Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence

2007 ◽  
Vol 19 (4) ◽  
pp. 1147-1160 ◽  
Author(s):  
Maria Nobile ◽  
Roberto Giorda ◽  
Cecilia Marino ◽  
Ombretta Carlet ◽  
Valentina Pastore ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Dopamine Receptor ◽  
Serotonin Transporter ◽  
Promoter Region ◽  
Child Behavior Checklist ◽  
Population Sample ◽  
Aggressive Behaviors ◽  
Rule Breaking ◽  
The Impact ◽  
Dopamine Receptor D4

AbstractThe impact of socioeconomic status (SES) and genetic polymorphisms on individual differences for externalized behaviors have often been investigated separately in studies of children and adults. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 (DRD4) and serotonin transporter linked promoter region (5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6–18. We found evidence, which was based on both one locus and two-loci genotype analyses, that low SES andDRD4long and5-HTTLPRlong alleles, both alone and in interaction, are associated with higher aggressive behavior scores. The effects were similar but more modest and limited to one locus genotype analyses for rule-breaking behavior. Consistent with studies that showed the effects of societal moderators on the heritability of externalized behaviors across different segments of the population, we suggest that diminished social constraints associated with low parental SES may act as enhancers of the genetic influence of specificDRD4and5-HTTLPRalleles over aggressive behaviors in preadolescence.

Evidence for a gene–gene interaction in predicting children's behavior problems: Association of serotonin transporter short and dopamine receptor D4 long genotypes with internalizing and externalizing behaviors in typically developing 7-year-olds

2007 ◽  
Vol 19 (4) ◽  
pp. 1105-1116 ◽  
Author(s):  
Louis A. Schmidt ◽  
Nathan A. Fox ◽  
Dean H. Hamer
Keyword(s):  
Behavior Problems ◽  
Dopamine Receptor ◽  
Serotonin Transporter ◽  
Child Behavior Checklist ◽  
Externalizing Behaviors ◽  
Typically Developing ◽  
Short Allele ◽  
Internalizing And Externalizing Behaviors ◽  
Internalizing And Externalizing ◽  
Dopamine Receptor D4

AbstractRecent work on the molecular genetics of complex traits in typical and atypical human development has focused primarilyon associations of single genes with behavior. Disparate literature suggests that the presence of one or two copies of the short allele of the serotonin transporter (5-HTT) gene and the long allele (7-repeat allele) version of the dopamine receptor D4 (DRD4) gene predicts internalizing- and externalizing-related behaviors, respectively. Apparently for the first time in the extant literature, we report a gene–gene statistical interaction on behavior problems in a group of typically developing children at age 7. DNA was extracted from buccal cells collected from 108 children and genotyped for short and long alleles of the5-HTTgene and the short (2–5 repeats) versus long (6–8 repeats) allele of theDRD4gene. Mothers completed the Child Behavior Checklist. As predicted, children with one or two copies of the short allele of the5-HTTgeneandthe long allele version of theDRD4gene exhibited significantly more internalizing and externalizing behaviors at age 7 than children with other combinations of the5-HTTandDRD4short and long genotypes. As well, children with the5-HTTlongand DRD4long genotypes had the lowest reported scores on internalizing and externalizing behaviors at age 7, suggesting that the presence of the5-HTTlong genotype may serve as a protective factor against these behaviors in children with the longDRD4genotype. Implications of these findings for understanding cumulative biological risk and protective factors in childhood behavior problems and psychopathology are discussed.

Lack of Association Between Down Syndrome and Polymorphisms in Dopamine Receptor D4 and Serotonin Transporter Genes

2008 ◽  
Vol 33 (7) ◽  
pp. 1286-1291 ◽  
Author(s):  
Aneek Das Bhowmik ◽  
Samikshan Dutta ◽  
Swagata Sinha ◽  
Anindita Chattopadhyay ◽  
Kanchan Mukhopadhyay
Keyword(s):  
Down Syndrome ◽  
Dopamine Receptor ◽  
Serotonin Transporter ◽  
Dopamine Receptor D4

