scholarly journals Phase I Study De-Intensifying Exposure of Post-Transplantation Cyclophosphamide (PTCy) after HLA-Haploidentical Hematopoietic Cell Transplantation (HCT) for Hematologic Malignancies

2021 ◽  
Vol 27 (3) ◽  
pp. S9-S11
Author(s):  
Meredith J. McAdams ◽  
Dimana Dimitrova ◽  
Jennifer L. Sadler ◽  
Seth M. Steinberg ◽  
Jennifer Cuellar-Rodriguez ◽  
...  
Keyword(s):  
Phase I ◽  
Cell Transplantation ◽  
Phase I Study ◽  
Hematopoietic Cell Transplantation ◽  
Hematologic Malignancies ◽  
Hematopoietic Cell ◽  
Post Transplantation ◽  
Haploidentical Hematopoietic Cell Transplantation

scholarly journals Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation

2021 ◽  
Vol 12 ◽  
Author(s):  
Richard J. Lin ◽  
Harold K. Elias ◽  
Marcel R. M. van den Brink
Keyword(s):  
Cell Transplantation ◽  
Older Patients ◽  
Immune Reconstitution ◽  
Hematopoietic Cell Transplantation ◽  
Hematologic Malignancies ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Post Transplantation ◽  
Independent Manner ◽  
Hematopoietic Stem

Older patients with hematologic malignancies are increasingly considered for allogeneic hematopoietic cell transplantation with encouraging outcomes. While aging-related thymic dysfunction remains a major obstacle to optimal and timely immune reconstitution post- transplantation, recent accumulating evidence has suggested that various aging hallmarks such as cellular senescence, inflamm-aging, and hematopoietic stem cell exhaustion, could also impact immune reconstitution post-transplantation in both thymic-dependent and independent manner. Here we review molecular and cellular aspects of immune senescence and immune rejuvenation related to allogeneic hematopoietic cell transplantation among older patients and discuss potential strategies for mechanism-based therapeutic intervention.

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