Fifty years of woodworkers’ nasal adenocarcinoma in High Wycombe

Radiation therapy for three cases of suspect feline thymoma is described. The thymoma was controlled for 4 years in case no. 1. Case no. 2 responded well to radiation therapy but was euthanized after 2 months because of a nasal adenocarcinoma. Case no. 3 continues to do well more than 8 months after radiotherapy. Difficulties in diagnosing feline thymomas are discussed, and biological behavior as well as different treatment modalities of feline and human thymomas are compared.

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Nasal adenocarcinoma with diffuse metastases involving the orbit, cerebrum, and multiple cranial nerves in a horse

Journal of the American Veterinary Medical Association ◽

10.2460/javma.2002.221.1460 ◽

2002 ◽

Vol 221 (10) ◽

pp. 1460-1463 ◽

Cited By ~ 39

Author(s):

Jennifer L. Davis ◽

Brian C. Gilger ◽

Kathy Spaulding ◽

Ian D. Robertson ◽

Samuel L. Jones

Keyword(s):

Cranial Nerves ◽

Nasal Adenocarcinoma

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Nasal Adenocarcinoma in a 4-year-old Oriental Shorthair Cat

Sahel Journal of Veterinary Sciences ◽

10.54058/saheljvs.v17i3.141 ◽

2020 ◽

Vol 17 (3) ◽

pp. 45-48

Author(s):

J. S. M. Cheah ◽

I. A. Okene ◽

S. E. Todd ◽

C. Ruaux

Keyword(s):

Mass Effect ◽

Respiratory Sounds ◽

Nasal Discharge ◽

Viable Option ◽

Calvarial Bone ◽

Nasal Bridge ◽

Regional Lymph Nodes ◽

Bone Lysis ◽

Nasal Adenocarcinoma ◽

Adult Cat

The aim of this case report is to present a case of nasal adenocarcinoma in a young adult cat with underlying feline asthma. A 4-year-old, 2.3 kg, female Oriental Shorthair was referred to Massey University Veterinary Teaching Hospital with a rapidly expanding mass on its left nasal bridge and nasal discharge. Physical examination revealed stertorous respiratory sounds and a mass on the left nasal bridge measuring 3.2cm x 2.5 cm. Computed tomography of the nasal cavity showed mass effect in the left frontal sinus with extensive orbital bone lysis and loss of calvarial bone. Radiographs of the thorax showed possible evidence of metastasis. Fine needle aspirate was performed on the mass and also regional lymph nodes. Subsequently, nasal adenocarcinoma was diagnosed through cytology. Prognosis of the patient was poor as the patient’s condition was significantly complicated by asthma and possible lung metastasis. Palliative treatment was pursued using meloxicam as radiotherapy was not a viable option in this case.

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Nasal adenocarcinoma as a suspected secondary malignant neoplasm in a cat previously treated for nasal lymphoma

Journal of Feline Medicine and Surgery Open Reports ◽

10.1177/2055116920908351 ◽

2020 ◽

Vol 6 (1) ◽

pp. 205511692090835

Author(s):

Gabrielle F Callanan ◽

Kaitlin M Curran ◽

Cyril Parachini-Winter ◽

Shay Bracha ◽

Sean Spagnoli ◽

...

Keyword(s):

Radiation Therapy ◽

Radiation Treatment ◽

Present Report ◽

Clinical Signs ◽

Malignant Neoplasm ◽

Facial Swelling ◽

Nasal Adenocarcinoma ◽

Nasal Lymphoma ◽

Secondary Malignant Neoplasm ◽

Multiagent Chemotherapy

Case summary A case of nasal adenocarcinoma as a suspected secondary malignant neoplasm following definitive radiation therapy and multiagent chemotherapy for nasal lymphoma is described. An 11-year-old spayed female domestic shorthair cat was presented for a 3-week history of progressive facial swelling located over the nasal planum and extending to the medial canthus of the right eye. The cat was previously diagnosed with nasal lymphoma and treated with chemotherapy and definitive radiation 2.5 years prior. Although a definitive diagnosis could not be obtained via cytology, recurrent lymphoma was suspected based on the cat’s history and recurrent clinical signs. A lymphoma-directed chemotherapy protocol was attempted, but no clinical response was achieved. The cat was euthanased owing to progressive clinical signs and a diagnosis of nasal adenocarcinoma was made on necropsy examination. Both the original diagnosis of nasal lymphoma and the secondary diagnosis of nasal adenocarcinoma were confirmed with immunohistochemistry. Relevance and novel information Secondary malignant neoplasm following radiation therapy is infrequently reported in the veterinary literature. In the few reports that exist, most have described sarcoma development in the dog following radiation therapy. In the present report, we describe a cat with a suspected radiation-induced nasal adenocarcinoma that developed 2.5 years after definitive radiation treatment for nasal lymphoma.

