Metastatic salivary pleomorphic adenoma

1990 ◽  
Vol 104 (1) ◽  
pp. 45-47 ◽  
Author(s):  
David W. Sim ◽  
Arnold G. D. Maran ◽  
Douglas Harris
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Pulmonary Metastasis ◽  
Pleomorphic Adenomas ◽  
Benign Tumours ◽  
The Right

AbstractPleomorphic adenomas of the salivary gland are usually regarded as benign tumours. We report a case in which a solitary pulmonary metastasis arose from a pleomorphic adenoma of the right parotid gland. The mechanism of metastasis is discussed.

Heterotopic pleomorphic adenoma of the external nose

1996 ◽  
Vol 110 (4) ◽  
pp. 376-378 ◽  
Author(s):  
Lydia Badia ◽  
Justin N. Weir ◽  
Anthony C. Robinson
Keyword(s):  
Salivary Gland ◽  
Nasal Cavity ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Subcutaneous Tissue ◽  
Minor Salivary Glands ◽  
Salivary Gland Tumours ◽  
External Nose ◽  
Pleomorphic Adenomas ◽  
The Right

AbstractPleomorphic adenomas arising from sites other than the major or minor salivary glands are uncommon. We describe a case of pleomorphic adenoma in the subcutaneous tissue of the nasomaxillary crease. An identical tumour was previously excised from the right nasal cavity. The possible aetiology of these heterotopic salivary gland tumours is discussed.

scholarly journals Etiology and familial inheritance of pleomorphic adenomas

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Krysten Clark
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
White Male ◽  
Salivary Gland Tumor ◽  
Major Salivary Gland ◽  
Gland Tumor ◽  
Superficial Lobe ◽  
Increased Risk ◽  
Pleomorphic Adenomas

Background: A pleomorphic adenoma is the most common salivary gland neoplasm in both children and adults. Pleomorphic adenomas are derived from ductal and myoepithelial cells and are most commonly found in the superficial lobe of the parotid gland. The purpose of this article is to discuss the genes involved in pleomorphic adenomas and the possible autosomal dominant mode of inheritance. Case Description: The first patient was a white male who was diagnosed with carcinoma ex pleomorphic adenoma, a highly aggressive tumor, at the age of 57. He had an undiagnosed pleomorphic adenoma for approximately 15 years prior. The tumor was excised and the patient underwent radiation in the location of his parotid gland for 4 years until he deceased. The second patient is a white female, his daughter, who was diagnosed with a benign pleomorphic adenoma at the age of 46. Her salivary gland tumor was excised and normal follow up appointments occurred. Practical Implications: Pleomorphic adenomas most commonly affect the parotid gland, the largest of the three major salivary gland tumors. Occurrence and excision of this salivary gland tumor will cause a decrease in the secretion of saliva, leading to a dry mouth and an increased risk of caries.

scholarly journals SALIVARY GLAND TUMOURS;

2017 ◽  
Vol 24 (09) ◽  
pp. 1327-1330
Author(s):  
Arifullah - ◽  
Irfan Ul Islam Nasir ◽  
Syed Zafar Hassan ◽  
Ghulam Muhammad
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumours ◽  
Surgical Department ◽  
Adenoid Cystic ◽  
Pleomorphic Adenomas ◽  
Warthin’S Tumour ◽  
Benign Tumours ◽  
Common Benign Tumour

Objectives: The objective of the study was to find the frequency of salivarygland tumours. Study Design: A descriptive study. Period: 1st Jan 2008 to 31st Dec 2010 (of 3years duration). Setting: ENT department Khyber Teaching Hospital and Surgical departmentHayatabad Medical Complex, Peshawar. Material and methods: Total number of 108 patientshaving salivary gland tumours enrolled from admitted patients in ENT department KhyberTeaching Hospital and Surgical department Hayatabad Medical Complex Peshawar. Thestudy was designed to find the frequency of salivary gland tumours. Results: In our studymost of the patients were having benign tumours (80.6%) with malignant counterpart in about19.4%. Overall the most common tumour was pleomorphic adenoma about 71.3% followed byMucoepidermoid 6.5%, adenoid cystic carcinoma 4.6% and Warthin’s tumour 4.6%. The mostcommonly involved salivary gland is parotid gland about 78.7% (85/108) with pleomorphicadenoma being the most common benign tumour and Mucoepidermoid the malignant variety.In submandibular gland/ sublingual glands the most common was pleomorphic adenomaand in minor salivary gland majority were malignant. Conclusion: Most of the salivary glandtumours are benign with majority of them are pleomorphic adenomas and parotid gland is themost common involved salivary gland.

