The saga of schistosome migration and attrition

Parasitology ◽  
2009 ◽  
Vol 136 (12) ◽  
pp. 1581-1592 ◽  
Author(s):  
R. A. WILSON
Keyword(s):  
Chronic Infection ◽  
Laboratory Mouse ◽  
Portal Tract ◽  
Portal System ◽  
Mammalian Host ◽  
Immune Mediated ◽  
Direct Penetration ◽  
Hepatic Portal System ◽  
Hepatic Portal ◽  
Kinetics Of

SUMMARYSchistosomes infect the mammalian host by direct penetration of the skin and must then undergo a protracted migration to the site of parasitization, forSchistosoma mansonithe hepatic portal vasculature. This article reviews the work published roughly between 1976 and 1986 that clarified our understanding of the process in the laboratory mouse. A combination of histopathology, larval injection experiments and autoradiographic tracking revealed that migration involved one to several circuits of the pulmonary-systemic vasculature before chance delivery in cardiac output to splanchnic arteries that lead indirectly to the portal tract. The kinetics of migration through different capillary beds was established, with the lungs of naïve mice not the skin proving the greatest obstacle; a proportion of schistosomula entered the alveoli from where they did not recover. The ‘immunity’ displayed by mice with a chronic infection was shown to be an artefact of a ‘leaky’ hepatic portal system, generated as a result of egg-induced hepatic pathology. The blockade of pulmonary migration was exacerbated in mice vaccinated with irradiated cercariae by immune-mediated inflammatory foci that developed around lung schistosomula thus decreasing the proportion that matured, but parasite elimination was a prolonged process, not an acute cytolytic ‘hit.’

An examination of the skin phase of schistosome migration using a hamster cheek pouch preparation

Parasitology ◽  
1980 ◽  
Vol 80 (2) ◽  
pp. 257-266 ◽  
Author(s):  
R. A. Wilson ◽  
J. Ruth Lawson
Keyword(s):  
Cheek Pouch ◽  
Surrounding Tissue ◽  
Portal System ◽  
Hamster Cheek Pouch ◽  
Post Exposure ◽  
Hepatic Portal System ◽  
65 H ◽  
The Mean ◽  
Hepatic Portal ◽  
Mean Time

SummaryA living hamster cheek pouch preparation has been used to study the skin phase of schistosomulum migration. Between 0 and 16 h post-exposure schistosomula become increasingly difficult to see and lateral movement in the skin ceases. Up to 50 h post-exposure they remain poorly visible. They lie in fluid-filled lacunae within the epidermis, external to the basement membrane. The first schistosomula enter the dermis from. 40 h post-exposure, approximately half having done so by 52·5 h. Coincidentally, they can be more easily distinguished from surrounding tissue. Up to 91% of original penetrants have been observed alive in. pouch tissue at 65 h post-exposure. Since only 26% eventually mature in the hepatic portal system there would appear to be considerable attrition subsequent to the skin phase of migration. The mean diameter of venules penetrated was 22·7 μm and the mean time taken to penetrate was 8·01 h. The majority of schistosomula left the pouch between 60 and 80 h post-exposure.

Occurrence and distribution of valves in the canine hepatic portal system

1988 ◽  
Vol 1 (1) ◽  
pp. 43-52 ◽  
Author(s):  
David L. Dawson ◽  
Carol E. H. Scott-Conner ◽  
Manuel E. Molina
Keyword(s):  
Portal System ◽  
Hepatic Portal System ◽  
Hepatic Portal

Automated anatomical labeling of abdominal arteries and hepatic portal system extracted from abdominal CT volumes

2015 ◽  
Vol 20 (1) ◽  
pp. 152-161 ◽  
Author(s):  
Tetsuro Matsuzaki ◽  
Masahiro Oda ◽  
Takayuki Kitasaka ◽  
Yuichiro Hayashi ◽  
Kazunari Misawa ◽  
...  
Keyword(s):  
Portal System ◽  
Abdominal Ct ◽  
Hepatic Portal System ◽  
Abdominal Arteries ◽  
Hepatic Portal

scholarly journals Genital Schistosomiasis: A Report on Two Cases of Ovarian Carcinomas Containing Viable Eggs ofSchistosoma mansoni