Dopamine receptor D4 gene moderates the effect of positive and negative peer experiences on later delinquency: The Tracking Adolescents' Individual Lives Survey study

2013 ◽  
Vol 25 (4pt1) ◽  
pp. 1107-1117 ◽  
Author(s):  
Tina Kretschmer ◽  
Jan Kornelis Dijkstra ◽  
Johan Ormel ◽  
Frank C. Verhulst ◽  
René Veenstra
Keyword(s):  
Dopamine Receptor ◽  
Adolescent Development ◽  
Peer Relations ◽  
Psychosocial Adjustment ◽  
Genetic Factors ◽  
Well Being ◽  
Survey Study ◽  
Peer Experiences ◽  
The Impact ◽  
Dopamine Receptor D4

AbstractThe quality of adolescents' relationships with peers can have a lasting impact on later psychosocial adjustment, mental health, and behavior. However, the effect of peer relations on later problem behavior is not uniformly strong, and genetic factors might influence this association. This study used four-wave longitudinal (11–19 years) data (n = 1,151) from the Tracking Adolescents' Individual Lives Survey, a Dutch cohort study into adolescent development to test whether the dopamine receptor D4 polymorphism moderates the impact of negative (i.e., victimization) and positive peer experiences (i.e., social well-being) on later delinquency. Contrary to our expectations, results showed that carriers of the dopamine receptor D4 gene 4-repeat homozygous variant instead of those carrying the 7-repeat allele were more susceptible to the effects of both peer victimization and social well-being on delinquency later in adolescence. Findings of our study are discussed in light of other studies into genetic moderation of peer effects on adolescent development and the possibility that developmental specifics in adolescence, such as maturation processes in brain structure and functioning, may affect the interplay of environmental and genetic factors in this period in life.

Self-esteem in remitted patients with mood disorders is not associated with the dopamine receptor D4 and the serotonin transporter genes

1998 ◽  
Vol 80 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Alessandro Serretti ◽  
Fabio Macciardi ◽  
Daniela Di Bella ◽  
Marco Catalano ◽  
Enrico Smeraldi
Keyword(s):  
Mood Disorders ◽  
Dopamine Receptor ◽  
Serotonin Transporter ◽  
Self Esteem ◽  
Dopamine Receptor D4

scholarly journals The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants

2015 ◽  
Vol 27 (1) ◽  
pp. 51-67 ◽  
Author(s):  
H. Harrington Cleveland ◽  
Gabriel L. Schlomer ◽  
David J. Vandenbergh ◽  
Mark Feinberg ◽  
Mark Greenberg ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Dopamine Receptor ◽  
Serotonin Transporter ◽  
Sixth Grade ◽  
Ninth Grade ◽  
Polymorphic Region ◽  
Intervention Effects ◽  
Maternal Involvement ◽  
Reduced Drinking ◽  
Dopamine Receptor D4

AbstractData drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4). Variation in this gene and maternal involvement were hypothesized to moderate the influence of intervention status on alcohol use. The PROSPER data used were drawn from 28 communities randomly assigned to intervention or comparison conditions. Participating youth were assessed in five in-home interviews from sixth to ninth grades. A main effect of sixth-grade pretest maternal involvement on ninth-grade alcohol use was found. Neither intervention status nor DRD4 variation was unconditionally linked to ninth-grade drinking. However, moderation analyses revealed a significant three-way interaction among DRD4 status, maternal involvement, and intervention condition. Follow-up analyses revealed that prevention reduced drinking risk, but only for youth with at least one DRD4 seven-repeat allele who reported average or greater pretest levels of maternal involvement. To determine if this conditional pattern was limited to the DRD4 gene, we repeated analyses using the serotonin transporter linked polymorphic region site near the serotonin transporter gene. The results for this supplemental analysis revealed a significant three-way interaction similar but not identical to that found for DRD4.

scholarly journals The impact of tooth loss on cognitive function

2021 ◽  
Author(s):  
Pablo Galindo-Moreno ◽  
Lucia Lopez-Chaichio ◽  
Miguel Padial-Molina ◽  
Gustavo Avila-Ortiz ◽  
Francisco O’Valle ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Tooth Loss ◽  
Multinomial Logistic Regression ◽  
Population Sample ◽  
Cognitive Status ◽  
Anxiety And Depression ◽  
Number Of Teeth ◽  
The Impact

