Neurotrophic factors, neuronal selectionism, and neuronal proliferation

Quartz & Sejnowski (Q&S) disregard evidence that suggests that their view of dendrites is inadequate and they ignore recent results concerning the role of neurotrophic factors in synaptic remodelling. They misrepresent neuronal selectionism and thus erect a straw-man argument. Finally, the results discussed in section 4.2 require neuronal proliferation, but this does not occur during the period of neuronal development of relevance here.

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Role of neurotrophic factors in neuronal development

Current Opinion in Neurobiology ◽

10.1016/s0959-4388(96)80010-9 ◽

1996 ◽

Vol 6 (1) ◽

pp. 64-70 ◽

Cited By ~ 197

Author(s):

Christopher E Henderson

Keyword(s):

Neurotrophic Factors ◽

Neuronal Development

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Tcf4 Is Involved in Subset Specification of Mesodiencephalic Dopaminergic Neurons

Biomedicines ◽

10.3390/biomedicines9030317 ◽

2021 ◽

Vol 9 (3) ◽

pp. 317

Author(s):

Simone Mesman ◽

Iris Wever ◽

Marten P. Smidt

Keyword(s):

Neuronal Differentiation ◽

Dopaminergic Neurons ◽

Neuronal Development ◽

Neuronal Population ◽

Minor Role ◽

Initial Increase ◽

E Box ◽

A Minor ◽

Bhlh Factor

During development, mesodiencephalic dopaminergic (mdDA) neurons form into different molecular subsets. Knowledge of which factors contribute to the specification of these subsets is currently insufficient. In this study, we examined the role of Tcf4, a member of the E-box protein family, in mdDA neuronal development and subset specification. We show that Tcf4 is expressed throughout development, but is no longer detected in adult midbrain. Deletion of Tcf4 results in an initial increase in TH-expressing neurons at E11.5, but this normalizes at later embryonic stages. However, the caudal subset marker Nxph3 and rostral subset marker Ahd2 are affected at E14.5, indicating that Tcf4 is involved in correct differentiation of mdDA neuronal subsets. At P0, expression of these markers partially recovers, whereas expression of Th transcript and TH protein appears to be affected in lateral parts of the mdDA neuronal population. The initial increase in TH-expressing cells and delay in subset specification could be due to the increase in expression of the bHLH factor Ascl1, known for its role in mdDA neuronal differentiation, upon loss of Tcf4. Taken together, our data identified a minor role for Tcf4 in mdDA neuronal development and subset specification.

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Dissecting the role of redox signaling in neuronal development

Journal of Neurochemistry ◽

10.1111/jnc.13581 ◽

2016 ◽

Vol 137 (4) ◽

pp. 506-517 ◽

Cited By ~ 35

Author(s):

Daniel A. Bórquez ◽

Pamela J. Urrutia ◽

Carlos Wilson ◽

Brigitte van Zundert ◽

Marco Tulio Núñez ◽

...

Keyword(s):

Neuronal Development ◽

Redox Signaling

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Expression of KCa channels in identified populations of developing vertebrate neurons: role of neurotrophic factors and activity

Journal of Physiology-Paris ◽

10.1016/j.jphysparis.2003.10.006 ◽

2003 ◽

Vol 97 (1) ◽

pp. 49-58 ◽

Cited By ~ 16

Author(s):

S Dryer

Keyword(s):

Neurotrophic Factors ◽

Kca Channels

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Role of neurotrophic factors in attention deficit hyperactivity disorder

Cytokine & Growth Factor Reviews ◽

10.1016/j.cytogfr.2016.11.003 ◽

2017 ◽

Vol 34 ◽

pp. 35-41 ◽

Cited By ~ 20

Author(s):

Shih-Jen Tsai

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Attention Deficit ◽

Neurotrophic Factors ◽

Hyperactivity Disorder

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Functions of Sleep

Physiological Research ◽

10.33549/physiolres.934470 ◽

2021 ◽

pp. 177-182

Author(s):

E Miletínová ◽

J Bušková

Keyword(s):

Neuronal Development ◽

Well Being ◽

Main Function ◽

Complex Issue ◽

Complex Process ◽

Scientific Papers ◽

System Functioning ◽

Function Of Sleep ◽

The Individual

Sleep is essential component of life. Even though the research in this field develops constantly, there are still many aspects of this rather complex process that remains to be fully clarified. One of these aspects, reason why we actually sleep, is perhaps the most crucial. In this mini review we aim to address this question and discuss potential functions of sleep. Many recent scientific papers are currently available that covers similar topic. We tried to summarize these recent findings. There are certainly many ways how to approach this rather complex issue. Our article will specifically focus on role of sleep in neuronal development, synaptic plasticity, memory consolidation or mental health in general. Its role in immune system functioning will also be mentioned. Moreover, we will also consider more general functions of sleep, such as well-being of the organisms or securing survival of the individual. In conclusion, we will highlight possible main function of sleep.

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