Neonatal Surfactant Deficiency and Surfactant Replacement Therapy

1991 ◽  
Vol 7 (S1) ◽  
pp. 21-25 ◽  
Author(s):  
Mikko Hallman ◽  
Maija Pohjavuori ◽  
Kristiina Bry ◽  
T. Allen Merritt
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Replacement Therapy ◽  
Prospective Studies ◽  
Distress Syndrome ◽  
Surfactant Replacement ◽  
The Past ◽  
Surfactant Deficiency ◽  
Surfactant Replacement Therapy ◽  
Accepted Form

For the past 25 years, attempts have been made to treat respiratory distress syndrome (RDS) by administration of surfactant into the airways. This practice is not yet an accepted form of therapy. Lack of generally available surfactant during the present era of prospective studies will hopefully decrease the therapeutic misuse of this novel medicine.

scholarly journals Surfactant Replacement Therapy for Respiratory Distress Syndrome in the Newborn: A Review

2017 ◽  
Vol 40 (1) ◽  
pp. 26-30
Author(s):  
Tahsinul Amin ◽  
Mohammod Shahidullah
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Pulmonary Hemorrhage ◽  
Surfactant Therapy ◽  
Respiratory Morbidity ◽  
Exogenous Surfactant ◽  
Surfactant Replacement ◽  
Surfactant Deficiency ◽  
Surfactant Replacement Therapy

Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in low birth weight premature infants. Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Exogenous surfactant therapy has become well established in newborn infants with respiratory distress. Many aspects of its use have been well evaluated in high-quality trials and systematic reviews. Secondary surfactant deficiency also contributes to acute respiratory morbidity in late-preterm and term neonates with meconium aspiration syndrome, pneumonia/ sepsis, and perhaps pulmonary hemorrhage; surfactant replacement may be beneficial for these infants. This article summarizes the evidence and gives recommendations for the use of surfactant therapy for respiratory distress syndrome (RDS) in newborn.Bangladesh J Child Health 2016; VOL 40 (1) :26-30

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