Abstract Objective To investigate if there is epidemiological evidence of an association between edentulism and cognitive decline beside that currently available from limited sample-sized case series and cross-sectional studies considering limited co-variables. Materials and methods Data from two USA national health surveys [NHIS 2014–2017 and NHANES 2005–2018] were analyzed using multinomial logistic regression to study the impact of type of edentulism and number of remaining teeth on memory and concentration problems. Age, gender, socioeconomic status, education level, cardiovascular health index, body mass index, exercise, alcohol, smoking habits, and anxiety and depression were used as covariates. Results The combined population sample was 102,291 individuals. Age, socioeconomic status, educational level, anxiety and depression levels, and edentulism showed the highest odds ratios for cognitive decline. Number of teeth present in the mouth was found to be a predictor of cognitive status. This association showed a gradient effect, so that the lower the number of teeth, the greater the risk of exhibiting cognitive decline. Conclusions Edentulism was found among the higher ORs for cognitive impairment. Clinical relevance Maintenance of functional teeth through the promotion of oral health may contribute to the preservation of memory/concentration and other essential cognitive functions. Thus, increasing and efficiently coordinating efforts aimed at preventing of tooth loss in the adult population could substantially contribute to reduce the incidence of cognitive impairment.

scholarly journals Catechol-O-methyltransferase and dopamine receptor D4 gene variants: Possible association with substance abuse in Bangladeshi male

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246462
Author(s):  
Jahanara Akter Sonia ◽  
Tohfa Kabir ◽  
M. M. Towhidul Islam ◽  
Yearul Kabir
Keyword(s):  
Substance Abuse ◽  
Dopamine Receptor ◽  
Tandem Duplication ◽  
Age Of Onset ◽  
Extended Period ◽  
Significant Difference ◽  
Comt Polymorphism ◽  
The Impact ◽  
Drug Habit ◽  
Dopamine Receptor D4

Genetic risk of substance abuse is encoded mainly by central neurochemical pathways(mostly dopaminergic system) related to reinforcement and reward. In this study a functionalpolymorphism in Catechol-O-methyltransferase (COMT) (Val158Met) and the Dopamine receptor D4 gene (DRD4) (120 bp tandem duplication) has been studied in substance abused subjects. The study was carried out with 183 substance abused subjects and 175 healthy persons with no history of substance abuse. DNA was extracted and polymorphisms were analyzed using allele-specific PCR. The impact of these two polymorphisms was also analyzed on addictive characteristics (age of starting abuse, a pattern of drug habit, and period of addiction). It was found that only the heterozygous variant of COMT polymorphism (Val/Met) (p<0.05, OR = 1.66, 95% CI = 1.044–2.658) and both homozygous (p<0.05, OR = 0.43, 95% CI = 0.193–0.937) and heterozygous (p<0.05, OR = 0.37, 95% CI = 0.172–0.826) derived variants of DRD4 120 bp tandem duplication were significantly associated with risk of substance abuse compared to controls. In case of association of these polymorphisms with an age of onset, no significant difference was found among three different genotypic groups of COMT polymorphism. Whereas, the homozygous derived variant (240 bp/240 bp) of DRD4 gene was found to have a later age of onset (20.5±0.8) for substance abuse compared to heterozygous (120 bp/240 bp) (19.1±0.8) and wild type homozygous variant (120 bp/120 bp) (16.0±0.5), which was statistically significant (p<0.05). Again, in the case of the pattern of drug habit, the frequency of the Val/Val genotype is higher in polysubstance abused (>2 drugs) subjects (p<0.05) compared to the heterozygous Val/Met containing variants. An association of period of addiction was analyzed with an individual type of substance abuse and found that heroin abused subjects have a significantly higher period of addiction (11.6±1.0) compared to other abusers (p<0.01). Further, it was found that Met/Met containing variants of COMT polymorphism has a more extended period of addiction than other genetic variants in heroin abused subjects. These results indicate that genetic variability may influence the susceptibility to the risk of substance abuse and addictive characteristics.

