Effects of tDCS during inhibitory control training on performance and PTSD, aggression and anxiety symptoms: a randomized-controlled trial in a military sample

Abstract Background Post-traumatic stress disorder (PTSD), anxiety, and impulsive aggression are linked to transdiagnostic neurocognitive deficits. This includes impaired inhibitory control over inappropriate responses. Prior studies showed that inhibitory control can be improved by modulating the right inferior frontal gyrus (IFG) with transcranial direct current stimulation (tDCS) in combination with inhibitory control training. However, its clinical potential remains unclear. We therefore aimed to replicate a tDCS-enhanced inhibitory control training in a clinical sample and test whether this reduces stress-related mental health symptoms. Methods In a preregistered double-blind randomized-controlled trial, 100 active-duty military personnel and post-active veterans with PTSD, anxiety, or impulsive aggression symptoms underwent a 5-session intervention where a stop-signal response inhibition training was combined with anodal tDCS over the right IFG for 20 min at 1.25 mA. Inhibitory control was evaluated with the emotional go/no-go task and implicit association test. Stress-related symptoms were assessed by self-report at baseline, post-intervention, and after 3-months and 1-year follow-ups. Results Active relative to sham tDCS neither influenced performance during inhibitory control training nor on assessment tasks, and did also not significantly influence self-reported symptoms of PTSD, anxiety, impulsive aggression, or depression at post-assessment or follow-up. Conclusions Our results do not support the idea that anodal tDCS over the right IFG at 1.25 mA enhances response inhibition training in a clinical sample, or that this tDCS-training combination can reduce stress-related symptoms. Applying different tDCS parameters or combining tDCS with more challenging tasks might provide better conditions to modulate cognitive functioning and stress-related symptoms.

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Randomized-controlled trial of response inhibition training for individuals with PTSD and impaired response inhibition

Behaviour Research and Therapy ◽

10.1016/j.brat.2021.103885 ◽

2021 ◽

pp. 103885

Author(s):

Aileen Echiverri-Cohen ◽

Lucas Spierer ◽

Marcelina Perez ◽

Melissa Kulon ◽

Montana Daunbi Ellis ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Response Inhibition ◽

Controlled Trial ◽

Randomized Controlled ◽

Inhibition Training

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Supplemental Material for A Randomized Controlled Trial of Inhibitory Control Training for the Reduction of Alcohol Consumption in Problem Drinkers

Journal of Consulting and Clinical Psychology ◽

10.1037/ccp0000312.supp ◽

2018 ◽

Keyword(s):

Randomized Controlled Trial ◽

Alcohol Consumption ◽

Inhibitory Control ◽

Controlled Trial ◽

Problem Drinkers ◽

Randomized Controlled

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Faculty Opinions recommendation of Acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample: a randomized controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13404991.14775103 ◽

2011 ◽

Author(s):

Rona Levy

Keyword(s):

Randomized Controlled Trial ◽

Irritable Bowel Syndrome ◽

Cost Effectiveness ◽

Clinical Sample ◽

Controlled Trial ◽

Exposure Treatment ◽

Randomized Controlled ◽

Irritable Bowel

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Impact of second forward-view examination on adenoma detection rate during unsedated colonoscopy: a randomized controlled trial

BMC Gastroenterology ◽

10.1186/s12876-021-01783-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Keshu Shan ◽

Hongpeng Lu ◽

Zhixin Zhang ◽

Jiarong Xie ◽

Lu Xu ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Detection Rate ◽

Controlled Trial ◽

Lesion Detection ◽

Adenoma Detection Rate ◽

Right Colon ◽

Randomized Controlled ◽

Adenoma Detection ◽

Advanced Lesion ◽

The Right

Abstract Objectives Colorectal cancer on the right side of the colon has been suggested to be harder to detect by colonoscopy. The aim of this study was to evaluate whether a second forward-view examination of the right side of the colon could increase the adenoma detection rate (ADR) and/or polyp detection rate (PDR). Methods This was a single-centre randomized controlled trial. Patients undergoing colonoscopy were recruited and randomly assigned to the second forward-view examination (SFE) group, in which the right side of the colon was examined twice or the traditional colonoscopy (TC) group in which the colonoscopy was performed in a standard manner. The primary outcome was the ADR of right colon. The overall PDR and ADR, PDR of the right colon, per-adenoma miss rate of the right colon, and advanced lesion detection rate were also recorded and compared. Results A total of 392 patients were included in the study (SFE group 197 vs. TC group 195). The ADR and PDR of the right colon in the SFE group were significantly higher than those in the TC group (ADR 10.7% vs. 5.1%; P = 0.042); PDR 17.8% vs. 9.7%, P = 0.021). No significant difference was found in overall PDR/ADR, or advanced lesion detection rate between the two groups. Conclusions This prospective controlled study revealed that a second forward-view examination could modestly increase the ADR and PDR of the right colon during unsedated colonoscopies. This simple, safe and time-effective technique might be recommended for routine unsedated colonoscopy. Trial registration: Clinical Trials.gov, NCT03619122. Registered on 7/8/2018.

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Cognitive control training for urgency: A pilot randomized controlled trial in an acute clinical sample

Behaviour Research and Therapy ◽

10.1016/j.brat.2021.103968 ◽

2021 ◽

Vol 146 ◽

pp. 103968

Author(s):

Andrew D. Peckham ◽

Jenna P. Sandler ◽

Devin Dattolico ◽

R. Kathryn McHugh ◽

Daniel S. Johnson ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Control ◽

Clinical Sample ◽

Controlled Trial ◽

Randomized Controlled ◽

Cognitive Control Training ◽

Pilot Randomized Controlled Trial

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A randomized controlled trial of inhibitory control training for the reduction of alcohol consumption in problem drinkers.