scholarly journals USE OF 29A MICRO-RNA FOR DIAGNOSIS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS

2020 ◽  
Vol 20 (1) ◽  
pp. 149-154
Author(s):  
I. S. Brodetskyi ◽  
V.A. Malanchuk ◽  
V. E Dosenko
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Venous Blood ◽  
Micro Rna ◽  
Salivary Gland Tissue ◽  
Pleomorphic Adenomas ◽  
Gland Tissue ◽  
Benign Tumours

Introduction. Pleomorphic adenoma is known as the most common tumour in salivary glands that makes up 60-90% of all benign tumours of the salivary glands. The modern genetic tendency towards the diagnosis of salivary gland tumours is the study of the role of microRNA molecules, and miRNA-29a in the focus of the great researchers’ interest. It is expressed in 84 % of the pleomorphic adenomas of the salivary glands. Objectives. Determination of expression of miRNA-29a in tissues of pleomorphic adenomas of the large salivary glands that adjacent to the tumour of the tissue of the salivary gland, intact tissue of the salivary gland, was out of touch with the tumour and venous blood.  Materials and methods. The study included 20 patients with benign tumours of the large salivary glands (pleomorphic adenomas). The expression of miRNA-29a was evaluated by using reverse transcription and quantitative polymerase chain reaction (qPCR) in real time. Results. The analysis of the level of miRNA-29a expression revealed that among 4 groups of indicators (tumour tissue, tissues adjacent to the tumour salivary gland tissue, intact salivary gland, which was out of touch with the tumour and venous blood) in patients with pleomorphic adenoma of the large salivary gland, the highest expression was noted in the group, where salivary gland tissue was adjacent to the salivary gland tumour (111, 93±56, 97 versus 8,12±4,4). Correlation analysis of patients with pleomorphic adenoma of the large salivary glands with different fragments of tissues samples demonstrated that the expression level of miRNA-29a differed significantly between the groups (adjacent gland - intact salivary tissue). Conclusions. A sufficiently high level of miRNA-29a expression in the tissues of pleomorphic adenoma in the large salivary glands compared with the normal (intact salivary gland tissue), 10 times as much can be used as a genetic marker for verification (identification) of this type of tumours. Studies of biopsy material from patients with pleomorphic adenoma in the large salivary glands at the genetic level (by expression of miRNAs-29a) confirm the need not only in enucleating of the tumour (partial parotidectomy), but also in performing of subtotal resection with removal of salivary gland adjacent to the tumour.

The recurrence rate of pleomorphic adenoma in the long-term follow-up according to the clinic of maxillofacial surgery

2020 ◽  
pp. 16-20
Author(s):  
A.I. Yaremenko ◽  
S.I. Kutukova ◽  
G.G. Harutyunyan ◽  
N.L. Petrov
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Maxillofacial Surgery ◽  
Fibrous Capsule ◽  
Parotid Salivary Gland ◽  
Long Term Follow Up ◽  
Benign Tumours