scholarly journals Is serotonin transporter genotype associated with epigenetic susceptibility or vulnerability? Examination of the impact of socioeconomic status risk on African American youth

2014 ◽  
Vol 26 (2) ◽  
pp. 289-304 ◽  
Author(s):  
Steven R. H. Beach ◽  
Gene H. Brody ◽  
Man Kit Lei ◽  
Sangjin Kim ◽  
Juan Cui ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
African American ◽  
Serotonin Transporter ◽  
African American Youth ◽  
Differential Susceptibility ◽  
Parent Report ◽  
Short Allele ◽  
Serotonin Transporter Genotype ◽  
The Impact ◽  
Best Fit

AbstractWe hypothesized that presence of the short allele in the promoter region of the serotonin transporter would moderate the effect of early cumulative socioeconomic status (SES) risk on epigenetic change among African American youth. Contrasting hypotheses regarding the shape of the interaction effect were generated using vulnerability and susceptibility frameworks and applied to data from a sample of 388 African American youth. Early cumulative SES risk assessed at 11–13 years based on parent report interacted with presence of the short allele to predict differential methylation assessed at age 19. Across multiple tests, a differential susceptibility perspective rather than a diathesis–stress framework best fit the data for genes associated with depression, consistently demonstrating greater epigenetic response to early cumulative SES risk among short allele carriers. A pattern consistent with greater impact among short allele carriers also was observed using all cytosine nucleotide–phosphate–guanine nucleotide sites across the genome that were differentially affected by early cumulative SES risk. We conclude that the short allele is associated with increased responsiveness to early cumulative SES risk among African American youth, leading to epigenetic divergence for depression-related genes in response to exposure to heightened SES risk among short allele carriers in a “for better” or “for worse” pattern.

scholarly journals A-059 Gender-Related Behavioral Differences in Children with Partial or Complete Agenesis of the Corpus Callosum: Exploring Attention, Rule Breaking, and Aggressive Behaviors

2020 ◽  
Vol 35 (6) ◽  
pp. 849-849
Author(s):  
Rich-Wimmer N ◽  
Tanios R ◽  
Qu Y ◽  
Andrews G
Keyword(s):  
Corpus Callosum ◽  
Social Interactions ◽  
Child Behavior Checklist ◽  
Attention Problems ◽  
Cerebral Hemispheres ◽  
Care Providers ◽  
Aggressive Behaviors ◽  
Behavioral Differences ◽  
Rule Breaking ◽  
Over Time

Abstract Objective Gender-related connectivity differences result from variability in structure of the corpus callosum in children 8 years and up (Ingalhalikar et al., 2014). However, children with complete or partial agenesis of the corpus callosum (ACC) exhibit structural differences that disrupt the connectivity of cerebral hemispheres, causing behavioral challenges (Young et al., 2019). We explored the relationship of behavioral differences across genders, partial and complete ACC diagnoses, and age. Method Initial data included the completed Child Behavior Checklist (CBCL) provided by care-providers (ages 2 to 17) diagnosed with ACC. Follow-up data was obtained four-years later from the original sample (n = 29), which included 20 males (12 complete, 8 partial) and 9 females (5 complete, 4 partial). Results A repeated measures MANOVA was conducted with attention problems, rule-breaking, and aggressive behavior for gender, age, and diagnosis (i.e., partial or complete ACC). A significant interaction diagnosis by gender interaction over time was found for each dependent variable. Conclusion Results indicate females with partial ACC exhibit worsening attention problems with age, while males with partial ACC decrease over time. Complex social interactions among females pose greater challenges due to difficulties integrating information between cerebral hemispheres. Additionally, females are at higher risk of developing internalizing problems (Eaton et al., 2012) when navigating social interactions. Nevertheless, females with partial ACC exhibited significant reductions in aggressive behaviors over time. This perhaps resulted from lower social tolerance of aggressiveness in females, as well as expectations of compliance and obedience. Consequently, mood-related difficulties decrease executive functioning skills, specifically attention and concentration (APA, 2013).

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