scholarly journals Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

2021 ◽  
pp. 1-10
Author(s):  
Jessica Mundy ◽  
Christopher Hübel ◽  
Joel Gelernter ◽  
Daniel Levey ◽  
Robin M. Murray ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Stress Disorder ◽  
Genetic Correlations ◽  
Psychological Trauma ◽  
Major Depressive ◽  
Single Episode ◽  
Genetic Overlap ◽  
Genetic Loading

Abstract Background Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly reported co-occurring mental health consequences of psychological trauma exposure. The disorders have high genetic overlap. Trauma is a complex phenotype but research suggests that trauma sensitivity has a heritable basis. We investigated whether sensitivity to trauma in those with MDD reflects a similar genetic component in those with PTSD. Methods Genetic correlations between PTSD and MDD in individuals reporting trauma and MDD in individuals not reporting trauma were estimated, as well as with recurrent MDD and single-episode MDD, using genome-wide association study (GWAS) summary statistics. Genetic correlations were replicated using PTSD data from the Psychiatric Genomics Consortium and the Million Veteran Program. Polygenic risk scores were generated in UK Biobank participants who met the criteria for lifetime MDD (N = 29 471). We investigated whether genetic loading for PTSD was associated with reporting trauma in these individuals. Results Genetic loading for PTSD was significantly associated with reporting trauma in individuals with MDD [OR 1.04 (95% CI 1.01–1.07), Empirical-p = 0.02]. PTSD was significantly more genetically correlated with recurrent MDD than with MDD in individuals not reporting trauma (rg differences = ~0.2, p < 0.008). Participants who had experienced recurrent MDD reported significantly higher rates of trauma than participants who had experienced single-episode MDD (χ2 > 166, p < 0.001) Conclusions Our findings point towards the existence of genetic variants associated with trauma sensitivity that might be shared between PTSD and MDD, although replication with better powered GWAS is needed. Our findings corroborate previous research highlighting trauma exposure as a key risk factor for recurrent MDD.

scholarly journals Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

2020 ◽  
Author(s):  
Jessica Mundy ◽  
Christopher Hübel ◽  
Joel Gelernter ◽  
Daniel Levey ◽  
Robin M. Murray ◽  
...  
Keyword(s):  
Mental Health ◽  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Genetic Risk ◽  
Stress Disorder ◽  
Genetic Correlations ◽  
Psychological Trauma ◽  
Major Depressive ◽  
Single Episode ◽  
Genetic Overlap

AbstractBackgroundPosttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly reported co-occurring mental health consequences following psychological trauma exposure. The disorders have high genetic overlap. We investigated whether the genetics of PTSD were associated with reported trauma in individuals with MDD. Since trauma is associated with recurrent MDD, we also investigated whether the genetics of PTSD were associated with episode recurrence.MethodsGenetic correlations were estimated between PTSD and MDD in the presence and MDD in the absence of reported exposure to psychological trauma, and recurrent and single-episode MDD, based on genetic data from UK Biobank Mental Health Questionnaire respondents (N=157,358). Genetic correlations were replicated using PTSD data from the Psychiatric Genomics Consortium and Million Veteran Program. Polygenic risk scores were generated to investigate whether individuals with MDD who have higher genetic risk for PTSD were more likely to report psychological trauma than those with lower genetic risk.ResultsIndividuals with MDD with a higher genetic risk for PTSD were significantly more likely to report exposure to psychological trauma than those with lower risk [OR=1.06 (1.03-1.09) Empricial p<0.001]. PTSD was significantly more genetically correlated with recurrent MDD than with MDD in the absence of reported psychological trauma [rg differences = ∼0.2, p<0.008]. Participants who had experienced recurrent depressive episodes reported significantly higher trauma rates than participants who had experienced a single episode [chisquare>167, p<0.001].ConclusionsGenetic risk for PTSD in individuals with MDD may influence the way in which traumatic life events are perceived, responded to and reported.

scholarly journals Hemicrania Continua Headache in a Veteran with Posttraumatic Stress Disorder and Major Depressive Disorder without Traumatic Brain Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Brandon A. Kohrt ◽  
Erica Duncan
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Psychiatric Symptoms ◽  
Hemicrania Continua ◽  
Major Depressive ◽  
High Flow Oxygen ◽  
Psychopharmacological Intervention

Hemicrania continua is a headache characterized by chronic unremitting unilateral pain associated with ipsilateral autonomic findings. This type of headache responds to high-flow oxygen and indomethacin. This case report describes a male veteran with posttraumatic stress disorder (PTSD) and major depressive disorder who suffers from comorbid hemicrania continua. The psychiatric symptoms were recalcitrant to psychopharmacological intervention. However, when the patient's hemicrania continua was treated appropriately, the patient's psychiatric symptoms also abated. This case demonstrates the need to address physical comorbidities that may exacerbate psychiatric disorders, such as PTSD.

scholarly journals Posttraumatic stress disorder: a serious post-earthquake complication

2017 ◽  
Vol 39 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Mudassir Farooqui ◽  
Syed A. Quadri ◽  
Sajid S. Suriya ◽  
Muhammad Adnan Khan ◽  
Muhammad Ovais ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Psychological Symptoms ◽  
Relevant Information ◽  
Health Condition ◽  
Major Depressive ◽  
Compulsive Disorder

Abstract Objectives Earthquakes are unpredictable and devastating natural disasters. They can cause massive destruction and loss of life and survivors may suffer psychological symptoms of severe intensity. Our goal in this article is to review studies published in the last 20 years to compile what is known about posttraumatic stress disorder (PTSD) occurring after earthquakes. The review also describes other psychiatric complications that can be associated with earthquakes, to provide readers with better overall understanding, and discusses several sociodemographic factors that can be associated with post-earthquake PTSD Method A search for literature was conducted on major databases such as MEDLINE, PubMed, EMBASE, and PsycINFO and in neurology and psychiatry journals, and many other medical journals. Terms used for electronic searches included, but were not limited to, posttraumatic stress disorder (PTSD), posttraumatic symptoms, anxiety, depression, major depressive disorder, earthquake, and natural disaster. The relevant information was then utilized to determine the relationships between earthquakes and posttraumatic stress symptoms. Results It was found that PTSD is the most commonly occurring mental health condition among earthquake survivors. Major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social phobia, and specific phobias were also listed. Conclusion The PTSD prevalence rate varied widely. It was dependent on multiple risk factors in target populations and also on the interval of time that had elapsed between the exposure to the deadly incident and measurement. Females seemed to be the most widely-affected group, while elderly people and young children exhibit considerable psychosocial impact.

Examining the latent structure mechanisms for comorbid posttraumatic stress disorder and major depressive disorder

2018 ◽  
Vol 229 ◽  
pp. 477-482 ◽  
Author(s):  
Margo C. Hurlocker ◽  
Desirae N. Vidaurri ◽  
Lisa-Ann J. Cuccurullo ◽  
Kelly Maieritsch ◽  
C. Laurel Franklin
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Latent Structure ◽  
Major Depressive
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