Clear cell carcinoma arising in pleomorphic adenoma of the minor salivary gland

AbstractMalignant change arising in pleomorphic adenoma of the salivary glands is uncommon, with a reported incidence of 2–10 per cent.Only one case where a pleomorphic adenoma became a clear cell carcinoma appears to have been published in the English literature. An additional case of clear cell carcinoma arising in pleomorphic adenoma of a minor salivary gland is reported and the relevant literature discussed.

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Clear Cell Carcinoma Arising from Pleomorphic Adenoma of a Minor Salivary Gland

Acta Cytologica ◽

10.1159/000326043 ◽

2006 ◽

Vol 50 (6) ◽

pp. 687-690 ◽

Cited By ~ 7

Author(s):

Shahrzad Negahban ◽

Yahya Daneshbod ◽

Mahmood Shishegar

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Pleomorphic Adenoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Gland ◽

A Minor

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Hyalinizing clear cell carcinoma of the nasopharynx operated by trans-oral and trans-palatal approach

The Journal of Laryngology & Otology ◽

10.1017/s0022215114002485 ◽

2015 ◽

Vol 129 (S2) ◽

pp. S95-S97 ◽

Cited By ~ 2

Author(s):

T Nakashima ◽

R Yasumatsu ◽

M Yamauchi ◽

S Toh ◽

T Nakano ◽

...

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Surgical Resection ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Gland ◽

Good Prognosis ◽

Salivary Gland Neoplasm ◽

Hyalinizing Clear Cell Carcinoma

AbstractBackground:Hyalinizing clear cell carcinoma is a rare minor salivary gland neoplasm. The treatment of choice is surgical resection with or without post-operative radiotherapy. This tumour often demonstrates a good prognosis.Case report:We report a case of hyalinizing clear cell carcinoma arising in the nasopharynx. A 27-year-old female presented with progressive hearing disturbance and tinnitus. On examination, an expansile mass was observed in her nasopharynx. Biopsy was performed and the pathology results returned as clear cell carcinoma.Results and conclusion:Surgical resection was performed trans-orally accompanied by trans-palatal approach. She has no recurrence during more than two years of follow up.

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The role of immunohistochemistry in the diagnosis of hyalinizing clear cell carcinoma of the minor salivary gland: a case report

European Journal of Histochemistry ◽

10.4081/1224 ◽

2009 ◽

Vol 52 (4) ◽

pp. 251 ◽

Cited By ~ 20

Author(s):

G Lai ◽

S Nemolato ◽

S Lecca ◽

G Parodo ◽

C Medda ◽

...

Keyword(s):

Salivary Gland ◽

Case Report ◽

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Gland ◽

Hyalinizing Clear Cell Carcinoma

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Patterns of Care and Outcome of Clear Cell Carcinoma of the Head and Neck

Otolaryngology ◽

10.1177/0194599819835779 ◽

2019 ◽

Vol 161 (1) ◽

pp. 98-104 ◽

Cited By ~ 4

Author(s):

Jamie Oliver ◽

Peter Wu ◽

Clifford Chang ◽

Dylan Roden ◽

Binhuan Wang ◽

...

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Head And Neck ◽

Salivary Glands ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Tumor Grade ◽

Low Grade ◽

Major Salivary Gland ◽

Positive Margins

Objective Clear cell carcinoma (CCC) is a rare salivary gland malignancy, believed to be generally low grade. We investigated CCC epidemiology and clinical behavior, using the National Cancer Database (NCDB). Study Design Retrospective cohort study. Setting NCDB. Subjects and Methods All CCCs of the salivary glands were selected between 2004 and 2015. Patient demographics, tumor characteristics, treatments, and survival were analyzed. Cox regression analyses were performed in treated patients. Results We identified 268 patients with CCC. Median age was 61 (21-90) years. Most were female (145, 54%). The most common site was oral cavity (119, 44%), followed by major salivary glands (68, 25%) and oropharynx (41, 15%). Most tumors were low grade (81, 68%) and stages I to II (117, 60.6%). Nodal (36, 17.5%) and distant metastases (6, 2.4%) were rare. Most were treated by surgery alone (134, 50.0%), followed by surgery and radiotherapy (69, 25.7%). Five-year overall survival (OS) was 77.6% (95% CI, 71.4%-84.2%). In univariate analysis, older age, major salivary gland and sinonasal site, stages III to IV, high grade, and positive margins were associated with worse OS. In multivariate analysis, only high tumor grade (hazard ratio [HR], 5.76; 95% CI, 1.39-23.85; P = .02), positive margins (HR, 4.01; 95% CI, 1.20-13.43; P = .02), and age ≥60 years (HR, 3.45; 95% CI, 1.39-8.55; P = .01) were significantly associated with OS. Conclusion We report the largest series of clear cell carcinomas of the head and neck. Outcomes are generally favorable following surgical-based treatments. In this series, pathologic tumor grade is associated with worse survival. Routine evaluation and reporting of tumor grade might better guide physicians in recommending appropriate treatments in this rare malignancy.

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Clear cell carcinoma of the minor salivary gland: an autopsy case with multiple metastases 29 years after the initial surgery and a review of the literature

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/j.tripleo.2009.01.034 ◽

2009 ◽

Vol 107 (6) ◽

pp. 819-825 ◽

Cited By ~ 11

Author(s):

Kyoko Yamashita ◽

Fumi Kawakami ◽

Yasuaki Nakashima ◽

KenIchiro Murakami

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Gland ◽

Autopsy Case ◽

Review Of The Literature ◽

Initial Surgery ◽

Multiple Metastases

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Clear Cell Carcinoma of Palatal Minor Salivary Gland Harboring a Novel EWSR1-ATF1 Fusion Gene: Report of a Case and Review of the Literature

Head and Neck Pathology ◽

10.1007/s12105-020-01211-6 ◽

2020 ◽

Author(s):

Katsutoshi Hirose ◽

Yu Usami ◽

Masaharu Kohara ◽

Sunao Sato ◽

Yuri Iwamoto ◽

...

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Clear Cell ◽

Fusion Gene ◽

Clear Cell Carcinoma ◽

Minor Salivary Gland ◽

Review Of The Literature

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Glycogen-rich clear cell carcinoma in the tongue

The Journal of Laryngology & Otology ◽

10.1017/s0022215100127938 ◽

1994 ◽

Vol 108 (8) ◽

pp. 716-718 ◽

Cited By ~ 17

Author(s):

Esa Rajab ◽

Sharifah Nor Akmal ◽

Abdul Majid Nasir

Keyword(s):

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Gland ◽

Needle Aspiration ◽

Nodal Metastasis ◽

Needle Aspiration Cytology ◽

Minor Salivary Gland Tumour ◽

A Minor ◽

Gland Tumour

AbstractThe case of a minor salivary gland tumour, arising from the tongue, with nodal metastasis is presented. Biopsy of the tumour and fine-needle aspiration cytology of the neck swelling showed the presence of a clear cell carcinoma with evidence of nodal metastases. A commando operation was performed and the defect was reconstructed using a local tongue flap. The literature review indicated that the neoplasm was rare and its site of occurrence rather unusual.

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