Sample Depletion of the Matrix-Assisted Laser Desorption Process Monitored Using Radionuclide Detection

2002 ◽  
Vol 74 (24) ◽  
pp. 6200-6204 ◽  
Author(s):  
Jason S. Page ◽  
Jonathan V. Sweedler
Keyword(s):  
Laser Desorption ◽  
Desorption Process ◽  
Radionuclide Detection ◽  
The Matrix ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

scholarly journals Cyanocobalamin conjugates of cisplatin and diaminocyclohexane-platinum(ii): matrix-assisted laser desorption ionization mass spectrometry characterization using 4-chloro-α-cyanocinnamic acid as the matrix

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53658-53666 ◽  
Author(s):  
G. Ventura ◽  
F. Arnesano ◽  
C. D. Calvano ◽  
F. Palmisano ◽  
T. R. I. Cataldi
Keyword(s):  
Mass Spectrometry ◽  
Chemotherapeutic Agent ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Malignant Tumours ◽  
Desorption Ionization ◽  
The Matrix ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

cis-Diamminedichloroplatinum(ii), also known as cisplatin, is a widely used chemotherapeutic agent to treat several malignant tumours, but unfortunately it causes serious side effects, especially nausea, vomiting and nephrotoxicity.

Wavelength- and Time-Resolved Luminescence Spectroscopy for Investigation of the Matrix-Assisted Laser Desorption Process

2002 ◽  
Vol 8 (4) ◽  
pp. 287-293 ◽  
Author(s):  
Carsten Zechmann ◽  
Tassilo Muskat ◽  
Jürgen Grotemeyer
Keyword(s):  
Ionization Energy ◽  
Stokes Shift ◽  
Laser Desorption ◽  
Luminescence Spectroscopy ◽  
Time Resolved ◽  
Fluorescence Measurements ◽  
The Matrix ◽  
Stokes Shifts ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

This work deals with investigations of fluorescence phenomena during interaction of ultraviolet laser radiation with four substances (2,5-dihydroxybenzoic acid, 3-hydroxypicolinic acid, dithranol and ferulic acid) commonly used as matrices in matrix-assisted laser desorption/ionization (MALDI). Wavelength-resolved fluorescence measurements allowed classification of UV-MALDI matrices on the basis of their Stokes shift. Matrices showing a high Stokes shift dissipated high amounts of laser energy by means of intra- and intermolecular energy transfer processes, hence contributing less to the ionization of analyte compounds. Conversely, matrix substances with a low Stokes shift retained more of the original photonic energy which may then be available for ionization within the matrix or after desorption of molecular species. Therefore matrix compounds can be designated as “hard” (high ionization energy) in the case of small Stokes shifts or “soft” (low ionization energy) in the case of high Stokes shifts. Time-resolved measurements showed fluorescence lifetimes below 5 ns for all four substances.

Sign in / Sign up

Export Citation Format

Share Document