Journal of Consulting and Clinical Psychology ◽

10.1037/ccp0000312 ◽

2018 ◽

Vol 86 (12) ◽

pp. 991-1004 ◽

Cited By ~ 16

Author(s):

Andrew Jones ◽

Elly McGrath ◽

Eric Robinson ◽

Katrijn Houben ◽

Chantal Nederkoorn ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Alcohol Consumption ◽

Inhibitory Control ◽

Controlled Trial ◽

Problem Drinkers ◽

Randomized Controlled

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Patient and therapist experiences of using affordable feedback-based technology in rehabilitation: a qualitative study nested in a randomized controlled trial

Clinical Rehabilitation ◽

10.1177/0269215518771820 ◽

2018 ◽

Vol 32 (9) ◽

pp. 1258-1270 ◽

Cited By ~ 7

Author(s):

Caitlin Hamilton ◽

Annie McCluskey ◽

Leanne Hassett ◽

Maggie Killington ◽

Meryl Lovarini

Keyword(s):

Randomized Controlled Trial ◽

Qualitative Study ◽

Patient Engagement ◽

Controlled Trial ◽

Aged Care ◽

Theory Approach ◽

Post Discharge ◽

Randomized Controlled ◽

The Right ◽

Two Stages

Objective: To explore how technologies are used and experienced in rehabilitation. Design: A qualitative study using a grounded theory approach within a randomized controlled trial investigating the effectiveness of tailored, affordable technologies to improve mobility and physical activity. Settings: Aged care and neurological rehabilitation wards with community follow-up. Participants: Twenty patients undergoing rehabilitation and randomized to the experimental arm of a trial (mean age 64 years (SD 23)) were recruited for interviews, plus 11 physiotherapists involved in technology prescription as part of the trial. Method: Two interviews per patient (one in hospital, one post-discharge) and four focus groups with physiotherapists were conducted. Transcribed data were coded and synthesized. Memo-writing and constant comparison methods guided data analysis. Results: A process of patient engagement with technology involving two stages: (1) initial patient engagement and (2) maintaining patient engagement was identified. Therapists used a series of steps and strategies to gain and maintain patient engagement. A positive first experience and continued input into patient programmes was needed. The level of patient engagement was not consistent across the duration of the trial, increasing or decreasing due to changes in the technologies prescribed or setting of use. Two conditions were key to optimizing patient engagement: sufficient support and perceived benefit from using technology. Conclusions: Patients can engage with technology during rehabilitation when prescription is tailored by a therapist. Perceiving benefit from using technology, in addition to receiving the right support to enable use appears to influence the level of patient engagement.

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A preinstalled nasopharyngeal airway in the right nasal passageway to facilitate nasogastric intubation in anesthetized and intubated patients: a prospective randomized controlled trial

BMC Gastroenterology ◽

10.1186/s12876-020-01514-6 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Ting-Yang Huang ◽

Jr-Rung Lin ◽

Yung-Tai Chung

Keyword(s):

Randomized Controlled Trial ◽

Success Rate ◽

Risk Reduction ◽

Controlled Trial ◽

Success Rates ◽

Randomized Controlled ◽

Prospective Randomized Controlled Trial ◽

Nasopharyngeal Airway ◽

The Right ◽

To Receive

Abstract Background Nasogastric intubation (NGI) is usually challenging in patients under general anesthesia, with reported success rate at the first attempt to be less than 50%. The aim of this study was to investigate whether a preinstalled nasopharyngeal airway (NPA) in the right nasal passageway can facilitate NGI in anesthetized and intubated patients. Methods A prospective randomized controlled trial including 108 patients scheduled for elective intra-abdominal surgeries requiring a nasogastric tube (NGT) was conducted. Fifty-three patients were randomized to receive NGI through a preinstalled NPA in the right nasal passageway (Group NPA) and 55 patients to receive NGI via the right nostril (Group O). The primary outcomes were success rates of NGI at first attempt, success rates of NGI in accumulative attempts, durations of successful NGI at the first attempt and success rates of NGI for the rescuing methods. The secondary outcomes were bleeding incidence and hemodynamic changes induced by NGI. Results Success rate of NGI at the first attempt was 83.0% in Group NPA compared with 47.3% in Group O [P < 0.001; absolute risk reduction (ARR) = 35.7%, 95% confidence interval (CI) = 19.1–52.4%; relative risk reduction (RRR) = 67.8%] and success rate of NGI in accumulative attempts (two attempts maximum) was 88.7% in Group NPA compared with 63.6% in Group O (P = 0.002; ARR = 25.0%, 95% CI = 9.7–40.4%; RRR = 68.9%). Duration for NGI successful at the first attempt in Group NPA was significantly longer than that in Group O (56.3 vs. 27.1 s; P < 0.001; Mean difference = 29.2 s, 95% CI = 20.0–38.4 s). Neither bleeding incidence nor hemodynamic response is significantly different between the two study groups. Conclusions The study indicates a preinstalled NPA in the right nasal passageway facilitates NGI in anesthetized and intubated patients as an initial NGI method and as a rescuing method for patients undergoing two unsuccessful initial attempts of NGI without a preinstalled NPA. However, the NPA method proved to take more time than the routine method for NGI successful at the first attempt. Trial registration: The study was conducted after receiving approval from Institutional Review Board of Chang Gung Memorial Hospital, Linkou branch, Taiwan (registration number 201800138A3; April 11, 2018), and the clinicaltrials.gov (NCT03697642; Principal Investigator: Ting-Yang Huang; Date of registration: October 4, 2018; https://www.clinicaltrials.gov/NCT03697642).

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