
Author(s):  
Fritz Diekmann ◽  
Klemens Budde ◽  
Torsten Slowinski ◽  
Federico Oppenheimer ◽  
Lutz Fritsche ◽  
...  
Keyword(s):  
Predictive Value ◽  
Long Term Results ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction
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