In this study we sought to investigate the patients history database, underwent surgical treatment of removing pleomorphic adenoma amass form parotid gland (PG), also identifi replays of mass in the long-term follow-up period. Material and methods: 391 case histories of patients with benign tumours of the (PG) were analysed in detail. 200 (51,1%) patients had a morphological diagnosis of a pleomorphic adenoma (PA). During postoperative follow-up, 39 (n=39) patients were examined, During the ultrasound (sonography) examination were identify 7 patients with replays of neoplasm of parotid salivary gland (pleomorphic adenoma?), the average age of the patients at the time of the examination was 41.6±13.4 years (men — 42 years old, women — 48.8+11.8 years). The sex ratio of patients were 6 females and 1 male patient, the average time of relapse occurred in the long-term follow-up period was 8.3 years. The morphological study of prevues surgery of 7 patients with relapse of neoplasm of parotid salivary gland (pleomorphic adenoma ?), revealed a predominance of mixoid component in all patients, out of 5 patients with PA, the fibrous capsule had a complete structure, the capsule is partially or completely thinned in 1 patient, and in 1 patient is completely absent. Conclusion: By retrospective analysis of the data of patients who underwent to surgery of parotid gland surdested that the likelihood of tumor recurrence increases with the predominance of the myxold component in the structure of pleomorphic adenoma, especially in those where it is limited to the use of the method of ectracapsular enucleation, performed even in an extended version within the surface part of the parotid gland. In addition, the risk of recurrence increases with morphological signs of complete or partial absence of the fibrous capsule of the PA.

scholarly journals Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma

2021 ◽  
Author(s):  
Costantino Ricci ◽  
Federico Chiarucci ◽  
Francesca Ambrosi ◽  
Tiziana Balbi ◽  
Barbara Corti ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumors ◽  
Melanin Pigment ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Pertinent Literature

AbstractThe presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.

scholarly journals Giant Cell Carcinosarcoma of the Parotid Gland With a PLAG 1 Translocation in Association With a Pleomorphic Adenoma With HMGA2 Translocation

2020 ◽  
Vol 154 (6) ◽  
pp. 811-815
Author(s):  
Levon Katsakhyan ◽  
Virginia A LiVolsi ◽  
Ara A Chalian ◽  
Paul J Zhang
Keyword(s):  
Salivary Gland ◽  
In Situ Hybridization ◽  
Parotid Gland ◽  
Giant Cell ◽  
Pleomorphic Adenoma ◽  
De Novo ◽  
Sarcomatous Component ◽  
Gland Tumor ◽  
Parotid Gland Tumor

Abstract Objectives Carcinosarcomas of the salivary gland are rare neoplasms and have been described arising de novo or in association with pleomorphic adenoma (PA). PLAG1 and HMGA2 translocations are known to occur in PAs and carcinomas ex PA but are mutually exclusive. Methods We report a case of a carcinosarcoma in the parotid gland of a 77-year-old man with unusual anaplastic sarcomatoid giant cell morphology. Results Microscopically, a small separate PA was found adjacent to the carcinosarcoma. By conventional notion, the PA and carcinosarcoma would be considered related, as carcinosarcomas are well known to arise from PAs (carcinosarcoma ex PA). However, fluorescence in situ hybridization (FISH) assay demonstrated PLAG1 translocation in the carcinosarcoma and HMGA2 translocation in the separate PA. Conclusions These findings support that the carcinosarcoma likely originated from another PA with a PLAG1 translocation or de novo but not from the coexisting PA harboring a different translocation. To our knowledge, the case is the first to demonstrate PLAG1 translocation by FISH in a sarcomatous component of any parotid gland tumor, which may help better classify these tumors. In addition, multiple PAs are commonly found in the salivary gland, and to our knowledge, our case is the first to demonstrate that the same parotid gland can host PAs and PA-related tumors with different translocations.

Intraluminal crystalloids in malignant salivary gland tumours

1987 ◽  
Vol 101 (11) ◽  
pp. 1175-1181 ◽  
Author(s):  
Jae Y. Ro ◽  
Bruce Mackay ◽  
John G. Batsakis ◽  
Joiner Cartwright
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Parotid Glands ◽  
Salivary Duct ◽  
X Ray ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas

AbstractThe ultrastructural, X-ray microanalytical, histochemical and immunocytochemi-cal features of intraluminal crystalloids found in adenocarcinomas of the parotid gland have been studied. The crystalloids, putatively derived from an abnormal crystalization of salivary duct proteins, are considerably different from the crystalloids found in normal parotid glands, pleomorphic adenomas, and sialocysts.