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Andressa Gonçalves Amorim ◽  
Fernanda Alves Barbosa Pagio ◽  
Rodrigo Neves Ferreira ◽  
Antônio Chambô Filho
Keyword(s):  
Schistosoma Mansoni ◽  
Benign Lesion ◽  
Parasitic Infection ◽  
Pelvic Mass ◽  
Abdominal Distension ◽  
Portal System ◽  
Serous Carcinoma ◽  
Ovarian Carcinomas ◽  
Hepatic Portal System ◽  
Hepatic Portal

Schistosomiasis is a parasitic infection that is highly prevalent worldwide, with a variety of species being responsible for causing the disease. In Brazil, however, the only identified species isSchistosoma mansoni. The adult parasites inhabit the blood vessels of the hepatic portal system of the main host. The disease may range from being asymptomatic to provoking liver damage or portal hypertension. Furthermore, ectopic schistosomiasis may develop, and several hypotheses have been raised to explain the occurrence of the disease. This paper describes two cases, one in a 39-year-old woman and the other in a 47-year-old woman. Both had similar symptoms of pain and abdominal distension caused by a large abdominal/pelvic mass. Histopathology of the ovary showed a mucinous cystadenocarcinoma of the intestinal type in the first patient and a papillary serous carcinoma in the second, with both tumors containing viable eggs ofSchistosoma mansoni. The neoplasms probably serve as a migratory route for the adult parasites and the embolization of eggs. Nevertheless, there is insufficient evidence to confirm the malignization of a benign lesion due to the presence ofSchistosoma mansoni. Few cases have been reported in the international literature on the association between ovarian schistosomiasis and neoplasms.

scholarly journals Morphological studies of the canine hepatic portal system

2018 ◽  
Vol 21 (4) ◽  
pp. 406-419
Author(s):  
G. Georgiev ◽  
I. Raychev ◽  
N. Mehandzhiyski ◽  
L. Hristakiev ◽  
G. Georgiev ◽  
...  
Keyword(s):  
Portal System ◽  
Morphological Studies ◽  
Hepatic Portal System ◽  
Hepatic Portal

scholarly journals POLIESPLENIA E ANOMALIA DO SISTEMA PORTAL HEPÁTICO ASSOCIADAS À AUSÊNCIA DE VEIA CAVA INFERIOR EM CRIANÇA: RELATO DE CASO

2021 ◽  
Vol 12 (3) ◽  
pp. 102-105
Author(s):  
Lucas Cavalcanti dos Santos ◽  
Eloisa Nascimento Jorge ◽  
Luciana Alvares Calvo ◽  
Janilson de Souza Cavalcante
Keyword(s):  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Vena Cava ◽  
Azygos Vein ◽  
Abdominal Ultrasound ◽  
Portal System ◽  
Vein Thrombosis ◽  
Cardiovascular Malformation ◽  
Hepatic Portal System ◽  
Hepatic Portal

Agenesis of inferior vena cava (IVC)is a rare cardiovascular malformation that occurs between the sixth and tenth week of embryogenesis. It may be associated with cardiac and abdominal malformations, besidescomplications such as deep vein thrombosis (DVT). The present study reports the case of a patient randomly diagnosed with total IVC agenesis associated with malformation of the portohepatic system and polysplenia. Female patient, 9 years old, being monitored for hemorrhagic dengue, withcomputed tomographyand abdominal ultrasound revealing anomaly of the development of the hepatic portal system associated with the absence of inferior vena cava with continuation inretrocrural azygos vein, in addition to multiple accessory spleens. When the anastomoses of the IVCprimitive veins are not formed properly, partial or total agenesis of this vessel may occur. Consequently, the blood is diverted to the retrocrural azygos. Identification of these malformations is important for the patients receive proper guidance about DVT prevention, in additionto monitoring them for diagnosis of other possible malformations.

Sign in / Sign up

Export Citation Format

Share Document