Severe hypertriglyceridemia associated with everolimus drug-eluting stent placement in an infant

2019 ◽  
Vol 29 (4) ◽  
pp. 541-543 ◽  
Author(s):  
Kuan-Chi Lai ◽  
Julie A. Brothers ◽  
Jason Z. Stoller

AbstractWe report a case of severe hypertriglyceridemia associated with an everolimus drug-eluting stent in an infant with pulmonary vein stenosis. We review from current literature the mechanisms by which everolimus may cause dyslipidaemia, pharmacokinetics of everolimus in drug-eluting stents, and treatments of hypertriglyceridemia. This case demonstrates the need to closely monitor serum triglyceride levels after everolimus drug-eluting stent placement in infants.

2019 ◽  
Vol 29 (8) ◽  
pp. 1057-1065 ◽  
Author(s):  
Yoshihiko Kurita ◽  
Kenji Baba ◽  
Maiko Kondo ◽  
Takahiro Eitoku ◽  
Shingo Kasahara ◽  
...  

AbstractBackground:Pulmonary vein stenosis (PVS) is a condition with challenging treatment and leads to severe cardiac failure and pulmonary hypertension. Despite aggressive surgical or catheter-based intervention, the prognosis of PVS is unsatisfactory. This study aimed to assess the prognosis and to establish appropriate treatment strategies.Methods:We retrospectively reviewed endovascular treatments for PVS (2001–2017) from the clinical database at the Okayama University Hospital.Results:A total of 24 patients underwent PVS associated with total anomalous pulmonary venous connection and 7 patients underwent isolated congenital PVS. In total, 53 stenotic pulmonary veins were subjected to endovascular treatments; 40 of them were stented by hybrid (29) and percutaneous procedures (11) (bare-metal stent, n = 34; drug-eluting stent, n = 9). Stent size of hybrid stenting was larger than percutaneous stenting. Median follow-up duration from the onset of PVS was 24 months (4–134 months). Survival rate was 71 and 49% at 1 and 5 years, respectively. There was no statistically significant difference between stent placement and survival; however, patients who underwent bare-metal stent implantation had statistically better survival than those who underwent drug-eluting stent implantation or balloon angioplasty. Early onset of stenosis, timing of stenting, and small vessel diameter of pulmonary vein before stenting were considered as risk factors for in-stent restenosis. Freedom from re-intervention was 50 and 26% at 1 and 2 years.Conclusions:To improve survival and stent patency, implantation of large stent is important. However, re-intervention after stenting is also significant to obtain good outcome.


EP Europace ◽  
2010 ◽  
Vol 13 (1) ◽  
pp. 57-61 ◽  
Author(s):  
T. J. R. De Potter ◽  
B. Schmidt ◽  
K. R. J. Chun ◽  
C. Schneider ◽  
R. Malisius ◽  
...  

2011 ◽  
Vol 57 (14) ◽  
pp. E2007
Author(s):  
Sowmya Balasubramanian ◽  
Audrey C. Marshall ◽  
Lynn F. Peng ◽  
James E. Lock ◽  
Doff B. McElhinney

2017 ◽  
Vol 13 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Jason F. Goldberg ◽  
Craig L. Jensen ◽  
Rajesh Krishnamurthy ◽  
Nidhy P. Varghese ◽  
Henri Justino

2015 ◽  
Vol 179 ◽  
pp. 13-15
Author(s):  
Maksymilian Mielczarek ◽  
Dariusz Ciecwierz ◽  
Robert Sabiniewicz ◽  
Anna Kochanska ◽  
Justyna Suchecka ◽  
...  

2021 ◽  
pp. 1-3
Author(s):  
Hiroaki Kise ◽  
Takanari Fujii ◽  
Hideshi Tomita

Abstract Although larger stent placement could be effective for pulmonary vein stenosis, stents extrusion tends to occur due to caliber narrowing, small landing area, and the slippery nature. We placed stents with diameter ≧8 mm for four stenotic lesions using the “half-uncovered technique”. All stents were precisely placed and successfully resolved the stenosis. This technique allows us to avoid extrusion and to perform safe and effective dilatation when placing larger stents for pulmonary vein stenosis.


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