Application of Hydrogen/Deuterium Exchange-Mass Spectrometry to Biopharmaceutical Development Requirements: Improved Sensitivity to Detection of Conformational Changes

Hydrogen Deuterium ◽

Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry

Current Opinion in Structural Biology ◽

10.1016/j.sbi.2019.06.007 ◽

2019 ◽

Vol 58 ◽

pp. 305-313 ◽

Cited By ~ 11

Author(s):

Jie Zheng ◽

Timothy Strutzenberg ◽

Bruce D Pascal ◽

Patrick R Griffin

Keyword(s):

Mass Spectrometry ◽

Protein Dynamics ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Ligand‐induced Conformational Changes in the Acetylcholine Binding Protein Analyzed by Hydrogen‐Deuterium Exchange Mass Spectrometry

The FASEB Journal ◽

10.1096/fasebj.20.4.a244-a ◽

2006 ◽

Vol 20 (4) ◽

Author(s):

Jianxin Shi ◽

Elizabeth A. Komives ◽

Palmer Taylor

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Binding Protein ◽

Deuterium Exchange ◽

Acetylcholine Binding Protein ◽

Hydrogen Deuterium ◽

Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange–Mass Spectrometry

Biochemistry ◽

10.1021/acs.biochem.6b01220 ◽

2017 ◽

Vol 56 (21) ◽

pp. 2676-2689 ◽

Cited By ~ 4

Author(s):

Sharlyn J. Mazur ◽

Elyssia S. Gallagher ◽

Subrata Debnath ◽

Stewart R. Durell ◽

Kyle W. Anderson ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1309175110 ◽

2013 ◽

Vol 110 (36) ◽

pp. 14604-14609 ◽

Cited By ~ 67

Author(s):

Ying Zhang ◽

Don L. Rempel ◽

Jun Zhang ◽

Anuj K. Sharma ◽

Liviu M. Mirica ◽

...

Keyword(s):

Mass Spectrometry ◽

Amyloid Beta ◽

Conformational Changes ◽

Deuterium Exchange ◽

Peptide Aggregation ◽

Aβ Peptide ◽

Hydrogen Deuterium ◽

PAS Domain Allostery and Light-induced Conformational Changes in Photoactive Yellow Protein upon I2 Intermediate Formation, Probed with Enhanced Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of Molecular Biology ◽

10.1016/j.jmb.2006.07.078 ◽

2006 ◽

Vol 363 (1) ◽

pp. 148-160 ◽

Cited By ~ 33

Author(s):

Ronald Brudler ◽

Chris R. Gessner ◽

Sheng Li ◽

Sammy Tyndall ◽

Elizabeth D. Getzoff ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Intermediate Formation ◽

Deuterium Exchange ◽

Photoactive Yellow Protein ◽

Pas Domain ◽

Hydrogen Deuterium ◽

Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of Molecular Biology ◽

10.1016/j.jmb.2021.167334 ◽

2021 ◽

pp. 167334

Author(s):

Polina V. Zhdanova ◽

Alexander A. Ishchenko ◽

Alexander A. Chernonosov ◽

Dmitry O. Zharkov ◽

Vladimir V. Koval

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Dna Glycosylase ◽

Hydrogen Deuterium ◽

RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry

Physical Chemistry Chemical Physics ◽

10.1039/c0cp00817f ◽

2010 ◽

Vol 12 (41) ◽

pp. 13468 ◽

Cited By ~ 15

Author(s):

Victoria L. Morton ◽

William Burkitt ◽

Gavin O'Connor ◽

Nicola J. Stonehouse ◽

Peter G. Stockley ◽

...

Keyword(s):

Mass Spectrometry ◽

Coat Protein ◽

Conformational Changes ◽

Deuterium Exchange ◽

Viral Coat Protein ◽

Hydrogen Deuterium ◽

Viral Coat ◽

Using Hydrogen/Deuterium Exchange Mass Spectrometry to Study Conformational Changes in Granulocyte Colony Stimulating Factor upon PEGylation

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-011-0310-x ◽

2012 ◽

Vol 23 (3) ◽

pp. 498-504 ◽

Cited By ~ 48

Author(s):

Hui Wei ◽

Joomi Ahn ◽

Ying Qing Yu ◽

Adrienne Tymiak ◽

John R. Engen ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Stimulating Factor

Hydrogen‐deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XI a

Journal of Thrombosis and Haemostasis ◽

10.1111/jth.14632 ◽

2019 ◽

Vol 17 (12) ◽

pp. 2047-2055 ◽

Cited By ~ 1

Author(s):

Awital Bar Barroeta ◽

Josse Galen ◽

Ingrid Stroo ◽

J. Arnoud Marquart ◽

Alexander B. Meijer ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Factor Ix ◽

Factor Xi ◽

Hydrogen Deuterium ◽