A decade of biological psychiatric research on OCD (I): introduction and treatment-studies

1993 ◽  
Vol 5 (1) ◽  
pp. 1-6 ◽  
Author(s):  
A.S. De Leeuw ◽  
J.A. Den Boer ◽  
H.G.M. Westenberg
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Therapeutic Effect ◽  
Dopaminergic System ◽  
Psychiatric Research ◽  
Pharmacologic Treatment ◽  
Obsessive Compulsive ◽  
Short Introduction ◽  
Adaptive Changes ◽  
Compulsive Disorder ◽  
Antidepressant Effects

SummaryIn this first part of a review on biological psychiatric aspects of obsessive-compulsive disorder (OCD), firstly a short introduction is given about historical, diagnostic and epidemiological issues concerning OCD. Subsequently pharmacologic treatment-studies are discussed. Only serotonin (5-HT) reuptake blockers are proven to be effective. There is accumulating evidence that this therapeutic effect is not due to antidepressant effects. The results of the treatment-studies strongly suggests that 5-HT is involved in OCD. CSF-studies seem to confirm this. Possibly the therapeutic effect is related with adaptive changes of 5-HT receptors. There is evidence that in a subgroup of O CD-patients the dopaminergic system is involved.

Quality of Life in Obsessive-Compulsive Disorder

CNS Spectrums ◽  
2000 ◽  
Vol 5 (S4) ◽  
pp. 37-39 ◽  
Author(s):  
Dan J. Stein ◽  
Andrea Allen ◽  
Julio Bobes ◽  
Jane L. Eisen ◽  
M. L. Figuera ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Obsessive Compulsive Disorder ◽  
World Economy ◽  
Negative Impact ◽  
General Medicine ◽  
Psychiatric Research ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Occupational Function

AbstractThe construct of quality of life (QOL), which has both subjective and objective components, has gained increasing importance in psychiatric research for several important reasons, not the least being the current importance of pharmacoeconomic issues. Obsessive-compulsive disorder (OCD) has been suggested to be the worlds 10th most disabling disorder, and pharmacoeconomic studies have indicated that its cost to the world economy runs into the billions of dollars. The use of QOL scales derived from general medicine and other areas of psychiatry has demonstrated the enormous negative impact of OCD on several domains, including occupational function, social function, and family function. Further work to ascertain the extent of changes in QOL during treatment of OCD is necessary.

scholarly journals Dopaminergic System Alteration in Anxiety and Compulsive Disorders: A Systematic Review of Neuroimaging Studies

2020 ◽  
Vol 14 ◽  
Author(s):  
Mei-Xue Dong ◽  
Guang-Hui Chen ◽  
Ling Hu
Keyword(s):  
Systematic Review ◽  
Anxiety Disorder ◽  
Dopamine Transporter ◽  
Obsessive Compulsive Disorder ◽  
Dopaminergic System ◽  
Sensitivity Analyses ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Meta Analyses ◽  
Compulsive Disorders

Objective: The dopaminergic system is involved in many psychiatric disorders as a GABAergic, serotonergic, and glutamatergic system. A systematic review and meta-analysis was performed to elucidate the alteration of the dopaminergic system in anxiety and compulsive disorders.Methods: The databases of Pubmed, Embase, and ScienceDirect were searched and articles reporting the involvement of the dopaminergic system in patients with anxiety disorder and obsessive compulsive disorder (OCD) were recognized. The key research data were extracted from the included articles and standardized mean differences were calculated using meta-analyses if there were more than two studies with obtainable data. Sensitivity analyses were further performed to detect the stability of results, and the qualities of all the included studies were assessed using the Newcastle Ottawa scale.Results: Finally, we identified 8 and 11 studies associated with anxiety disorder and OCD for further analysis, respectively. Most consistently, the striatal dopamine D2 receptor (D2R) of OCD patients had decreased while no significant correlation was found between striatal D2R and disease severity. The striatal dopamine transporter (DAT) had not been significantly altered in both the anxiety disorder and OCD patients. The heterogeneity values from the meta-analyses were extremely high while those results remained stable after sensitivity analyses. Inconsistent data were found in the striatal D2R of patients with anxiety disorder. Limited data had suggested that dopamine synthesis increased in most regions of the cerebral cortex and cerebellum in OCD patients.Conclusions: The most convincing finding was that the D2 receptor decreased in patients with obsessive compulsive disorder. The dopamine transporter may have no relationship with anxiety and compulsive disorder.

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