Chronic allograft dysfunction: can we use mammalian target of rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?

2008 ◽  
Vol 13 (6) ◽  
pp. 614-621 ◽  
Author(s):  
Ravinder K Wali ◽  
Matthew R Weir
Keyword(s):  
Mammalian Target Of Rapamycin ◽  
Graft Function ◽  
Calcineurin Inhibitors ◽  
Target Of Rapamycin ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction

Mammalian Target of Rapamycin Inhibitors Vs Calcineurin Inhibitors in Chronic Graft Rejection After Lung Transplantation: A Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Andressa Rodrigues de Souza ◽  
Thulssa Auxiliadora Gomes Medeiros dos Santos ◽  
Camila Bomfim Von Jakitsch ◽  
Ana Lúcia Gargione Galvão de Sant'Anna ◽  
João Carlos Marchiori de Claudio ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Transplantation ◽  
Graft Rejection ◽  
Meta Analysis ◽  
Mammalian Target Of Rapamycin ◽  
Calcineurin Inhibitors ◽  
Target Of Rapamycin

Conversion of Calcineurin Inhibitors With Mammalian Target of Rapamycin Inhibitors After Kidney Transplant

2012 ◽  
Vol 11 (1) ◽  
pp. 12-16
Author(s):  
Hassan Nikoueinejad ◽  
◽  
Alireza Soleimani ◽  
Abbas Mirshafiey ◽  
Aliakbar Amirzargar ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Mammalian Target Of Rapamycin ◽  
Calcineurin Inhibitors ◽  
Target Of Rapamycin

scholarly journals Mammalian Target of Rapamycin Inhibitors Combined With Calcineurin Inhibitors as Initial Immunosuppression in Renal Transplantation

2019 ◽  
Vol 103 (10) ◽  
pp. 2031-2056 ◽  
Author(s):  
Nuria Montero ◽  
Maria Quero ◽  
Edoardo Melilli ◽  
María José Pérez-Sáez ◽  
Dolores Redondo-Pachón ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Mammalian Target Of Rapamycin ◽  
Calcineurin Inhibitors ◽  
Target Of Rapamycin

scholarly journals A novel biomarker of chronic allograft dysfunction in renal transplant recipients (serum calreticulin and CD47)

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Rasha Ibrahim Abdel Razek Gawish ◽  
Hayam Abdel Meguid El Aggan ◽  
Sabah Abdel Hady Mahmoud ◽  
Sara Ahmed Mohamed Mortada
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Interstitial Fibrosis ◽  
Graft Function ◽  
High Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Renal Transplant Recipients ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction ◽  
Potential Biomarker

Abstract Background Chronic allograft dysfunction (CAD) is considered the leading cause of late allograft loss. The cluster of differentiation 47 (CD47) and calreticulin (CRT) are involved in many and diverse cellular processes. The present study was designed to study the role of the pro-phagocytic CRT and anti-phagocytic CD47 signals in patients with renal transplantation in relation to graft function. Thirty renal transplantation recipients (RTR) for more than 6 months [15 with stable renal function and 15 with chronic allograft dysfunction (CAD)] and 15 healthy controls were enrolled in the study. Quantification of CRT, CD47, and high-sensitivity C-reactive protein (hsCRP) levels in serum was done using standardized enzyme-linked immunosorbent assay (ELISA) kits. Measurement of renal function and urinary alkaline phosphatase (U.ALP) was done. Renal interstitial fibrosis (IF) was graded in renal biopsies of CAD. Results Serum CRT and urinary ALP levels were statistically significant higher (P < 0.001) while serum CD47 level was statistically significant lower (P < 0.001) in patients with CAD than patients with stable graft function and controls. There was statistically insignificant difference between controls and patients with stable graft function. Serum CRT and serum CD47 levels were positively correlated with each other and with worsening renal and tubular function, serum hsCRP in RTR and with degree of renal IF in patients with CAD (P < 0.05). Conclusions The activation and dysregulation of CRT and CD47 could play a role in the development of CAD and could be a potential biomarker for renal allograft dysfunction.

scholarly journals Conversion from calcineurin inhibitors to sirolimus in chronic allograft dysfunction: changes in glomerular haemodynamics and proteinuria

2005 ◽  
Vol 21 (2) ◽  
pp. 488-493 ◽  
Author(s):  
Anna Saurina ◽  
Josep M. Campistol ◽  
Carlos Piera ◽  
Fritz Diekmann ◽  
Begoña Campos ◽  
...  
Keyword(s):  
Calcineurin Inhibitors ◽  
Chronic Allograft Dysfunction ◽  
Allograft Dysfunction
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