Myoepithelial Carcinoma ex Pleomorphic Adenoma: Rare Case Report with Clinicopathologic and Immunohistochemical Features

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S86-S87
Author(s):  
M Khazaeli ◽  
Z Kamaluddin ◽  
M Taherian
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Nasal Passage ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Sublingual Gland ◽  
Myoepithelial Carcinoma ◽  
Minor Salivary Glands ◽  
Myoepithelial Differentiation ◽  
The Right

Abstract Introduction/Objective Myoepithelial carcinoma is identified by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. It occurs most commonly in the parotid gland followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Nasopharyngeal origin has been rarely reported. Methods/Case Report An afebrile 19-year-old female presented to the emergency department with persistent facial pressure, otalgia (right side greater than left side), rhinorrhea, and several episodes of epistaxis. One month before, she has been treated with Amoxicillin for three days with no relief, where Augmentin started for her for five days. About four days prior presentation, she was placed on Prednisone and Cefdinir. Over the next several days, she began having throat pain with difficulty swallowing. Routine blood work revealed a leukocytosis of 14.2 with normal differentiation. CT of the neck showed a large soft tissue mass centered at the right nasopharynx. Flexible nasal endoscopy performed bilaterally to reveal the nasopharynx is entirely obstructed with a lobulated mass filling the nasopharynx. On the right side, it extends into the posterior nasal passage filling the sphenoethmoid recess and the posterior floor of the nasal passage. Outpatient biopsy from nasopharynx mass is also performed. Results (if a Case Study enter NA) Mass biopsy reveals a mucinous and chondromyxoid background with mixed epithelial and myoepithelial differentiation. The is squamous metaplasia of myoepithelial cells and prominent mitotic activity and apoptotic activity. Immunohistochemistry was positive for CK5/6, calponin, BCL2, SMA, BerEp4, Sox10, and a proliferative index up to 40%. Based on this information Myoepithelial Carcinoma ex-pleomorphic adenoma of the nasopharynx is the diagnosis. Conclusion Carcinoma ex pleomorphic adenoma is usually a high-grade malignancy. It occurs most commonly in the parotid gland, followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Our case is one of the few cases of myoepithelial carcinoma arising in nasopharyngeal pleomorphic adenoma.

scholarly journals Salivary gland tumours - a three years experience at King Edward Medical College, Lahore

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Asmaa Qureshi ◽  
Khalilur Rehman ◽  
Sohail Husain ◽  
Nasirul Hasan Khawaja ◽  
Ghulam Rasood Qureshi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Single Case ◽  
Malignant Neoplasms ◽  
Salivary Gland Tumours ◽  
Medical College ◽  
Common Location ◽  
Female Predominance

Salivary gland tumours make an important part of oral & maxillofacial pathology. Only few studies have been done in Pakistani population. The aim of this study was to describe morphological types of salivary gland tumours diagnosed at King Edward Medical College/ Mayo Hospital, Lahore during the years 1999-2001 and to compare their demographic data with those previously published. Material & Methods: This descriptive cross-sectional study was carried out at King Edward Medical College/ Mayo Hospital, Lahore. It reports 117 cases of salivary gland tumours diagnosed at Pathology Department during 1999-2001. Results: Of the 128 specimens of salivary glands, 117(91.4%) were confirmed as salivary neoplasms. Out of them, 62.7% were benign and 37.6% malignant and a slight female predominance (58.1%) was found. The most common location was the parotid gland (65.8%) followed by minor salivary glands (19.6%). Majority oft he t tumours was diagnosed during 3rd to 5 decades of life. Median age for benign tumours was 33 years (range 1-78) and a female predominance (58.9%) was seen again. Median age for malignant neoplasms was 45 years (range 9-70) with a female predilection ( 56.8%). However, 4 out o f 5 patients with Warthin`s tumour were men. Pleomorphic adenoma was the most frequent tumour (51.3%), followed by mucoepidermoid carcinoma (25.6%), adenoid cystic carcinoma (7.7)), Warthin`s tumour (4.3%) and monomorphic adenoma (2.6%). Two cases each of oncytoma & adenocarcinoma were recorded. Rare categories (single case each) of salivary tumours included lipoma, acinic cell carcinoma, basal cell adenoma, capillary haemangioma, metastatic carcinoma and non Hodgkin`s lymphoma. Conclusion: The principal site of salivary tumours was the parotid gland and females were most affected. Pleomorphic adenoma was the most frequent finding. The results of this study are comparable with other studies.

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