Working memory and processing speed deficits in systemic lupus erythematosus as measured by the paced auditory serial addition test

2004 ◽  
Vol 10 (01) ◽  
Author(s):  
JANET L. SHUCARD ◽  
JOY PARRISH ◽  
DAVID W. SHUCARD ◽  
DANIELLE C. McCABE ◽  
RALPH H.B. BENEDICT ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Working Memory ◽  
Processing Speed ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Serial Addition

scholarly journals White Matter Abnormalities and Working Memory Impairment in Systemic Lupus Erythematosus

2013 ◽  
Vol 26 (2) ◽  
pp. 63-72 ◽  
Author(s):  
Elizabeth Kozora ◽  
David B. Arciniegas ◽  
Emily Duggan ◽  
Sterling West ◽  
Mark S. Brown ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Working Memory ◽  
White Matter ◽  
Lupus Erythematosus ◽  
Memory Impairment ◽  
Systemic Lupus ◽  
White Matter Abnormalities

Cognitive Dysfunction and White Matter Abnormalities in Systemic Lupus Erythematosus

2011 ◽  
Vol 17 (3) ◽  
pp. 385-392 ◽  
Author(s):  
Elizabeth Kozora ◽  
Christopher M. Filley
Keyword(s):  
Systemic Lupus Erythematosus ◽  
White Matter ◽  
Cognitive Dysfunction ◽  
Processing Speed ◽  
Lupus Erythematosus ◽  
Neuronal Damage ◽  
Cerebral Atrophy ◽  
Periventricular White Matter ◽  
Systemic Lupus ◽  
Neuroimaging Techniques

AbstractBrain abnormalities have been documented by neuropsychological assessment as well as a variety of neuroimaging techniques in patients with systemic lupus erythematosus (SLE). Conventional neuroimaging in patients with neuropsychiatric disease (NPSLE) typically discloses periventricular white matter (WM) hyperintensities, infarcts, hemorrhages, and cerebral atrophy. In SLE patients with none of these findings, sophisticated neuroimaging techniques have recently supported associations between microstructural WM abnormalities and abnormal attention, executive function, and processing speed. This mild cognitive dysfunction in SLE (MCD-SLE), which may result from early myelinopathy, precedes the more severe cognitive dysfunction of NPSLE, related to more obvious WM and neuronal damage. (JINS, 2011, 17, 385–392)

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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