The relationship between processing speed and working memory demand in systemic lupus erythematosus: Evidence from a visual n-back task.

We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulability were investigated in patients with SLE by measuring thrombomodulin (TM), D-dimer (DDi) and thrombin generation (TG) potential. A total of 90 participants were distributed into three groups: 1) women with SLE presenting with low disease activity (laSLE) (SLEDAI-2K ≤ 4), 2) women with SLE presenting with moderate to high disease activity (mhaSLE) (SLEDAI-2K > 4), and 3) a control group comprising healthy women. Levels of TM and DDi were higher both in the laSLE and mhaSLE groups compared to controls and in mhaSLE compared to the laSLE group. With respect to TG assay, lagtime and endogen thrombin potential, low concentrations of tissue factor provided the best results for discrimination among groups. Analysis of these data allow us to conclude that TM, DDi and TG are potentially useful markers for discriminating patients with very active from those with lower active disease. Higher SLE activity may cause endothelial injury, resulting in higher TG and consequently a hypercoagulability state underlying the picture of thrombosis common in this inflammatory disease.

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Functional Magnetic Resonance Imaging of Working Memory and Executive Dysfunction in Systemic Lupus Erythematosus and Antiphospholipid Antibody-Positive Patients

Arthritis Care & Research ◽

10.1002/acr.22873 ◽

2016 ◽

Vol 68 (11) ◽

pp. 1655-1663 ◽

Cited By ~ 12

Author(s):

E. Kozora ◽

A. M. Uluğ ◽

D. Erkan ◽

A. Vo ◽

C. M. Filley ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Systemic Lupus Erythematosus ◽

Working Memory ◽

Magnetic Resonance ◽

Lupus Erythematosus ◽

Executive Dysfunction ◽

Antiphospholipid Antibody ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Systemic Lupus

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Serum Levels of MDC and MMP-9 and the Relationship Between Serum Levels and Disease Activity in the Patients with Systemic Lupus Erythematosus

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.314.7325 ◽

1969 ◽

Vol 31 (4) ◽

Cited By ~ 1

Author(s):

Yang Liu ◽

Tie Ning ◽

Li-Jie Bai

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Serum Levels ◽

Systemic Lupus ◽

The Relationship

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The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus

Journal of the International Neuropsychological Society ◽

10.1017/s1355617797003779 ◽

1997 ◽

Vol 3 (4) ◽

pp. 377-386 ◽

Cited By ~ 101

Author(s):

SUSAN D. DENBURG ◽

RAMONA M. CARBOTTE ◽

JEFFREY S. GINSBERG ◽

JUDAH A. DENBURG

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Verbal Memory ◽

Lupus Anticoagulant ◽

Cognitive Test ◽

Antiphospholipid Antibody ◽

Systemic Lupus ◽

Cross Sectional ◽

Antibody Positivity ◽

The Relationship

Objective: To examine the relationship between antiphospholipid antibody positivity (expressed as the lupus anticoagulant) and cognitive dysfunction in patients with systemic lupus erythematosus (SLE). Methods: Cross-sectional comparisons of lupus anticoagulant (LA) positive (N = 39) and negative (N = 79) patients and controls (N = 35) on a cognitive test battery; 22 LA-positive and 53 LA-negative patients who had never experienced neuropsychiatric events (never-NP–SLE) were also compared separately. Results: LA-positive patients were 2 to 3 times more likely than were LA-negative patients to be designated as cognitively impaired. As a group, LA-positive patients, particularly those in the never-NP–SLE group, demonstrated lower performance primarily on tasks of verbal memory, cognitive flexibility, and psychomotor speed. Conclusions: LA positivity is associated with subclinical nervous system compromise, and a pattern of deficits compatible with subcortical involvement, possibly on the basis of ongoing LA-related microthrombotic events or vasculopathy. (JINS, 1997, 3, 377–386.)

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SYSTEMIC LUPUS ERYTHEMATOSUS AND SYNDROMES POSSIBLY RELATED

PEDIATRICS ◽

10.1542/peds.19.6.1109 ◽

1957 ◽

Vol 19 (6) ◽

pp. 1109-1123

Author(s):

M. A. Ogryzlo ◽

H. A. Smythe

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Serum Proteins ◽

Clinical Manifestations ◽

Electrophoretic Pattern ◽

Chemotherapeutic Agents ◽

Systemic Lupus ◽

Relationship Of ◽

The Relationship

Attention is drawn to the difficulties that may be encountered in the positive identification and classification of many patients suspected of suffering from systemic lupus erythematosus. Much of this is due to a lack of specific criteria, either clinical or pathologic, for the diagnosis of the disease. The problem has been made more difficult by the recognition of a number of other syndromes that bear a superficial resemblance to systemic lupus erythematosus, yet differ in clinical manifestations, natural course, prognosis and other respects. A feature common to the group is the presence of the L.E. cell phenomenon. The related conditions differ from lupus enythematosus in that the L.E. phenomenon may only be demonstrable intermittently especially during severe exacerbations of the disease, while at the same time disturbances in the electrophoretic pattern of the serum proteins may be much more profound. In systemic rheumatoid disease the prognosis without steroid therapy is better than in systemic lupus erythematosus, although the morbidity may be great. The reactions which follow administration of certain chemotherapeutic agents are of considerable interest, particularly in view of the similarity to lupus erythematosus and rheumatoid arthritis, and the reversibility on withdrawal of the offending agent. The relationship of these syndromes to each other and to classical systemic lupus erythematosus has not yet been resolved, and inclusion of them under the diagnosis of systemic lupus erythematosus at this time must be regarded as premature.

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