Molecular phylogenetic and evolutionary analysis of Japanese encephalitis virus in China

2011 ◽  
Vol 140 (9) ◽  
pp. 1637-1643 ◽  
Author(s):  
S. P. CHEN
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Envelope Protein ◽  
Purifying Selection ◽  
Encephalitis Virus ◽  
Evolutionary Analysis ◽  
Genotype I ◽  
Genotype Iii ◽  
Molecular Phylogenetic ◽  
Low Prevalence

SUMMARYWe elucidated the molecular epidemiology and evolution of Japanese encephalitis virus (JEV) strains isolated from 1949 to 2009 in China in this study. Three genotypes (I, III, V) were confirmed to be co-circulating in China in both high- and low-prevalence areas. Genotype III consisted of two clades (mainland clade and Taiwan clade). Compared to the mainland clade, genotype I and the Taiwan clade were newly introduced and evolved more rapidly. We also demonstrated that JEV strains in China, especially those in the mainland clade, were not only under purifying selection, but also probably under positive selection (aa 227 and 408 in the envelope protein).

scholarly journals Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 357
Author(s):  
Muddassar Hameed ◽  
Abdul Wahaab ◽  
Mohsin Nawaz ◽  
Sawar Khan ◽  
Jawad Nazir ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Zoonotic Transmission ◽  
In Vivo Studies ◽  
Genotype I ◽  
Genotype Iii

Japanese encephalitis (JE) is a vaccine-preventable disease caused by the Japanese encephalitis virus (JEV), which is primarily prevalent in Asia. JEV is a Flavivirus, classified into a single serotype with five genetically distinct genotypes (I, II, III, IV, and V). JEV genotype III (GIII) had been the most dominant strain and caused numerous outbreaks in the JEV endemic countries until 1990. However, recent data shows the emergence of JEV genotype I (GI) as a dominant genotype and it is gradually displacing GIII. The exact mechanism of this genotype displacement is still unclear. The virus can replicate in mosquito vectors and vertebrate hosts to maintain its zoonotic life cycle; pigs and aquatic wading birds act as an amplifying/reservoir hosts, and the humans and equines are dead-end hosts. The important role of pigs as an amplifying host for the JEV is well known. However, the influence of other domestic animals, especially birds, that live in high abundance and close proximity to the human is not well studied. Here, we strive to briefly highlight the role of birds in the JEV zoonotic transmission, discovery of birds as a natural reservoirs and amplifying host for JEV, species of birds susceptible to the JEV infection, and the proposed effect of JEV on the poultry industry in the future, a perspective that has been neglected for a long time. We also discuss the recent in vitro and in vivo studies that show that the newly emerged GI viruses replicated more efficiently in bird-derived cells and ducklings/chicks than GIII, and an important role of birds in the JEV genotype shift from GIII to GI.

scholarly journals The emerged genotype I of Japanese encephalitis virus shows an infectivity similar to genotype III in Culex pipiens mosquitoes from China

2019 ◽  
Vol 13 (9) ◽  
pp. e0007716 ◽  
Author(s):  
Muddassar Hameed ◽  
Ke Liu ◽  
Muhammad Naveed Anwar ◽  
Abdul Wahaab ◽  
Anum Safdar ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Culex Pipiens ◽  
Encephalitis Virus ◽  
Genotype I ◽  
Genotype Iii

scholarly journals Investigation of the genotype III to genotype I shift in Japanese encephalitis virus and the impact on human cases

2015 ◽  
Vol 30 (4) ◽  
pp. 277-289 ◽  
Author(s):  
Na Han ◽  
James Adams ◽  
Wei Fang ◽  
Si-Qing Liu ◽  
Simon Rayner
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Genotype I ◽  
Genotype Iii ◽  
The Impact

Molecular phylogenetic and evolutionary analyses of Muar strain of Japanese encephalitis virus reveal it is the missing fifth genotype

2011 ◽  
Vol 11 (5) ◽  
pp. 855-862 ◽  
Author(s):  
Manal A.F. Mohammed ◽  
Sareen E. Galbraith ◽  
Alan D. Radford ◽  
Winifred Dove ◽  
Tomohiko Takasaki ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Molecular Phylogenetic

scholarly journals Emergence of Genotype I of Japanese Encephalitis Virus as the Dominant Genotype in Asia

2011 ◽  
Vol 85 (19) ◽  
pp. 9847-9853 ◽  
Author(s):  
X.-L. Pan ◽  
H. Liu ◽  
H.-Y. Wang ◽  
S.-H. Fu ◽  
H.-Z. Liu ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Genotype I ◽  
Dominant Genotype

The pre membrane and envelope protein is the crucial virulence determinant of Japanese encephalitis virus

2020 ◽  
Vol 148 ◽  
pp. 104492
Author(s):  
Sheng-ling Leng ◽  
Rong Huang ◽  
Ya-nan Feng ◽  
Li-juan Peng ◽  
Jian Yang ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Envelope Protein ◽  
Encephalitis Virus ◽  
Virulence Determinant
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