Iron-, Cobalt-, and Nickel-Catalyzed Asymmetric Transfer Hydrogenation and Asymmetric Hydrogenation of Ketones

2015 ◽  
Vol 48 (9) ◽  
pp. 2587-2598 ◽  
Author(s):  
Yan-Yun Li ◽  
Shen-Luan Yu ◽  
Wei-Yi Shen ◽  
Jing-Xing Gao
Keyword(s):  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Iron Cobalt ◽  
Cobalt And Nickel

scholarly journals Nickel-catalyzed asymmetric transfer hydrogenation of conjugated olefins

2015 ◽  
Vol 51 (60) ◽  
pp. 12115-12117 ◽  
Author(s):  
Siyu Guo ◽  
Peng Yang ◽  
Jianrong (Steve) Zhou
Keyword(s):  
Formic Acid ◽  
Nickel Catalyst ◽  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

A nickel catalyst is used for asymmetric hydrogenation of electron-deficient olefins using formic acid as hydrogen source.

Asymmetric Hydrogenation of Trifluoromethyl Ketones: Application in the Synthesis of Odanacatib and LX-1031

2021 ◽  
Author(s):  
Tiao-Zhen Zhu ◽  
Pan-Lin Shao ◽  
Xumu Zhang
Keyword(s):  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Tridentate Ligands ◽  
Iridium Catalysis ◽  
Trifluoromethyl Ketones ◽  
Stereoelectronic Properties

Due to their stereoelectronic properties, trifluoromethyl (or perfluoroalkyl) ketones are challenging substrates in asymmetric (transfer) hydrogenation. We developed iridium catalysis bearing ferrocene-based tridentate ligands (f-amphol or f-ampha), offering a promising...

Asymmetric hydrogenation and transfer hydrogenation in the enantioselective synthesis of flavonoids

2022 ◽  
Author(s):  
Guilherme S Caleffi ◽  
Felipe C Demidoff ◽  
Carmen Najera ◽  
Paulo Roberto Ribeiro Costa
Keyword(s):  
Asymmetric Hydrogenation ◽  
Enantioselective Synthesis ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Compounds ◽  
Synthetic Methodologies

Asymmetric hydrogenation (AH) and asymmetric transfer hydrogenation (ATH) are versatile synthetic methodologies widely employed in the preparation of chiral compounds. In this review, we explore the applications of AH and...

scholarly journals Design of Iridium N-Heterocyclic Carbene Amino Acid Catalysts for Asymmetric Transfer Hydrogenation of Aryl Ketones

Catalysts ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 671
Author(s):  
Chad M. Bernier ◽  
Joseph S. Merola
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Enantiomeric Excess ◽  
Transfer Hydrogenation ◽  
Acid Catalysts ◽  
Asymmetric Transfer Hydrogenation ◽  
Reaction Conditions ◽  
Chiral Complexes ◽  
Acetophenone Derivatives ◽  
Aryl Ketones

A series of chiral complexes of the form Ir(NHC)2(aa)(H)(X) (NHC = N-heterocyclic carbene, aa = chelated amino acid, X = halide) was synthesized by oxidative addition of -amino acids to iridium(I) bis-NHC compounds and screened for asymmetric transfer hydrogenation of ketones. Following optimization of the reaction conditions, NHC, and amino acid ligands, high enantioselectivity was achieved when employing the Ir(IMe)2(l-Pro)(H)(I) catalyst (IMe = 1,3-dimethylimidazol-2-ylidene), which asymmetrically reduces a range of acetophenone derivatives in up to 95% enantiomeric excess.

Enantioselectivity in the Noyori–Ikariya Asymmetric Transfer Hydrogenation of Ketones

2021 ◽  
Author(s):  
Pavel A. Dub ◽  
Nikolay V. Tkachenko ◽  
Vijyesh K. Vyas ◽  
Martin Wills ◽  
Justin S. Smith ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

Dendritic catalysts for asymmetric transfer hydrogenation based (1S,2R)-norephedrine derived ligands

2003 ◽  
Vol 14 (16) ◽  
pp. 2481-2485 ◽  
Author(s):  
Pei Nian Liu ◽  
Ying Chun Chen ◽  
Xue Qiang Li ◽  
Yong Qiang Tu ◽  
Jin Gen Deng
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation
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