Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties

Analytical Chemistry ◽

10.1021/ac403173p ◽

2013 ◽

Vol 85 (23) ◽

pp. 11185-11188 ◽

Author(s):

Xiangguo (Eric) Shi ◽

Thomas E. Wales ◽

Carl Elkin ◽

Noriyuki Kawahata ◽

John R. Engen ◽

...

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Conformational Dynamics ◽

Stapled Peptide ◽

Exchange Mass Spectrometry ◽

Pharmacokinetic Properties ◽

Hydrogen Exchange Mass Spectrometry

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Monitoring the Folding Pathway of a Protein Over Evolutionary Time using Hydrogen Exchange - Mass Spectrometry (HX-MS)

Biophysical Journal ◽

10.1016/j.bpj.2017.11.350 ◽

2018 ◽

Vol 114 (3) ◽

pp. 54a

Author(s):

Eric Bolin ◽

Shion Lim ◽

Susan Marqusee

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Folding Pathway ◽

Evolutionary Time ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Structural Differences in Aβ Amyloid Protofibrils and Fibrils Mapped by Hydrogen Exchange – Mass Spectrometry with On-line Proteolytic Fragmentation

Journal of Molecular Biology ◽

10.1016/j.jmb.2006.06.066 ◽

2006 ◽

Vol 361 (4) ◽

pp. 785-795 ◽

Author(s):

Indu Kheterpal ◽

Maolian Chen ◽

Kelsey D. Cook ◽

Ronald Wetzel

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Aβ Amyloid ◽

Structural Differences ◽

Hydrogen Exchange Mass Spectrometry ◽

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Label-Free, In-Solution Screening of Peptide Libraries for Binding to Protein Targets Using Hydrogen Exchange Mass Spectrometry

Journal of the American Chemical Society ◽

10.1021/jacs.5b11742 ◽

2016 ◽

Vol 138 (4) ◽

pp. 1335-1343 ◽

Author(s):

Walid S. Maaty ◽

David D. Weis

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Peptide Libraries ◽

Protein Targets ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

mAbs ◽

10.1080/19420862.2015.1029217 ◽

2015 ◽

Vol 7 (3) ◽

pp. 525-539 ◽

Author(s):

Jayant Arora ◽

John M Hickey ◽

Ranajoy Majumdar ◽

Reza Esfandiary ◽

Steven M Bishop ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Hydrogen Exchange ◽

Dynamic Coupling ◽

Coupling Effects ◽

Exchange Mass Spectrometry ◽

Protein Interfaces ◽

Igg1 Monoclonal Antibody ◽

Hydrogen Exchange Mass Spectrometry ◽

Self Association

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Applying Hydrogen Exchange Mass Spectrometry Coupled with Numerical Simulations to Investigate Toxic Misfolding of β2-Microglobulin

Biophysical Journal ◽

10.1016/j.bpj.2018.11.2556 ◽

2019 ◽

Vol 116 (3) ◽

pp. 473a

Author(s):

Angelika Hirsch ◽

John Strahan ◽

Amy Wagaman ◽

Sheila Jaswal

Keyword(s):

Mass Spectrometry ◽

Numerical Simulations ◽

Hydrogen Exchange ◽

Β2 Microglobulin ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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ChemInform Abstract: Hydrogen Exchange Mass Spectrometry for Studying Protein Structure and Dynamics

10.1002/chin.201123278 ◽

2011 ◽

Vol 42 (23) ◽

pp. no-no

Author(s):

Lars Konermann ◽

Jingxi Pan ◽

Yu-Hong Liu

Keyword(s):

Mass Spectrometry ◽

Protein Structure ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Structure And Dynamics ◽

Hydrogen Exchange Mass Spectrometry ◽

Protein Structure And Dynamics

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Probing Protein Structure and Dynamics by Hydrogen Exchange–Mass Spectrometry

Current Protocols in Protein Science ◽

10.1002/0471140864.ps1706s28 ◽

2002 ◽

Vol 28 (1) ◽

Author(s):

Lintao Wang ◽

David L. Smith

Keyword(s):

Mass Spectrometry ◽

Protein Structure ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Structure And Dynamics ◽

Hydrogen Exchange Mass Spectrometry ◽

Protein Structure And Dynamics

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Hydrogen Exchange Mass Spectrometry for Conformational Analysis of Proteins

Encyclopedia of Analytical Chemistry ◽

10.1002/9780470027318.a9201 ◽

2011 ◽

Author(s):

John R. Engen ◽

Thomas E. Wales ◽

Xiaomeng Shi

Keyword(s):

Mass Spectrometry ◽

Conformational Analysis ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Rapid Prediction of Deamidation Rates of Proteins to Assess Their Long-Term Stability Using Hydrogen Exchange–Mass Spectrometry

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2019.01.019 ◽

2019 ◽

Vol 108 (6) ◽

pp. 1964-1972 ◽

Author(s):

Chamalee L.D. Gamage ◽

Tyler S. Hageman ◽

David D. Weis

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Term Stability ◽

Exchange Mass Spectrometry ◽

Long Term Stability ◽

Rapid Prediction ◽

Hydrogen Exchange Mass Spectrometry

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Correction to Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements

Analytical Chemistry ◽

10.1021/acs.analchem.7b04690 ◽

2017 ◽

Vol 89 (24) ◽

pp. 13673-13673 ◽

Author(s):

Ronald T. Toth ◽

Brittney J. Mills ◽

Sangeeta B. Joshi ◽

Reza Esfandiary ◽

Steven M. Bishop ◽

...

Keyword(s):

Mass Spectrometry ◽

Exchange Rates ◽

Hydrogen Exchange ◽

Chemical Exchange ◽

Exchange Mass Spectrometry ◽

Empirical Correction ◽

Hydrogen Exchange Mass Spectrometry

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