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MRI findings, including diffusion-weighted imaging, in seven cats with nasal lymphoma and two cats with nasal adenocarcinoma

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x20932819 ◽

2020 ◽

pp. 1098612X2093281

Author(s):

Toshiyuki Tanaka ◽

Kazuna Ashida ◽

Yasumasa Iimori ◽

Hiroki Yamazaki ◽

Keiichiro Mie ◽

...

Keyword(s):

Diffusion Weighted Imaging ◽

Case Series ◽

Mri Findings ◽

Post Contrast ◽

Adc Value ◽

Diffusion Weighted ◽

Adc Values ◽

Nasal Adenocarcinoma ◽

Nasal Lymphoma ◽

Heterogeneous Enhancement

Objectives Case series summary Primary nasal tumours in cats are rare, with lymphoma being the most common feline nasal tumour, followed by adenocarcinoma. Although CT can reliably detect feline nasal tumours, there are no specific CT features that identify each tumour type. To our knowledge, there have been no reports describing MRI findings, including diffusion-weighted imaging (DWI), for nasal lymphomas and adenocarcinomas in cats. Therefore, this retrospective study aimed to evaluate the MRI findings of nasal lymphoma and adenocarcinoma, including qualitative and quantitative analysis of DWI. Methods MRI examination was performed on seven cats with histologically confirmed lymphoma and on two with adenocarcinoma. The MRI protocol included T2-weighted imaging (T2WI), T1-weighted imaging (T1WI) and DWI. Apparent diffusion coefficient (ADC) values were measured using DWI. Contrast agent was not used in one cat with lymphoma. Results In those with lymphoma, three (43%) were iso- and hyperintense on T2WI, seven (100%) were iso-intense on T1WI, five (83%) exhibited mild heterogeneous enhancement, including a prominent region of non-enhancement on post-contrast T1WI, and seven (100%) cats exhibited hyperintensity on DWI. The median ADC values were 0.45 × 10−3 mm2/s (range 0.37–0.53 × 10−3 mm2/s). For adenocarcinoma, two (100%) were iso- and hyperintense on T2WI, two (100%) were iso-intense on T1WI, two (100%) exhibited marked heterogeneous enhancement on post-contrast T1WI and two (100%) were iso-intense on DWI. The median ADC values were 1.08 × 10−3 mm2/s (range 0.88–1.27 × 10−3 mm2/s). The median ADC values of lymphoma tended to be lower than adenocarcinoma ( P = 0.056). Conclusions and relevance Determining ADC value and tumours with a large area of non-enhancement may be helpful in differentiating nasal lymphoma from nasal adenocarcinoma.

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Expression of nectin-4 as a potential biomarker in enzootic nasal adenocarcinoma of goats

Acta Veterinaria Hungarica ◽

10.1556/004.2016.008 ◽

2016 ◽

Vol 64 (1) ◽

pp. 71-77 ◽

Cited By ~ 1

Author(s):

Ahmet Aydoğan ◽

Özlem Özmen

Keyword(s):

Capra Hircus ◽

Strong Expression ◽

Potential Biomarker ◽

Nasal Adenocarcinoma ◽

Weak Expression

The aim of this study was to test nectin-4 by immunohistochemistry as a potential biomarker in enzootic nasal adenocarcinoma (ENA) of goats. Twentyfour archival ENA case samples [from 14 male and 10 female hair goats (Capra hircus)] were used. The samples were stained with haematoxylin and eosin (HE). Nectin-4 expression was studied by immunohistochemistry. By microscopy, tubular, papillary, and mixed patterns of ENA were diagnosed in the cases. Immunohistochemically, the tumours showed moderate nectin-4 expression (++) in 14 cases (58.3%), strong expression (+++) in five cases (20.8%), and weak expression (+) in three cases (12.5%), while two cases (8.3%) were negative. Normal nasal tissues were not stained with nectin-4. The results suggest that nectin-4 may be used as a valuable biomarker of ENA.

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