Successful treatment of neonatal pulmonary thrombosis in congenital nephrotic syndrome

2012 ◽  
Vol 23 (2) ◽  
pp. 271-273 ◽  
Author(s):  
Krit Makonkawkeyoon ◽  
Suchaya Silvilairat ◽  
Wattana Chartapisak
Keyword(s):  
Nephrotic Syndrome ◽  
Congenital Nephrotic Syndrome ◽  
Venous Catheter ◽  
Tissue Type ◽  
Successful Management ◽  
Central Venous ◽  
Artery Thrombosis ◽  
Type Plasminogen Activator ◽  
Threatening Condition ◽  
Life Threatening

AbstractThe incidence of neonatal thrombosis has been increasing in recent times because of the use of a central venous catheter. A treatment modality consisting of fibrinolytic agents has been administered for this life-threatening condition. This case report presents the successful management of a pulmonary artery thrombosis with a recombinant tissue-type plasminogen activator in a patient with neonatal congenital nephrotic syndrome.

Function of Tissue-type Plasminogen Activator Releaser on Vascular Endothelial Cells and Thrombolysis In Vivo

2002 ◽  
Vol 87 (06) ◽  
pp. 1069-1074 ◽  
Author(s):  
Hiroyuki Matsuno ◽  
Mikio Hayashi ◽  
Koji Horibuchi ◽  
Kiyotaka Okada ◽  
Hideharu Fukao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Tissue Type ◽  
Vascular Endothelial ◽  
Thrombosis Model ◽  
Artery Thrombosis ◽  
Type Plasminogen Activator ◽  
Thrombolytic Effect ◽  
Dose Dependent

SummaryThe effect of monosodium[2-(6-hydroxynaphthalen-2-yl)-6-methylpyrimidin-4-yloxy]acetate dihydrate (JTV-926) on fibrinolysis was investigated in vitro and in vivo. JTV-926 released tissue-type plasminogen activator (t-PA) from human vascular endothelial cells in a dose-dependent manner. The thrombolytic effect of JTV-926 was studied using three animal thrombosis models; a photo-irradiation-induced mouse carotid artery thrombosis model, a photo-irradiation-induced rat femoral artery thrombosis model and a thrombin-induced rat venous thrombosis model. In the mouse thrombosis model, t-PA deficient mice (t-PA−/−mice) and their wild-type (t-PA+/+) were used. JTV-926 was injected as a bolus 30 min after the interruption of blood flow by an occlusion thrombi. Blood flow was continuously monitored for 180 min after intravenous administration of JTV-926 (1 mg/kg). Although the recanalization rate of the occluded artery was 37.5% in t-PA +/+ mice with the vehicle control, it increased to 75% in t-PA+/+ mice after JTV-926 administration. However, when JTV-926 was administrated in t-PA−/−mice, vascular recanalization was not observed in any arteries. In the photo-irradiation-induced rat femoral artery thrombosis model, intra-duodenal administration of JTV-926 induced thrombolysis. Moreover, in the thrombin-induced rat venous thrombosis model, the dose-dependent thrombolysis was also observed by oral administration of JTV-926. It was suggested that JTV-926 revealed a sufficient thrombolytic effect through the absorption from the intestine. Thus, a newly synthesized compound, JTV-926 induced t-PA release from vascular endothelial cells and effective thrombolysis in vivo.

Central Venous Catheter Securement: Using the Healthcare and Technology Synergy Model to Take a Closer Look

2015 ◽  
Vol 20 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Denise Macklin ◽  
Paul L. Blackburn
Keyword(s):  
Central Venous Catheter ◽  
Health Care Providers ◽  
Venous Catheter ◽  
Clinical Settings ◽  
Care Providers ◽  
Central Venous ◽  
Bacterial Migration ◽  
Life Threatening ◽  
Delay Of Treatment ◽  
Catheter Replacement

Abstract Proper securement provides a safe vascular access device environment for both patients and health care providers. Successful securement protects central venous catheters from several sources of failure until the end of therapy by preventing central venous catheter movement during all phases of care. Movement causes vein trauma, bacterial migration, distal tip location variation, loss of dressing integrity, and even total dislodgement. Any of these events can have serious consequences, including catheter-related bloodstream infection, thrombosis, delay of treatment, catheter replacement, and potential hemorrhage, all of which can be life-threatening events, and increase costs. We review patient issues, practice issues, and the types of securement currently used in clinical settings.

scholarly journals Inadvertent Insertion of Hemodialysis Catheter into Brachiocephalic Trunk During Cannulation of Internal Jugular Vein: Management Strategies

2022 ◽  
Author(s):  
Chinmaya Nanda ◽  
Vinit Garg ◽  
Ajmer Singh ◽  
Yatin Mehta
Keyword(s):  
Intensive Care Unit ◽  
Jugular Vein ◽  
Management Strategies ◽  
Venous Catheter ◽  
Central Venous Catheter Insertion ◽  
Endovascular Technique ◽  
Central Venous ◽  
Hemodialysis Catheter ◽  
Brachiocephalic Trunk ◽  
Life Threatening

AbstractCentral venous catheter insertion is a commonly performed procedure in the operating room and intensive care unit. It is associated with many complications, some of which may be life-threatening. We report here an accidental insertion of a hemodialysis catheter into the brachiocephalic trunk, which was successfully removed by an endovascular technique.

Life-Threatening Mediastinal Hematoma Caused by Extravascular Infusion Through a Triple-Lumen Central Venous Catheter

2004 ◽  
Vol 99 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Matthias Hohlrieder ◽  
Rosmarie Oberhammer ◽  
Ingo H. Lorenz ◽  
Josef Margreiter ◽  
Gabriele Kühbacher ◽  
...  
Keyword(s):  
Central Venous Catheter ◽  
Venous Catheter ◽  
Central Venous ◽  
Mediastinal Hematoma ◽  
Life Threatening
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